Protein Alignment Msh6 and spel1

DIOPT Version :9

• Sequence 1: NP_648755.1
• Gene: Msh6 / 39654
• FlyBaseID: FBgn0036486
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_001014482.2
• Gene: spel1 / 34842
• FlyBaseID: FBgn0015546
• Length: 917
• Species: Drosophila melanogaster
• Alignment Length: 1120
• Identity: 249/1120 - (22%)
• Similarity: 416/1120 - (37%)
• Gaps: 355/1120 - (31%)

  Fly   188 QEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRP-------DHPD 245
            ||...|:.:||:::                         |:   |...|.|.:|       ||.
  Fly    10 QEPTLNMDTNARRN-------------------------FI---KFHAKLGEKPATTVRFFDHT- 45

  Fly   246 YDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGV-------NELG 303
             |:.|:|                   .||  ||.|..|:     :|...|.:|.       ..|.
  Fly    46 -DRYTVH-------------------GSD--DCELVAKI-----VYKSTAFIGALLPDDKKETLQ 83

  Fly   304 FTYM-RGEFAHSGFPEISFDKMSTILVDRGFKVA---------RVEQTETPDMMTERCKRIKATK 358
            |..| :|.|      |::   :..:|:.|.::|.         .:|...:|..:.:
  Fly    84 FVSMSKGNF------ELA---VRELLLVRNYRVEVYVKNSSDWEIEYRGSPGNLLQ--------- 130

  Fly   359 FDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGE 423
            |:.::      .:|:...|..|...:           :|:.|.|...|.||..::.:...|.|.|
  Fly   131 FEDIL------FSNKEVLVGNSIISL-----------LVKLDGGGQRRVGVASVEQNDCKFQLLE 178

  Fly   424 FEDD---------------KNC---------SRLLTLVSHHMPVLFLNEKSA---LSQRTQQIVR 461
            |.||               |.|         |.:.||:..:..::.:.:||.   |.|...:::|
  Fly   179 FLDDDFFTELEATVVLLGPKECLLPSIEGEYSAVKTLLDRNGVMITMPKKSGDNDLLQDLNRLLR 243

  Fly   462 TVLGGILKEPVPG----NGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPN 522
            ...|  .:|...|    ..:.|.:|.||    |.:|.              .:.:|..:||
  Fly   244 FAKG--QQEDATGLKELQLQLASNALKT----AIKYL--------------DLVNDAGNLG---- 284

  Fly   523 DNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLS 587
             :|::....|.:   |:|                                        ||:..::
  Fly   285 -HYEIKQLDLNR---FVH----------------------------------------LDSAAVA 305

  Fly   588 NLRIIGEE-----------HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRM 641
            .|.|:.:.           .|:|..||||.|..|.||:..|:..|....:::.:|.:.:..|:..
  Fly   306 ALNIMPKPGTHPSMPSYRWQSVLGVLDHCRTPQGHRLMGQWVKQPLRSRNILNDRHNIVQCLLES 370

  Fly   642 PTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGF 706
            |..::.:..      |:.:.:..|.:...|.:::                 |..||....:.:..
  Fly   371 PDTMETLSL------DYLKRIPDILMLTKKLMRR-----------------KANLQDLFRIYQVI 412

  Fly   707 NDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKEL----QYFATAFDHDAAAKTGVIAPQAG 767
            ....|:..:.|:...:.::.:...|     |....|:|    |......|.:|..:...:
  Fly   413 LRTPKILKVLHELDNSTIESVICAP-----FKSFLKDLTGLKQMVEQVVDFEAIERGEYL----- 467

  Fly   768 MDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYFGSDKKRYQLDVPESHASKANKSYTLEGQ 832
            :.|.:|:.:..:.::...|  |...:|..|.|                        ::...|:|:
  Fly   468 VKASFDSRLMELQQMMTEL--YSKMEELQFKC------------------------SQELNLDGK 506

  Fly   833 TKGKKPSRRYTTAETRALLKDMQHAEDTRNM----VLKDLARRLFEKFSNHYDQWKQC------- 886
            .:.|..|........|..:||.......:|.    |:|...|...:|...:.|::..|
  Fly   507 NQVKLESVAKLGHHFRITVKDDSVLRKNKNYRIVDVIKGGVRFTSDKLEGYADEFASCRTRYEEQ 571

  Fly   887 ------------IDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQ---LEEG-------- 928
                        :...|.|.:|.:  |.|....::........|..|:::   ||||
  Fly   572 QLSIVEEIIHVAVGYAAPLTLLNN--ELAQLDCLVSFAIAARSAPTPYVRPKMLEEGARELVLED 634

  Fly   929 -YHPCANAS---TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASC 989
             .|||....   .:|.|.::. ...|..:.::||||||||||.:|.||..|:||.|||.:|.:..
  Fly   635 VRHPCLELQEHVNFIANSVDF-KKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLA 698

  Fly   990 RLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAAS 1054
            .:|:||.|..|:||.|:|:.|.|||:||:.|||.|::.||..|||::|||||||:||:|..||.|
  Fly   699 TISMVDSILGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWS 763

  Fly  1055 VVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGAC 1118
            :...|| ..||.|||:||:|.:.........:...|||.:.:.:|        .|.||:..:|..
  Fly   764 IAEHLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADADD--------FTLLYQVRSGVM 820

  Fly  1119 PKSYGFNAAKLAGMPQGIIKRAYEL----------SKKVEAIALQRKITAKI-VAATAGNE-DTK 1171
            .||:|...|:||..|:.:::.|.|:          .:|.|..||..||...| ..:||||. |..
  Fly   821 EKSFGIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKIQVAIQQLSTAGNNVDIN 885

  Fly  1172 KEKINAL-----KDL 1181
            .|.:..|     ||:
  Fly   886 VEDLTQLVTQFTKDI 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	234/1040 (23%)
		MutS_I	263..375	CDD:279898	22/128 (17%)
		MutS_II	391..508	CDD:282973	31/147 (21%)
		MutS_III	584..>667	CDD:282977	19/93 (20%)
		MutS_IV	767..859	CDD:282975	14/91 (15%)
		ABC_MSH6_euk	924..1140	CDD:213253	92/231 (40%)
spel1	NP_001014482.2	MutS_I	24..132	CDD:279898	30/156 (19%)
		MutS_II	149..287	CDD:282973	34/173 (20%)
		MUTSd	324..643	CDD:214710	65/379 (17%)
		MutS_III	326..>414	CDD:282977	21/110 (19%)
		MutS_IV	471..567	CDD:282975	20/121 (17%)
		MutS_V	617..852	CDD:278891	94/243 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11361
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850