DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and msh1

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_593649.2	Gene:	msh1 / 2542833	PomBaseID:	SPAC13F5.01c	Length:	941	Species:	Schizosaccharomyces pombe

Alignment Length:	998	Identity:	245/998 - (24%)
Similarity:	402/998 - (40%)	Gaps:	277/998 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 DCVLFFKVGKFYELYHMDAD-----VGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFK-V 335
            ||||..|||.|||:|...|:     :.:........:.:.:.:|||....|:...|||:...| |
pombe    76 DCVLLTKVGNFYEMYFEQAEKIGPLLNLRVSKKKTSKSDVSMAGFPFFKLDRYLKILVEDLKKCV 140

  Fly   336 ARVEQTETP-DMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIV-- 397
            |..|:...| |.::.:          .:..|.:.::...||.:  .:..:.| ::.||:|.:|
pombe   141 ALSEEVIRPVDDLSSK----------NMYIRSVTRVITPGTLI--DENFMNP-YESNYILTVVFD 192

  Fly   398 ---------------EKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRL---LTLVSHHMPVL 444
                           :||.....:.|:.::|.|.|:|    |..|.|..||   ||.:|....||
pombe   193 PNFFSSDISNQGTAEDKDCFADCKIGLSWLDLSTGEF----FTQDSNLQRLAGDLTRISPREIVL 253

  Fly   445 FLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRT 509
               ::|..|..|..|.     ..::|           .:..|..:..||.    |.|.|.   :.
pombe   254 ---DESLKSFTTHPIY-----SFIQE-----------RKYFLSYVENRYQ----SLDCWN---KF 292

  Fly   510 MQSDMDHLGLTPNDNYKLALKALGQCIFFIHKC-KLEPKVLPMARYQLYVPPDQLADAKPAVAST 573
            ::.::|     |:               ||..| |||  |........|: .|:|.::.|.:...
pombe   293 LEKEID-----PS---------------FIKYCTKLE--VTAGCTLISYI-ADRLQNSHPNIQPP 334

  Fly   574 LRRS---HMVLDATTLSNLRIIGEEH------SLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIK 629
            :|.|   :|::..:.:..|.|....:      |||..::...||.|.|||...|||||.::..|.
pombe   335 IRVSLNEYMIIGESAMKGLEIRSSLYQNRYTGSLLHAINKTVTKSGSRLLTRRLCAPSTNIVEIN 399

  Fly   630 ERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLF---GNKQIKQMDHPDSRAILFEEKLY 691
            .|.|.:.:...:|....:|..||....|..|.|.  ||.   ||..
pombe   400 NRLDLVEKFKLLPELCSKVINLLKKSNDTHRILQ--HLLMGRGNSY------------------- 443

  Fly   692 NKQKLQGFMAVLKGFNDLTKLPTMFHQCKTTLLKRITQL--P-ESGGSFPDLSKEL-------QY 746
                            ||.|:...|     ::.|.|..|  | ||..:|..|...:       |.
pombe   444 ----------------DLLKMADNF-----SITKEIHSLLSPLESSSAFRLLLLNMHPHDELKQL 487

  Fly   747 FATAFDHDAAAK--------TGVIAPQA----------------GMDAEYDAAM----------- 776
            ...|.|.:|..|        |.|||.:|                .:.:|:|...
pombe   488 INNAVDENALMKQKINEEEETEVIAQEAEEILQDENAQVEIVKKSLSSEFDIRQSFKENWVVKSN 552

  Fly   777 --DSIGEVEKRLKTYLVEQE-------RHFGCRITYFGSDKKRYQLDVPES-------------- 818
              :::.::.::|::.....:       :..|.:.|...|..|.|.:.:..|
pombe   553 FNNNLRKLHEKLQSLFASYDKLQEDLSKRLGKKATLRKSPAKLYYVHLKLSGNETIERFIKKFTQ 617

  Fly   819 ----HASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQ------HAEDTRNMVLKDLARRLF 873
                .::|:..|:.|.|.|               :|..|::      |.|:.|  |||.:.
pombe   618 AVLFQSTKSTASFQLPGWT---------------SLGMDLENTKLHIHQEEQR--VLKSIT---- 661

  Fly   874 EKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQ------LEEGYHPC 932
            ::..:|:...:...:.:..||:..|||..|.:|          |..:|.:.      :.:|.||.
pombe   662 DEIVSHHKTLRSLANALDELDISTSLATLAQEQ----------DFVRPVVDDSHAHTVIQGRHPI 716

  Fly   933 ANAS------TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRL 991
            ....      .:.||...:|..: ..:.|:|||||.||||.:|:..::.|:||||:.:||::.|:
pombe   717 VEKGLSHKLIPFTPNDCFVGNGN-VNIWLITGPNMAGKSTFLRQNAIISILAQIGSFVPASNARI 780

  Fly   992 SLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVV 1056
            .:||:||:|:|:.|::....|||:||:.|||.|||:||..|.|::||:||||...||.|||...:
pombe   781 GIVDQIFSRIGSADNLYQQKSTFMVEMMETSFILKNATRRSFVIMDEIGRGTTASDGIAIAYGCL 845

  Fly  1057 NFLANLK-CRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPK 1120
            .:|:.:. .||||:||.|.|.:...:.|.:     .|...|. :.|....|.:|.||...|...:
pombe   846 KYLSTINHSRTLFATHAHQLTNLTKSFKNV-----ECYCTNL-SIDRDDHTFSFDYKLKKGVNYQ 904

  Fly  1121 SYGFNAAKLAGMPQGIIKRAYEL 1143
            |:|...|::||:|:.::..|.|:
pombe   905 SHGLKVAEMAGIPKNVLLAAEEV 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	245/998 (25%)
		MutS_I	263..375	CDD:279898	26/104 (25%)
		MutS_II	391..508	CDD:282973	32/136 (24%)
		MutS_III	584..>667	CDD:282977	26/88 (30%)
		MutS_IV	767..859	CDD:282975	17/135 (13%)
		ABC_MSH6_euk	924..1140	CDD:213253	82/228 (36%)
msh1	NP_593649.2	MutS	55..941	CDD:223327	245/998 (25%)
		MutS_I	72..176	CDD:279898	28/111 (25%)
		MutS_II	217..332	CDD:282973	39/167 (23%)
		MutS_III	348..>459	CDD:282977	35/152 (23%)
		MutS_III	552..648	CDD:302670	14/110 (13%)
		MutS_V	696..934	CDD:278891	85/239 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710