DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Msh6 and Msh2

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_032654.1	Gene:	Msh2 / 17685	MGIID:	101816	Length:	935	Species:	Mus musculus

Alignment Length:	1003	Identity:	237/1003 - (23%)
Similarity:	411/1003 - (40%)	Gaps:	226/1003 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 VLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTET 343
            |..|..|.||..:..||.:...|:..|  :|...:.| |..|....|.:|....|      ::..
Mouse    34 VRLFDRGDFYTAHGEDALLAAREVFKT--QGVIKYMG-PAGSKTLQSVVLSKMNF------ESFV 89

  Fly   344 PDMMTERCKRI---------KATKFD------KVVAREICQITNRGTQVFGSQCKIGPNHQPNYM 393
            .|::..|..|:         ||:|.:      |.....:.|..:   .:||:.............
Mouse    90 KDLLLVRQYRVEVYKNKAGNKASKENEWYLAFKASPGNLSQFED---ILFGNNDMSASVGVMGIK 151

  Fly   394 LAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMP---VLFLNEKSALSQR 455
            :|:|:...    ..||.::|::.....|.||.::...|.|..|:....|   ||...|.:....:
Mouse   152 MAVVDGQR----HVGVGYVDSTQRKLGLCEFPENDQFSNLEALLIQIGPKECVLPGGETTGDMGK 212

  Fly   456 TQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWP---LVLRTMQSDMDHL 517
            .:|:::.  |||                    |:.||..|...:.|.:.   .:|:..:.:..:.
Mouse   213 LRQVIQR--GGI--------------------LITERKRADFSTKDIYQDLNRLLKGKKGEQINS 255

  Fly   518 GLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLAD----AKPAVASTLRRSH 578
            ...|....::|:.:|...|.|:                     :.|:|    .:..:|:.....:
Mouse   256 AALPEMENQVAVSSLSAVIKFL---------------------ELLSDDSNFGQFELATFDFSQY 299

  Fly   579 MVLDATTLSNLRII--------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAI 635
            |.||...:..|.:.        |.: ||.:.|:.|.|..|:||::.|:..|..|.:.|:||.:.:
Mouse   300 MKLDMAAVRALNLFQGSVEDTTGSQ-SLAALLNKCKTAQGQRLVNQWIKQPLMDRNRIEERLNLV 363

  Fly   636 GELI---RMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQ--K 695
            ...:   .:...|||  .||...||..| ||                         |.:.:|  .
Mouse   364 EAFVEDSELRQSLQE--DLLRRFPDLNR-LA-------------------------KKFQRQAAN 400

  Fly   696 LQGFMAVLKGFNDLTKLPTMF---------HQCKTTLLKRITQLPESGGSFPDLSKELQYFATAF 751
            ||....:.:|.|   :||::.         ||. ..|...:|.|.:...   |.||..:...|..
Mouse   401 LQDCYRLYQGIN---QLPSVIQALEKYEGRHQA-LLLAVFVTPLIDLRS---DFSKFQEMIETTL 458

  Fly   752 DHDAAAKTGVIAPQAGMDAEYDAAMDSIGEV----EKRLKTYLVEQERHFG------------CR 800
            |.|.......:     :...:|..:..:.||    ||::::.|:...|..|            .:
Mouse   459 DMDQVENHEFL-----VKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPGKQIKLDSSAQ 518

  Fly   801 ITYFGSDKKRYQLDVPESHASKANKSY-TLEGQTKGKKPSRRYTTAETRAL----LKDMQHAEDT 860
            ..|:      :::...|....:.||:: |::.|..|.|    :|.:|..:|    .|:....|:.
Mouse   519 FGYY------FRVTCKEEKVLRNNKNFSTVDIQKNGVK----FTNSELSSLNEEYTKNKGEYEEA 573

  Fly   861 RNMVLKDLARRLFEKFSNHYDQWKQCI-DCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQ 924
            ::.::|::.     ..|:.|.:..|.: |.:|:||.:.|.|..:....|..|..::.:..:..|.
Mouse   574 QDAIVKEIV-----NISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVILEKGKGRII 633

  Fly   925 LEEGYHPCANAS---TYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPA 986
            |:...|.|....   .:|||.:.. ...:....::||||||||||.:|:.|::|:|||||..:|.
Mouse   634 LKASRHACVEVQDEVAFIPNDVHF-EKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPC 697

  Fly   987 ASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAI 1051
            .|..:|:||.|..|:||.|..|.|.|||:.|:.||:.||:.||..||:::|||||||:||||..:
Mouse   698 ESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGL 762

  Fly  1052 AASVVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTA 1115
            |.::.:::| .:....:|:||:|.|....:....:...|:..:.        |:||:|.||:...
Mouse   763 AWAISDYIATKIGAFCMFATHFHELTALANQIPTVNNLHVTALT--------TEETLTMLYQVKK 819

  Fly  1116 GACPKSYGFNAAKLAGMPQGII----KRAYELS-------------------------KKVEAIA 1151
            |.|.:|:|.:.|:||..|:.:|    ::|.||.                         ::.|.|.
Mouse   820 GVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQNIGTSLGCDEAEPAAKRRCLEREQGEKII 884

  Fly  1152 LQRKITAKIVAATAGNEDTKKEKINALK 1179
            |:.....|.|..||.:|::...|:..||
Mouse   885 LEFLSKVKQVPFTAMSEESISAKLKQLK 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511
		MutS	261..1186	CDD:223327	237/1003 (24%)
		MutS_I	263..375	CDD:279898	24/110 (22%)
		MutS_II	391..508	CDD:282973	24/122 (20%)
		MutS_III	584..>667	CDD:282977	26/93 (28%)
		MutS_IV	767..859	CDD:282975	20/112 (18%)
		ABC_MSH6_euk	924..1140	CDD:213253	82/223 (37%)
Msh2	NP_032654.1	MutS_I	18..132	CDD:279898	24/106 (23%)
		MutS	26..853	CDD:223327	226/942 (24%)
		MutS_II	152..284	CDD:282973	32/178 (18%)
		MutS_III	305..>423	CDD:282977	34/149 (23%)
		MutS_IV	473..569	CDD:282975	20/105 (19%)
		Interaction with EXO1. /evidence=ECO:0000250	601..671		15/70 (21%)
		ABC_MSH2_euk	633..852	CDD:213252	84/227 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820