DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and msh6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_588344.1	Gene:	msh6 / 2539215	PomBaseID:	SPCC285.16c	Length:	1254	Species:	Schizosaccharomyces pombe

Alignment Length:	1274	Identity:	377/1274 - (29%)
Similarity:	596/1274 - (46%)	Gaps:	234/1274 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDA-----SKSEKENLQNQQPKVKDG 60
            :|..|:.|....|.::|   ..:||.   |.|..|||.:||:     |.::|::.::....:...
pombe   108 LSSSLHRSSPKRPHDSL---GEESPG---KLLRTSVKQEPDSEEEIDSPTKKKSFKSLDTSIFQA 166

  Fly    61 KKEASKPAAKRKLPISD----DEP-ASGQRKRKRIVQPESDSEPEME--VTKS-------EDDFS 111
            :.:...|.:. ||..|:    |:| .:.:|.||.:...|||.:.:.:  .||.       .||.|
pombe   167 EDQFRHPVSS-KLENSELSEVDKPFIASRRSRKPVSYAESDEDEDFDDAPTKGSRHKRIVSDDES 230

  Fly   112 DCASDY-EPDE-NEASD------DSVSSGAEEVSP-SENDMSVDSPTPKKSRKKSKILNNNNNNE 167
            |   || |||. :|||.      |.|.|..|:|.. |::.:||.:|.|||..:|
pombe   231 D---DYVEPDHISEASSEASLPIDEVESMDEDVDGYSDHSVSVAAPIPKKESRK----------- 281

  Fly   168 PSSKKVKLESTIQLAE----GATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFL 228
                    ||:..|.|    |:.......::..:|....|..:.|.|....      ..|::|..
pombe   282 --------ESSNSLYESYRLGSQIASPSPSVSGSASPTKSNKNGVLNREEK------RRQRMEAF 332

  Fly   229 QPDK---------IKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKV 284
            :.:.         ::|.:..|...|:||..||::|........|..:|:|.:|.|..|.|:||:.
pombe   333 KKENNERYEWLLDVRDADQNRVGDPNYDPRTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQK 397

  Fly   285 GKFYELYHMDADVG--VNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMM 347
            |||||||..||.:|  |..|..| .|......|.||.|||..::..:.:|:::|||:|.||. :.
pombe   398 GKFYELYENDAAIGHQVFSLKLT-DRVNMKMVGIPEASFDYWASQFIAKGYRIARVDQLETA-LG 460

  Fly   348 TERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVE--KDEGTCSRYGVC 410
            .|...|.:..|.:|||.|.:.|:...||.|..:..   .:....|.:||.|  :.:.....:|:|
pombe   461 KEIKDRQRTQKEEKVVQRGLTQVLTSGTLVDEAML---TSDLSTYCMAIKESLQSDNEEPSFGIC 522

  Fly   411 FIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGN 475
            |||||.|.||:.||.||.:.::|.||::...|...:.|||.:||::.:.::
pombe   523 FIDTSTGGFHMCEFTDDIHRTKLDTLLTQVRPKELILEKSKISQKSIRAIK-------------- 573

  Fly   476 GKHACSAEKTL------------------KLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPN 522
               .|.:..::                  :::|..|:  ....:..|.:|::..|:.
pombe   574 ---YCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYF--KNGLEGAPKILKSYLSEK-------- 625

  Fly   523 DNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMVLDATTLS 587
               .||:.|.|...:::.:.||:..:..|..:..|       ||.....|      ::::..||.
pombe   626 ---PLAISAFGALFWYLRQLKLDKDMCSMGNFDEY-------DASQQSTS------LLMNGQTLK 674

  Fly   588 NLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQ 646
            ||.|.      |.|.:|...|..|.|.|||||.|.|||.|....:.|..|.|.:..:...|....
pombe   675 NLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLDVVELIADNPVIRD 739

  Fly   647 EVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTK 711
            .:...|..:||.||.::::|.                        .:.|...|:.||:||.   :
pombe   740 TIWGFLHKLPDLERLISRVHA------------------------GRSKPADFVRVLEGFQ---R 777

  Fly   712 LPTMFHQCKT--------TLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGM 768
            :.:.|.|.:.        |||..|.|      |.|::.:||:.:..||:...|::.||..|:.|.
pombe   778 INSAFDQLREEFMEVAEGTLLGEIIQ------SAPNMKEELEAWTRAFNWQKASEEGVFEPEIGF 836

  Fly   769 DAEYDAAMDSIGEVEKRLKTYLVEQERHFGC-RITYFGSDKKRYQLDVPESHASKANKSYTLEGQ 832
            :||||.:.....|::..|...|.:.::...| .:.:....|:.||::||.......|..     :
pombe   837 EAEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSDVKVPVNWC-----K 896

  Fly   833 TKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLG 897
            ..|.|.:.||...|.|..:|.:..||:....::..:..:.:.:|.::|:||...|...|::|...
pombe   897 MSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFF 961

  Fly   898 SLAEYA---GQQMVICVPELVSDADQPFIQLEEGYHPCAN---ASTYIPNGLELGTASEAP-LSL 955
            ||::.|   |:.  .|.||::...| ..:..||..|||.|   |||::||.:.||  .|:| :.:
pombe   962 SLSQAAAALGEP--YCRPEIIEQKD-GHLYFEELRHPCINASAASTFVPNDVVLG--GESPNMIV 1021

  Fly   956 LTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNE 1020
            ||||||.|||||:|:|.:.|||||:|..:||....::.:..|:|||||.|||::..|||:|||:|
pombe  1022 LTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSE 1086

  Fly  1021 TSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFL-ANLKCRTLFSTHYHNL-IDFFHNDK 1083
            |..||......|||:||||||||:||||.|||.:|::.| :|:.|...|||||.:| :||.|: :
pombe  1087 TKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHH-R 1150

  Fly  1084 RITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVE 1148
            ::.|..||..|      |.....||||||...|.||||||.|.|.:||:|:.:|..|.|.:.::|
pombe  1151 QVRLMQMAAAV------DEKIRRVTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELE 1209

  Fly  1149 AIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLKM 1187
                  :.:|..:.|:        :.|..:.|.|:.|::
pombe  1210 ------QASASFINAS--------DDIALMSDFLQVLRI 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	39/134 (29%)
		MutS	261..1186	CDD:223327	302/970 (31%)
		MutS_I	263..375	CDD:279898	44/113 (39%)
		MutS_II	391..508	CDD:282973	31/136 (23%)
		MutS_III	584..>667	CDD:282977	30/88 (34%)
		MutS_IV	767..859	CDD:282975	23/92 (25%)
		ABC_MSH6_euk	924..1140	CDD:213253	110/221 (50%)
msh6	NP_588344.1	MutS	369..1254	CDD:223327	303/978 (31%)
		MutS_I	376..493	CDD:279898	47/118 (40%)
		MutS_II	502..645	CDD:282973	38/172 (22%)
		MutS_III	671..794	CDD:282977	39/149 (26%)
		MutS_IV	835..924	CDD:282975	24/93 (26%)
		ABC_MSH6_euk	988..1201	CDD:213253	110/221 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	175	1.000	Domainoid score	I852
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	444	1.000	Inparanoid score	I305
OMA	1	1.010	-	-		QHG53698
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto101847
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R750
SonicParanoid	1	1.000	-	-		X3037
TreeFam	1	0.960	-	-
	14	13.860