DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh5

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001139687.1	Gene:	Msh5 / 17687	MGIID:	1329021	Length:	833	Species:	Mus musculus

Alignment Length:	863	Identity:	208/863 - (24%)
Similarity:	356/863 - (41%)	Gaps:	196/863 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGIL---- 468
            |:.:.|||....|......|....:||..|...     :|.:|.::...|....|...|.|
Mouse    61 GIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDE-----INPQSVVTSAKQDEAMTRFLGKLASEE 120

  Fly   469 -KEP-------VPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHLGLT---PN 522
             :||       :|       |.:...::..:|..:|     |:..:..:|.:....|.|:   |.
Mouse   121 HREPKGPEIILLP-------SVDFGPEISKQRLLSG-----NYSFISDSMTATEKILFLSSIIPF 173

  Fly   523 DNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRRSHMV-LDATTL 586
            | ..|.::|||..:.|:.:.::.   :.:..|.:.||   :...|..|.     :|:| :|..|.
Mouse   174 D-CVLTVRALGGLLKFLSRRRIG---VELEDYDVGVP---ILGFKKFVL-----THLVSIDQDTY 226

  Fly   587 SNLRII-GEEH--------------SLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIG 636
            |.|:|. .|.|              ||...|:.|..|:|::||..|...|:.::..:..|.|.|
Mouse   227 SVLQIFKSESHPSVYKVASGLKEGLSLFGILNRCRCKWGQKLLRLWFTRPTRELRELNSRLDVI- 290

  Fly   637 ELIRMPTEL---QEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQG 698
            :...||..|   |.:..||:.:    :|:..|       :|:|.       |...|:.:.|.|..
Mouse   291 QFFLMPQNLDMAQMLHRLLSHI----KNVPLI-------LKRMK-------LSHTKVSDWQVLYK 337

  Fly   699 FMAVLKGFNDLTKLPTMFHQCKTTLLKRITQLPESGGSFPDLSKE----LQYFATA------FDH 753
            .:....|..|         .|::        ||:|...|.|:::|    |.:.|:.      |:.
Mouse   338 TVYSALGLRD---------ACRS--------LPQSIQLFQDIAQEFSDDLHHIASLIGKVVDFEE 385

  Fly   754 DAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR----LKTYLVE---------QERHFGCRITY-- 803
            ..|.....:.|  .:|.:.||        :||    |.::|.|         ..|...|.:.|
Mouse   386 SLAENRFTVLP--NIDPDIDA--------KKRRLIGLPSFLTEVAQKELENLDSRIPSCSVIYIP 440

  Fly   804 -FGSDKKRYQLDVPESHASKANKSYTLEG-----QTKGKKPSRRYTTAETRALLKDMQHAE--DT 860
             .|     :.|.:|..........:.:||     .::.|...|...|.|...||.|: |.|  |.
Mouse   441 LIG-----FLLSIPRLPFMVEASDFEIEGLDFMFLSEDKLHYRSARTKELDTLLGDL-HCEIRDQ 499

  Fly   861 RNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAE------YAGQQMVICVPELVSDAD 919
            ..:::..|..::..:.|    ...:.:|..:.||||.:||.      |:......|:..
Mouse   500 ETLLMYQLQCQVLARAS----VLTRVLDLASRLDVLLALASAARDYGYSRPHYSPCIHG------ 554

  Fly   920 QPFIQLEEGYHP----CANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQI 980
               :::..|.||    ||.  |::||..:.| ..:..:.::||||..|||..:::|||:..||.:
Mouse   555 ---VRIRNGRHPLMELCAR--TFVPNSTDCG-GDQGRVKVITGPNSSGKSIYLKQVGLITFMALV 613

  Fly   981 GAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTAT 1045
            |:.:||....:.::|.||||:.:.:.|..|.|||:::||:.:..:.:||.|||||:||.|:||.:
Mouse   614 GSFVPAEEAEIGVIDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATEHSLVLIDEFGKGTNS 678

  Fly  1046 YDGTAIAASVVNFLANL--KCRTLF-STHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETV 1107
            .||.|:.|:|:.....|  .|..:| :|::.:|:..    :.:..|.:...:..|...|  .|.:
Mouse   679 VDGLALLAAVLRHWLALGPSCPHVFVATNFLSLVQL----QLLPQGPLVQYLTMETCED--GEDL 737

  Fly  1108 TFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKK 1172
            .|.|:...|....|:..:.|..||:|..:|.|..|:|..:.        :.|.:.||  ||..::
Mouse   738 VFFYQLCQGVASASHASHTAAQAGLPDPLIARGKEVSDLIR--------SGKPIKAT--NELLRR 792

  Fly  1173 ---EKINALKDLLKQLKM 1187
               |...||.|...:|.:
Mouse   793 NQMENCQALVDTFLKLDL 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	207/860 (24%)
		MutS_I	263..375	CDD:279898
		MutS_II	391..508	CDD:282973	22/111 (20%)
		MutS_III	584..>667	CDD:282977	27/100 (27%)
		MutS_IV	767..859	CDD:282975	25/114 (22%)
		ABC_MSH6_euk	924..1140	CDD:213253	71/222 (32%)
Msh5	NP_001139687.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		DUF3160	<65..>149	CDD:288259	19/95 (20%)
		MUTSd	252..568	CDD:214710	81/380 (21%)
		MutS_III	252..389	CDD:282977	39/172 (23%)
		MutS_III	397..495	CDD:302670	24/111 (22%)
		MutS_III	<474..535	CDD:282977	17/65 (26%)
		ABC_MSH5_euk	556..762	CDD:213248	68/214 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820