DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_034960.1	Gene:	Msh6 / 17688	MGIID:	1343961	Length:	1358	Species:	Mus musculus

Alignment Length:	1266	Identity:	524/1266 - (41%)
Similarity:	745/1266 - (58%)	Gaps:	131/1266 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GTPTNTLLNYFSKSPA---FDKKKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAAKRK 72
            |......:.:|..||.   ..|:.|.|..     .|||::..        |.|...:||....|.
Mouse   124 GKSVRVHVQFFDDSPTRGWVSKRMLKPYT-----GSKSKEAQ--------KGGHFYSSKSEILRA 175

  Fly    73 LPISDDEPASGQRKRKRIVQPESDSEPEME----------VTKSEDD------------------ 109
            :..:|:..:....:|.::...:..||||.|          ..|||:|
Mouse   176 MQRADEALSKDTAERLQLAVCDEPSEPEEEEETEVHEAYLSDKSEEDNYNESEEEAQPSVQGPRR 240

  Fly   110 ----------FSDCASD-------YEPD-ENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRKK 156
                      .||..||       ::|| :.|.|.|..|||..: |.||:..:.....||  ||:
Mouse   241 SSRQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSDDASSGVGD-SDSEDLGTFGKGAPK--RKR 302

  Fly   157 SKILNNNNNNEPSSKKVKLESTIQLAEGAT--FQEKLKNLQS-NAKQDASYDDIVTNTSN-LDEP 217
            :.:.      :...::..|:.....|:.||  ..|....|.: :|.|::.....|:...| ...|
Mouse   303 AMVA------QGGLRRKSLKKETGSAKRATPILSETKSTLSAFSAPQNSESQTHVSGGGNDSSGP 361

  Fly   218 VVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFF 282
            .||.|:.||:|:|:|.:|:..||||||:::.:||:|||:|||..:||:|:||.|||.|:|.|:|:
Mouse   362 TVWYHETLEWLKPEKRRDEHRRRPDHPEFNPTTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFY 426

  Fly   283 KVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMM 347
            |||||||||||||.:||:|||..:|:|.:||||||||:|.:.|..||.:|:|||||||||||:||
Mouse   427 KVGKFYELYHMDAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMM 491

  Fly   348 TERCKRI-KATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDEGTCSR---YG 408
            ..||::: ..:|||:||.||||:|..:|||.:.........:...|:|::.||:|.|...   ||
Mouse   492 EARCRKMAHVSKFDRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEETSGHTRVYG 556

  Fly   409 VCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEP-V 472
            |||:|||:|.|.:|:|.||::|||..|||:|:.||..|.||..||..|:.:::..|...|:|. :
Mouse   557 VCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLI 621

  Fly   473 PGNGKHACSAEKTLKLLAE-RYYAGPG-SDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQC 535
            ||:  ....|.|||:.|.| .|:.|.| |....||||:.|.|:.|.:||||.:..:|||.|||..
Mouse   622 PGS--QFWDATKTLRTLLEGGYFTGNGDSSTVLPLVLKGMTSESDSVGLTPGEESELALSALGGI 684

  Fly   536 IFFIHKCKLEPKVLPMARYQLYVP--PDQLADAKPAVASTLRRSHMVLDATTLSNLRII------ 592
            :|::.||.::.::|.||.::.|.|  .|.::..||....|.....|||||.||:||.|.
Mouse   685 VFYLKKCLIDQELLSMANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNLEIFLNGTNG 749

  Fly   593 GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPD 657
            ..|.:||..||.|.|.||||||..|||||.|..|.|.:|.||:.:|:.:|.::.||..||..:||
Mouse   750 STEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAVPDKVTEVADLLKKLPD 814

  Fly   658 FERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQ---- 718
            .||.|::||..|: .:|..:|||||||::||..|:|:|:..|::.|:||..:.|:..:..:
Mouse   815 LERLLSKIHNVGS-PLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKVSGLLEEVAGG 878

  Fly   719 --CKTTLLKRITQLPESG--GSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSI 779
              .||  ||::..|....  |.||||:.|||.:.|||||:.|.|||:|.|:||.|::||.|:..|
Mouse   879 FTSKT--LKQVVTLQSKSPKGRFPDLTAELQRWDTAFDHEKARKTGLITPKAGFDSDYDQALADI 941

  Fly   780 GEVEKRLKTYLVEQERHFGCR-ITYFGSDKKRYQLDVPESHASK-ANKSYTLEGQTKGKKPSRRY 842
            .|.|:.|..||.:|....||: |.|:|..:.||||::||:.|:: ..:.|.|:...||.|   ||
Mouse   942 RENEQSLLEYLDKQRSRLGCKSIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCK---RY 1003

  Fly   843 TTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA-GQQ 906
            .|......|.::.:||:.|:..|||..||||..|..::..|:..::|:|.||||..||.|: |..
Mouse  1004 WTKTIEKKLANLINAEERRDTSLKDCMRRLFCNFDKNHKDWQSAVECIAVLDVLLCLANYSQGGD 1068

  Fly   907 MVICVPELV--SDADQPFIQLEEGYHPCAN----ASTYIPNGLELGTASEAP------LSLLTGP 959
            ..:|.||:|  .:...||::.:...|||..    ...:|||.:.:|...||.      ..|:|||
Mouse  1069 GPMCRPEIVLPGEDTHPFLEFKGSRHPCITKTFFGDDFIPNDILIGCEEEAEEHGKAYCVLVTGP 1133

  Fly   960 NMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLI 1024
            ||||||||:|:.|||.:|||:|.::||..|||:.|||:||||||.|.|::|.|||.|||:||:.|
Mouse  1134 NMGGKSTLIRQAGLLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASI 1198

  Fly  1025 LKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLG 1088
            |:|||.|||||:|||||||||:||||||.:||..|| .:|||||||||||:|::.:.....:.||
Mouse  1199 LRHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKSVCVRLG 1263

  Fly  1089 HMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQ 1153
            |||||||||.. ||:|||:|||||:..||||||||||||:||.:|:.:|::.:..:::.|.:...
Mouse  1264 HMACMVENECE-DPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFERMNQS 1327

  Fly  1154 RKITAKIVAATAGNEDTKKEKIN--ALKDLL 1182
            .::..::..|      |:|..||  |:..||
Mouse  1328 LQLFREVCLA------TEKPTINGEAIHRLL 1352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	36/157 (23%)
		MutS	261..1186	CDD:223327	445/963 (46%)
		MutS_I	263..375	CDD:279898	70/112 (63%)
		MutS_II	391..508	CDD:282973	53/122 (43%)
		MutS_III	584..>667	CDD:282977	41/88 (47%)
		MutS_IV	767..859	CDD:282975	34/93 (37%)
		ABC_MSH6_euk	924..1140	CDD:213253	132/226 (58%)
Msh6	NP_034960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		MSH6_like	88..195	CDD:99898	16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..360		55/212 (26%)
		SEEEED	224..349	CDD:291463	38/136 (28%)
		MutS	406..1330	CDD:223327	423/931 (45%)
		MutS_I	406..524	CDD:279898	60/121 (50%)
		MutS_II	537..689	CDD:282973	62/156 (40%)
		MutS_III	736..>824	CDD:282977	37/87 (43%)
		MutS_IV	929..1021	CDD:282975	34/93 (37%)
		P-loop_NTPase	1089..1311	CDD:304359	116/210 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849360
Domainoid	1	1.000	257	1.000	Domainoid score	I2012
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	873	1.000	Inparanoid score	I409
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto94720
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R750
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800