DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh3

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_034959.2	Gene:	Msh3 / 17686	MGIID:	109519	Length:	1095	Species:	Mus musculus

Alignment Length:	1251	Identity:	304/1251 - (24%)
Similarity:	510/1251 - (40%)	Gaps:	302/1251 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NTSVG-GTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASK-----SEKENLQNQQPKVKDGKKEA 64
            :|:.| |....|:|:.|.:|..    .|..|..:...|.|     |.|.:|.|..|.    ||:|
Mouse    11 STAAGPGPGRQTVLSRFFRSAG----SLRSSASSTEPAEKVTEGDSRKRSLGNGGPT----KKKA 67

  Fly    65 SKPAAKRKLPISDDE---PASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASD 126
                  ||:|..::|   .|:...:.|:.::|..       |.||.:...:...|....:|....
Mouse    68 ------RKVPEKEEENISVAAHHPEAKKCLRPRI-------VLKSLEKLKEFCCDSALPQNRVQT 119

  Fly   127 DSVSSGAEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTIQLAEGATFQEKL 191
            :::                        |::.::|....:.|        :.|:|.|:.|...|..
Mouse   120 EAL------------------------RERLEVLPRCTDFE--------DITLQRAKNAVLSEDS 152

  Fly   192 KNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEK 256
            |: |:|.| |:.:...         |.|:  ||....:|...:.|             :::.|.:
Mouse   153 KS-QANQK-DSQFGPC---------PEVF--QKTSDCKPFNKRSK-------------SVYTPLE 191

  Fly   257 FLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELG-FTYMRGEFAHSGFPEIS 320
            .         |:..:|..:.|.||..:.|..|..:..||::...||. :.::...|..:..|...
Mouse   192 L---------QYLDMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHR 247

  Fly   321 FDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIG 385
            .......||.:|:||..|:||||..:     |.|...| ..|.:|::       |.::.....||
Mouse   248 LFVHVRRLVAKGYKVGVVKQTETAAL-----KAIGDNK-SSVFSRKL-------TALYTKSTLIG 299

  Fly   386 PNHQP-------------------NYMLAIVE-------KDEGTCSRYGVCFIDTSIGDFHLGEF 424
            .:..|                   ||:|.|.|       |.:|..| .|:..:..:.|:.....|
Mouse   300 EDVNPLIRLDDSVNIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLS-VGIVGVQPATGEVVFDCF 363

  Fly   425 EDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLL 489
            :|..:...|.|.:|...||..| ..|.||..|:.:::......:::.               ::.
Mouse   364 QDSASRLELETRISSLQPVELL-LPSDLSVPTEMLIQRATNVSVRDD---------------RIR 412

  Fly   490 AERYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNY--------------------KLALKALGQ 534
            .||              :.....:..|...|..:.|                    |..:.||..
Mouse   413 VER--------------MNNTYFEYSHAFQTVTEFYAREIVDSQGSQSLSGVINLEKPVICALAA 463

  Fly   535 CIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLR--RSHMVLDATTLSNLRIIGEE-- 595
            .|.::.:..|| |:|                :||.....|.  ...|.::.|||.||.|:..:
Mouse   464 VIRYLKEFNLE-KML----------------SKPESFKQLSSGMEFMRINGTTLRNLEILQNQTD 511

  Fly   596 ----HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTEL-QEVRALLAPM 655
                .|||..|||..|.||:|.|.:|:..|...:..|..|.||:.:::...:.: :::..||..:
Mouse   512 MKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKL 576

  Fly   656 PDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTK-----LPTM 715
            ||.||.|..|:                        :.|...|.|..::|....|..     :|.:
Mouse   577 PDVERGLCSIY------------------------HKKCSTQEFFLIVKSLCQLKSELQALMPAV 617

  Fly   716 FHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIG 780
            ....::.||:.:  :.|:    |:|...::::....:..||        :.|...|....:....
Mouse   618 NSHVQSDLLRAL--IVEA----PELLSPVEHYLKVLNGPAA--------KVGDKTELFKDLSDFP 668

  Fly   781 EVEKRLKTYLVEQERHFGCRITYFGSDKK------------RYQLDVPESHASKANKSYTLEGQT 833
            .::|| |..:.|.......|:..|....|            .:.:::..|..|.....:...|.|
Mouse   669 LIKKR-KNEIQEVIHSIQMRLQEFRKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGST 732

  Fly   834 KGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRL--FEKFSNHYDQWKQCIDCVANLDVL 896
            |...........|:...|..::     ..:||...|..|  .|.|..||....:.:|.:|.:|.:
Mouse   733 KAVSRFHPPFIVESYRRLNQLR-----EQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCI 792

  Fly   897 GSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANA-----STYIPNGLELGTASEAPLSLL 956
            .|||:.| :|...|.|.|   .::..|.::.|.||..:.     ..::||...|...||. :.::
Mouse   793 FSLAKVA-KQGNYCRPTL---QEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLSQDSER-VMII 852

  Fly   957 TGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNET 1021
            |||||||||:.:::|.|:.||||||:::||....:.:||.||||:||.|:|..|.|||:.||.:|
Mouse   853 TGPNMGGKSSYIKQVALVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEELTDT 917

  Fly  1022 SLILKHATCHSLVLLDELGRGTATYDGTAIA-ASVVNFLANLKCRTLFSTHYHNLIDFFHNDK-- 1083
            :.|::.|:..|||:||||||||:|:||.||| |::..|:.::|..|||.|||..:.:.   :|
Mouse   918 AEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCEL---EKCY 979

  Fly  1084 --RITLGHMACMV----ENEDNADPTQ--ETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRA 1140
              ::...||..:|    ..:|:.|..|  ::|||||:.|.|...:|||.|.||||.:|:.::::|
Mouse   980 PEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKA 1044

  Fly  1141 YELSKKVEA-IALQRK 1155
            ...||::|. ::|:||
Mouse  1045 AHKSKELEGLVSLRRK 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	22/119 (18%)
		MutS	261..1186	CDD:223327	253/987 (26%)
		MutS_I	263..375	CDD:279898	28/112 (25%)
		MutS_II	391..508	CDD:282973	24/123 (20%)
		MutS_III	584..>667	CDD:282977	31/89 (35%)
		MutS_IV	767..859	CDD:282975	16/103 (16%)
		ABC_MSH6_euk	924..1140	CDD:213253	95/231 (41%)
Msh3	NP_034959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84		24/86 (28%)
		MutS	183..1053	CDD:223327	251/1004 (25%)
		MutS_I	188..301	CDD:279898	32/134 (24%)
		MutS_II	324..481	CDD:282973	36/204 (18%)
		MutS_III	498..>613	CDD:282977	36/138 (26%)
		MutS_III	670..755	CDD:302670	14/90 (16%)
		MutS_V	804..1052	CDD:278891	102/254 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830