DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and msh6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_878280.1	Gene:	msh6 / 260437	ZFINID:	ZDB-GENE-020905-3	Length:	1369	Species:	Danio rerio

Alignment Length:	1243	Identity:	527/1243 - (42%)
Similarity:	745/1243 - (59%)	Gaps:	110/1243 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YFSKSPAFDK--------------KKLTPSVKTDP-DASKSEKENLQNQQPKVKDGK------KE 63
            :||..|...|              ::|...:..|| |..:.::|:::.::..|.|.:      ||
Zfish   160 FFSGKPVIRKAMELADVAMKDSPEQRLKMPLCMDPSDEEEEDEEDMEIEKSTVSDAEMSEEEVKE 224

  Fly    64 ASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDS 128
            .:||:  |:.|.:..|.:...::|:.:|..:||.        |.::|....:....||::..::.
Zfish   225 KTKPS--RRPPRAAAEKSQKSKRRRIVVASDSDD--------SGEEFDPNKAGGSSDEDKEEEEG 279

  Fly   129 VSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKLKN 193
            |:||||| ..||.:...|||.....||:.       ..:|:..|.|.| |.:.|..|     |.:
Zfish   280 VNSGAEE-EESEPETEPDSPVKPIKRKRP-------TEKPTKSKSKPE-TPKRAPAA-----LPS 330

  Fly   194 LQSNAKQDAS-------YDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTL 251
            :.::||...|       :|...:.........||.|:|||:||..|.||.:.:|....:||.:||
Zfish   331 VSTDAKSRLSAFSAPDNFDSQSSANGTEGGSTVWDHEKLEWLQDGKRKDAQRKRQSDENYDPTTL 395

  Fly   252 HVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGF 316
            :|||.|||..:||:|:||.|||:.:|.|||:|||||||||||||.:|||||..|:|:|.:|||||
Zfish   396 YVPEDFLNRTTPGMRRWWQLKSEMFDTVLFYKVGKFYELYHMDAVIGVNELNLTFMKGTWAHSGF 460

  Fly   317 PEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRI-KATKFDKVVAREICQITNRGTQVFGS 380
            |||.|.:.|.:||.:|:|||||||||||:||..|||:: :.|||||||.||:|:|..||||.:..
Zfish   461 PEIGFGRFSDVLVQKGYKVARVEQTETPNMMEARCKKLARPTKFDKVVKREVCRIITRGTQTYSV 525

  Fly   381 QCKIGPNHQPNYMLAIVEKDE----GTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHM 441
            ........|..|:|:|.||.|    |....|||||||||:|.||:|:|:||::||||.|||:|:.
Zfish   526 LDGAPSETQSKYLLSIKEKSEEDSTGHGHIYGVCFIDTSVGRFHIGQFQDDRHCSRLRTLVAHYS 590

  Fly   442 PVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDN---- 502
            |...:.||...|..|.:|.:.::...|:|.: ..|.....|:||||:|||..|.....|||
Zfish   591 PAQVIFEKGNPSIETLKIFKAIVASSLQEGL-NAGSQFWDAQKTLKVLAEEDYFKESKDDNKKAS 654

  Fly   503 -WPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPD----Q 562
             .|..|:.|..:.|.|.|||...|:|||.|||.|:|::.||.::.::..|..::.|||.|    |
Zfish   655 VLPPALKAMTPECDALSLTPKTGYELALSALGGCMFYLKKCLVDQELFSMGNFEEYVPVDVEMEQ 719

  Fly   563 LADAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAP 621
            ...|....|.|.:|  ||||..||:||.|:      |.|.:||..||.|||.||||||..|:|||
Zfish   720 AGGASCFFAKTNQR--MVLDGVTLANLEILQNSSTGGPEGTLLERLDTCCTPFGKRLLKQWICAP 782

  Fly   622 SCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILF 686
            .|::|.|.:|.||:.:|:..|::..||..||..:||.||.|::||..|. .:|..|||||||||:
Zfish   783 LCNLSSIGDRLDALEDLMGAPSQTSEVTDLLKKLPDLERLLSKIHSMGT-PLKGQDHPDSRAILY 846

  Fly   687 EEKLYNKQKLQGFMAVLKGFNDLTKLPTMF----HQCKTTLLKRITQL--PESGGSFPDLSKELQ 745
            ||.:|:|:|:..|:|.|:||..:.::.::.    ...|:.||:::..|  ....|.|||||.||:
Zfish   847 EEVVYSKRKIADFLAALEGFKVMKEIVSIMEPVGEDLKSKLLRQVVLLKTENEDGLFPDLSPELK 911

  Fly   746 YFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCR-ITYFGSDKK 809
            .:.|||||..|..||||.|:||.|.|||.|::.|.|.|:.|:.||..|::..||: ::|:|:.:.
Zfish   912 RWDTAFDHQKARTTGVITPKAGFDPEYDQALNGIKECERDLQDYLDRQKKRLGCKNLSYWGTGRN 976

  Fly   810 RYQLDVPESHASKA-NKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLF 873
            ||||:||||.:.:: .:.|.:....||.|   ||:|.:...:..::|..||.|:..|||..||||
Zfish   977 RYQLEVPESVSERSLPEEYEVRSTKKGWK---RYSTKDIERMFSELQSWEDKRDAALKDCMRRLF 1038

  Fly   874 EKFSNHYDQWKQCIDCVANLDVLGSLAEYA-GQQMVICVPELVSDAD----QPFIQLEEGYHPCA 933
            ..|..:|..|:..::|:|.||||.|:..|: .....:..||:....|    .||:.|....|||.
Zfish  1039 YNFDKNYKDWQTAVECMAVLDVLLSMCRYSQSADGSMARPEMALPGDGSYSAPFLDLRGSRHPCV 1103

  Fly   934 N----ASTYIPNGLELG-----------TASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAH 983
            .    ...:|||.:.:|           |.:.||..|:|||||||||||||:.||:||:||:|.:
Zfish  1104 TKTFFGDDFIPNDIFIGCPGDEEEAQDDTKALAPCVLVTGPNMGGKSTLMRQCGLVVILAQLGCY 1168

  Fly   984 IPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDG 1048
            :||.|.||:.|||:||||||.|.|::|.|||.|||:||:.||.|||.||||||||||||||||||
Zfish  1169 VPAESLRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILLHATNHSLVLLDELGRGTATYDG 1233

  Fly  1049 TAIAASVVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYK 1112
            ||||::||..|: .:.||||||||||:|::....|..:.|||||||||||.. ||:|||:|||||
Zfish  1234 TAIASAVVKELSEKICCRTLFSTHYHSLVEDHVQDPAVRLGHMACMVENECE-DPSQETITFLYK 1297

  Fly  1113 YTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINA 1177
            :..||||||||||||:||.:|:.:|:..::.::..|...:..:|..|: .:.|.:...::|::..
Zfish  1298 FIRGACPKSYGFNAARLANIPEDVIQSGHKKARDFERSTVSLRIFKKL-CSFAESPRAEREQLTT 1361

  Fly  1178 LKDLLKQL 1185
            |...|:.|
Zfish  1362 LIQTLRNL 1369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	30/117 (26%)
		MutS	261..1186	CDD:223327	454/974 (47%)
		MutS_I	263..375	CDD:279898	74/112 (66%)
		MutS_II	391..508	CDD:282973	53/125 (42%)
		MutS_III	584..>667	CDD:282977	42/88 (48%)
		MutS_IV	767..859	CDD:282975	33/93 (35%)
		ABC_MSH6_euk	924..1140	CDD:213253	136/231 (59%)
msh6	NP_878280.1	PWWP	83..188	CDD:295359	5/27 (19%)
		MutS	406..1335	CDD:223327	447/936 (48%)
		MutS_I	406..524	CDD:279898	77/117 (66%)
		MutS_II	537..693	CDD:282973	69/156 (44%)
		MutS_III	740..>828	CDD:282977	42/87 (48%)
		MutS_IV	933..1025	CDD:282975	34/94 (36%)
		P-loop_NTPase	1095..1322	CDD:304359	135/227 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594953
Domainoid	1	1.000	257	1.000	Domainoid score	I1989
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	895	1.000	Inparanoid score	I370
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto40457
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910