DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh5

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_997701.2	Gene:	Msh5 / 294252	RGDID:	1303008	Length:	830	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	208/875 - (23%)
Similarity:	352/875 - (40%)	Gaps:	223/875 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGIL---- 468
            |:.:.|||....|......|....:||..|...     :|.:|.::...|....|...|.|
  Rat    59 GIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDE-----INPQSVVTSAKQDEAMTQFLGKLASQE 118

  Fly   469 -KEP-------VPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLT---PN 522
             :||       :|       |.:...::..:|..:|     |:..:..:|.:....|.|:   |.
  Rat   119 HREPKRPEIILLP-------SVDFGPEISKQRLLSG-----NYSFISESMTATEKILFLSSIIPF 171

  Fly   523 DNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMV-LDATTL 586
            | ..|.::|||..:.|:.:.::.   :.:..|.:.||   :...|..|.     :|:| :|..|.
  Rat   172 D-CVLTVRALGGLLKFLSRRRVG---VELEDYSVGVP---ILGFKKFVL-----THLVSIDQDTY 224

  Fly   587 SNLRII-GEEH--------------SLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIG 636
            |.|:|. .|.|              ||...|:.|..::|::||..|...|:.::..:..|.|.|
  Rat   225 SVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCRWGQKLLRLWFTRPTRELRELNSRLDVI- 288

  Fly   637 ELIRMPTEL---QEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQG 698
            |...||..|   |.:..||:.:    :|:..|       :|:|.       |...|:.:.|.|..
  Rat   289 EFFLMPQNLDMAQMMHRLLSHI----KNVPLI-------LKRMK-------LSHTKVSDWQVLYK 335

  Fly   699 FMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKE----LQYFATA-----FDHD 754
            .:....|..|         .|::        ||:|...|.|:::|    |.:.|:.     |:..
  Rat   336 TVYSALGLRD---------ACRS--------LPQSIQLFRDITQEFSDDLHHIASLIGKVDFEES 383

  Fly   755 AAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR----LKTYLVEQERHF---------GCRITY--- 803
            .|.....:.|  .:|.|.||        :||    |.::|.|..:..         .|.:.|
  Rat   384 LAENRFTVLP--NIDPEIDA--------KKRRLMGLPSFLTEVAQKELENLDSCIPSCSVIYIPL 438

  Fly   804 FGSDKKRYQLDVPESHASKANKSYTLEG-----QTKGKKPSRRYTTAETRALLKDMQHAEDTRNM 863
            .|     :.|.:|..........:.:||     .::.|...|...|.|..|||.|: |.|
  Rat   439 IG-----FLLSIPRLSFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDALLGDL-HCE----- 492

  Fly   864 VLKDLARRLFEKFSNHYDQWKQC------------IDCVANLDVLGSLAE------YAGQQMVIC 910
             ::|....|..:.        ||            :|..:.||||.:||.      |:......|
  Rat   493 -IRDQEMLLMHQL--------QCQVLARAPVLTRVLDLASRLDVLLALASAARDYGYSRPHYSPC 548

  Fly   911 VPELVSDADQPFIQLEEGYHP----CANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREV 971
            :..         ::::.|.||    ||.  |::||..:.| ..:..:.::||||..|||..:::|
  Rat   549 IQG---------VRIKNGRHPLMELCAR--TFVPNSTDCG-GDQGRVKVITGPNSSGKSIYLKQV 601

  Fly   972 GLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLL 1036
            ||:..||.:|:.:||....:.::|.||||:.:.:.|..|.|||:::||:.:..:.:||.|||||:
  Rat   602 GLITFMALVGSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLI 666

  Fly  1037 DELGRGTATYDGTAIAASVVNFLANL--KCRTLF-STHYHNLIDFFHNDKRITLGHMA---CMVE 1095
            ||.|:||.:.||.|:..:|:.....|  .|..:| :|::.:|:..    :.:..|.:.   .|..
  Rat   667 DEFGKGTNSVDGLALLTAVLRHWLALGPSCPHIFVATNFLSLVQL----QLLPQGPLVQYLTMET 727

  Fly  1096 NEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEA---IALQRKIT 1157
            .||..|     :.|.|:...|....|:....|..||:|..:|.|..|:|..:.:   :....::.
  Rat   728 CEDGND-----LVFFYQLCHGVASASHASYTAAQAGLPDPLIARGKEVSDSIRSGKPVKPMHELV 787

  Fly  1158 AKIVAATAGNEDTKKEKINALKDLLKQLKM 1187
            .:          |:.|...||.|  |.||:
  Rat   788 RR----------TQMENCQALVD--KFLKL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	206/872 (24%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	22/111 (20%)
		MutS_III	584..>667	CDD:282977	27/100 (27%)
		MutS_IV	767..859	CDD:282975	25/112 (22%)
		ABC_MSH6_euk	924..1140	CDD:213253	71/225 (32%)
Msh5	NP_997701.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		DUF3160	<63..>147	CDD:288259	19/95 (20%)
		MUTSd	250..565	CDD:214710	83/389 (21%)
		MutS_III	250..379	CDD:282977	38/164 (23%)
		MutS_III	394..492	CDD:302670	25/111 (23%)
		MutS_III	<471..532	CDD:282977	19/75 (25%)
		ABC_MSH5_euk	553..759	CDD:213248	68/217 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820