DRSC/TRiP Functional Genomics Resources

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Protein Alignment Msh6 and him-14

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_495451.1 Gene:him-14 / 174157 WormBaseID:WBGene00001872 Length:842 Species:Caenorhabditis elegans


Alignment Length:897 Identity:212/897 - (23%)
Similarity:362/897 - (40%) Gaps:207/897 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 MLAIVEKDEGTCSRY-GVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHH----MPVLFLNEKSAL 452
            ::.:|.:..|:|..: |:...||...:.||.||.|.:..:.|.|:::.|    :.:...||:...
 Worm    53 VVIVVMEGRGSCEGHIGIALHDTCFPEIHLCEFVDSREYTTLKTMINVHEAFDIVIQNGNEERGS 117

  Fly   453 SQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYYAGPGSDDNWPLVLRTMQSDMDHL 517
            ::        :||..|....|         |.:|:.::.:|:.....:       |.:||.|:..
 Worm   118 TK--------LLGEALMTAFP---------EASLQSISSKYFNSERGE-------RQLQSLMNAE 158

  Fly   518 GLTPND---NYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLR---- 575
            ..|.::   ...|||.||...:.:||:.:.           ::.....|...:..|..|..    
 Worm   159 VSTVSEGCLRRTLALGALAVLLKYIHETRC-----------VFFRVKSLRIKEMGVNDTCMIDFV 212

  Fly   576 --RSHMVLDATTLSNLR--IIGEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIG 636
              .|..::||...|..|  .:.::.:|:|.|:|..|..|.|||...:..||.||.:|:.||:||.
 Worm   213 SWESLEIVDADDASKARKFQMKQKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIE 277

  Fly   637 ELIRMPTELQEVRALLAPMPDFERNLAQ-IHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQGFM 700
            |||..|....::|..|:...:.:|.:|. |....:..:::.          |.|:....||...:
 Worm   278 ELIGKPQLKDKLRRTLSRAHELDRVIAMCIQTSTSWTVRES----------EAKINQIIKLMHTL 332

  Fly   701 AVLKGFNDLTKLPTMFHQC---------KTTLLK--RITQL-----PESGGSFPDLSKE------ 743
            .|::|      :.|:.|..         ||..||  |..|:     .:...|..|..|.      
 Worm   333 KVIQG------IRTLLHSAKMKSNILIEKTEFLKDPRFDQIMNILVEKVDDSLLDGKKNSLHLQN 391

  Fly   744 -----LQYFATAFDHDAAAKT------GVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHF 797
                 :::| .|...|.|.:|      .|....|...|||.....|:     ||.   ..|.|  
 Worm   392 TKCYAIRHF-VAVQLDLARQTYEEIIRNVEETGAREIAEYFHGNSSV-----RLS---FSQSR-- 445

  Fly   798 GCRITYFGSDKK-----RYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETR--ALLKDMQ 855
            |...|:.....:     ||.|||             ...:|.....||:......|  .::.:|.
 Worm   446 GFHYTFVTRQAESVTIPRYFLDV-------------FRNRTTVTFNSRKVIAYNDRLEQVVAEMF 497

  Fly   856 HAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQ 920
            .|.|   :::.|:...:.......|    ..:|.::::|.|..||.|:..:.. |.|..     .
 Worm   498 LASD---VIVCDMIEEMQPMIPVLY----YAMDALSSIDFLCGLATYSDLRDT-CKPTF-----G 549

  Fly   921 PFIQLEEGYHPCA---NASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGA 982
            |...:.:|.||..   ::...|.|...|  ..:....::|||||.||||.:::...|.||||||.
 Worm   550 PSFSISQGRHPILDWDDSEKTITNDTCL--TRDRRFGIITGPNMAGKSTYLKQTAQLAIMAQIGC 612

  Fly   983 HIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYD 1047
            .|||....|.:.:|||:|:|..|:::...|.|..|:::.:.|:::|..:|||:||||.|.|:|.:
 Worm   613 FIPANYASLPIFNRIFSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEE 677

  Fly  1048 GTAIAASVVNFLANLKCRTLFSTH---------YHNLIDFFHNDKRITLGHMACMVENEDNADPT 1103
            |.||..::...:..|:..|..:||         |.|.||.:|           .:.:.::|:...
 Worm   678 GIAITYAICEKVLKLQSYTFLATHFLDIAALANYSNAIDNYH-----------FLPQTDENSTKK 731

  Fly  1104 QETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKVEA---------IALQRKI--- 1156
            .:.:...|:      ...|||...:|:.:|..:|:.|..|:.::.|         .:.:|:|   
 Worm   732 HKLLRGQYR------GPLYGFELVELSTIPDEVIEHAQSLATELRANVEDTERDYDSERRRIKVY 790

  Fly  1157 -------TAKIVAATAGNE-DTKKEKINALKDLLKQL-----------KMCQ 1189
                   .|:....|.|.: ..:||.|:.:|.|.|.|           :|||
 Worm   791 MNHRFRECAEYFMDTHGEKWKEEKEAIDKMKALRKYLVDELAKIDSQEQMCQ 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511
MutS 261..1186 CDD:223327 209/892 (23%)
MutS_I 263..375 CDD:279898
MutS_II 391..508 CDD:282973 23/119 (19%)
MutS_III 584..>667 CDD:282977 29/85 (34%)
MutS_IV 767..859 CDD:282975 21/98 (21%)
ABC_MSH6_euk 924..1140 CDD:213253 67/227 (30%)
him-14NP_495451.1 MutS_III 215..>304 CDD:282977 30/88 (34%)
MUTSd 236..565 CDD:214710 87/381 (23%)
ABC_MSH4_euk 553..753 CDD:213249 65/218 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138168at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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