DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and MSH6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_024308587.1	Gene:	MSH6 / 2956	HGNCID:	7329	Length:	1391	Species:	Homo sapiens

Alignment Length:	1308	Identity:	531/1308 - (40%)
Similarity:	760/1308 - (58%)	Gaps:	173/1308 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GTPTNTLLNYFSKSPA---FDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRK 72
            |......:.:|..||.   ..|:.|.|..     .|||::..        |.|...::||...|.
Human   124 GKSVRVHVQFFDDSPTRGWVSKRLLKPYT-----GSKSKEAQ--------KGGHFYSAKPEILRA 175

  Fly    73 LPISDDEPASGQRKRKRIVQPESDSEP----EMEV------TKSEDD------------------ 109
            :..:|:.....:.||..:...:..|||    ||||      .|||:|
Human   176 MQRADEALNKDKIKRLELAVCDEPSEPEEEEEMEVGTTYVTDKSEEDNEIESEEEVQPKTQGSRR 240

  Fly   110 ----------FSDCASD-------YEPD-ENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKK 156
                      .||..||       ::|| :.|.|.|.:|||   |..||:: .::||. |.:||:
Human   241 SSRQIKKRRVISDSESDIGGSDVEFKPDTKEEGSSDEISSG---VGDSESE-GLNSPV-KVARKR 300

  Fly   157 SKILNNNNNNEPSSKKVKLESTIQLAEGATFQEK--------LKNLQSNAKQDASYDDIVTNTSN 213
            .:::..|.:.:..|.:.:..|..:.|...:.:.|        .:|.:|.|......||
Human   301 KRMVTGNGSLKRKSSRKETPSATKQATSISSETKNTLRAFSAPQNSESQAHVSGGGDD------- 358

  Fly   214 LDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDC 278
            ...|.||.|:.||:|:.:|.:|:..|||||||:|.|||:|||.|||..:||:|:||.:||.|:|.
Human   359 SSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDL 423

  Fly   279 VLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTET 343
            |:.:|||||||||||||.:||:|||..:|:|.:||||||||:|.:.|..||.:|:||||||||||
Human   424 VICYKVGKFYELYHMDALIGVSELGLVFMKGNWAHSGFPEIAFGRYSDSLVQKGYKVARVEQTET 488

  Fly   344 PDMMTERCKRI-KATKFDKVVAREICQITNRGTQVFGSQCKIGPN-HQPNYMLAIVEKDE---GT 403
            |:||..||::: ..:|:|:||.||||:|..:|||.: |..:..|: :...|:|::.||:|   |.
Human   489 PEMMEARCRKMAHISKYDRVVRREICRIITKGTQTY-SVLEGDPSENYSKYLLSLKEKEEDSSGH 552

  Fly   404 CSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGIL 468
            ...|||||:|||:|.|.:|:|.||::|||..|||:|:.||..|.||..||:.|:.|:::.|...|
Human   553 TRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTILKSSLSCSL 617

  Fly   469 KEP-VPGNGKHACSAEKTLK-LLAERYYAGPGSDD---NWPLVLRTMQSDMDHLGLTPNDNYKLA 528
            :|. :||:  ....|.|||: ||.|.|:....||.   ..|.||:.|.|:.|.:||||.:..:||
Human   618 QEGLIPGS--QFWDASKTLRTLLEEEYFREKLSDGIGVMLPQVLKGMTSESDSIGLTPGEKSELA 680

  Fly   529 LKALGQCIFFIHKCKLEPKVLPMARYQLYVP--PDQLADAKPAVASTLRRSHMVLDATTLSNLRI 591
            |.|||.|:|::.||.::.::|.||.::.|:|  .|.::..:.....|.....|||||.||:||.|
Human   681 LSALGGCVFYLKKCLIDQELLSMANFEEYIPLDSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEI 745

  Fly   592 I------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRA 650
            .      ..|.:||..:|.|.|.||||||..|||||.|:...|.:|.|||.:|:.:|.::.||..
Human   746 FLNGTNGSTEGTLLERVDTCHTPFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVE 810

  Fly   651 LLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTM 715
            ||..:||.||.|::||..|: .:|..:|||||||::||..|:|:|:..|::.|:||..:.|:..:
Human   811 LLKKLPDLERLLSKIHNVGS-PLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGI 874

  Fly   716 FHQC----KTTLLKRI----TQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEY 772
            ..:.    |:.:||::    |:.||  |.||||:.||..:.|||||:.|.|||:|.|:||.|::|
Human   875 MEEVADGFKSKILKQVISLQTKNPE--GRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDY 937

  Fly   773 DAAMDSIGEVEKRLKTYLVEQERHFGCR-ITYFGSDKKRYQLDVPESHASK-ANKSYTLEGQTKG 835
            |.|:..|.|.|:.|..||.:|....||| |.|:|..:.||||::||:..:: ..:.|.|:...||
Human   938 DQALADIRENEQSLLEYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKG 1002

  Fly   836 KKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLA 900
            .|   ||.|......|.::.:||:.|::.|||..||||..|..:|..|:..::|:|.||||..||
Human  1003 CK---RYWTKTIEKKLANLINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLA 1064

  Fly   901 EYA-GQQMVICVPELVSDAD-QPFIQLEEGYHPCAN----ASTYIPNGLELGTASE------APL 953
            .|: |....:|.|.::...| .||::|:...|||..    ...:|||.:.:|...|      |..
Human  1065 NYSRGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEEEQENGKAYC 1129

  Fly   954 SLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVEL 1018
            .|:|||||||||||||:.|||.:|||:|.::||..|||:.:||:||||||.|.|::|.|||.|||
Human  1130 VLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIMSGESTFFVEL 1194

  Fly  1019 NETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLA-NLKCRTLFSTHYHNLIDFFHND 1082
            :||:.||.|||.|||||:|||||||||:||||||.:||..|| .:|||||||||||:|::.:..:
Human  1195 SETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSQN 1259

  Fly  1083 KRITLGHM-------------------------------ACMVENEDNADPTQETVTFLYKYTAG 1116
            ..:.||||                               |||||||.. ||:|||:|||||:..|
Human  1260 VAVRLGHMVCANCFFPQIRFFERALLLLAHVSLIFFFLKACMVENECE-DPSQETITFLYKFIKG 1323

  Fly  1117 ACPKSYGFNAAKLAGMPQGII----KRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINA 1177
            |||||||||||:||.:|:.:|    ::|.|..|..:::.|.|::   .:|:.....|.  |.::.
Human  1324 ACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLFREV---CLASERSTVDA--EAVHK 1383

  Fly  1178 LKDLLKQL 1185
            |..|:|:|
Human  1384 LLTLIKEL 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	40/157 (25%)
		MutS	261..1186	CDD:223327	446/1001 (45%)
		MutS_I	263..375	CDD:279898	67/112 (60%)
		MutS_II	391..508	CDD:282973	53/124 (43%)
		MutS_III	584..>667	CDD:282977	40/88 (45%)
		MutS_IV	767..859	CDD:282975	34/93 (37%)
		ABC_MSH6_euk	924..1140	CDD:213253	133/261 (51%)
MSH6	XP_024308587.1	MSH6_like	88..195	CDD:99898	18/83 (22%)
MSH6	XP_024308587.1	MutS	407..1367	CDD:223327	439/969 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158978
Domainoid	1	1.000	257	1.000	Domainoid score	I2035
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	879	1.000	Inparanoid score	I409
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto91134
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770