DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Msh6 and msh-2

DIOPT Version :9

Sequence 1:NP_648755.1 Gene:Msh6 / 39654 FlyBaseID:FBgn0036486 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_491202.1 Gene:msh-2 / 171938 WormBaseID:WBGene00003418 Length:849 Species:Caenorhabditis elegans


Alignment Length:1008 Identity:228/1008 - (22%)
Similarity:388/1008 - (38%) Gaps:294/1008 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 VLKSDNYDCVLFFKVGKFYELYHMDA----------DVGVNELGFTYMRGEFAHSGFPEISFD-- 322
            :|||.:.:.:..|..|:::.:|..||          ||.|..  ||             :|.|  
 Worm    16 ILKSKSPNTIAIFSRGEYFSVYGDDATFVATNIFKSDVCVKT--FT-------------LSTDNS 65

  Fly   323 -KMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREI----CQI------------ 370
             :|..|.|:||                         :::|||...|    |.:            
 Worm    66 QQMKYISVNRG-------------------------QYEKVVRETIVLLRCSVELYSSEQGEWKM 105

  Fly   371 TNRGT--QVFGSQCKIGPNHQPNYMLAIVEKDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRL 433
            |.||:  .....:.:||.:.|.. :|||........:|..:|..|.......:.|:.|..:.|:.
 Worm   106 TKRGSPGNTVDFEQEIGVSDQAP-ILAIYIHPGDDDNRVTLCAWDAGNVRIVISEYIDTPSFSQT 169

  Fly   434 LTLVSHHMPV--LFLNEKSALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLA-----E 491
            ...:....|.  :.:||                           |..|..|:|...:..     .
 Worm   170 EQCIFGLCPTEYILVNE---------------------------GSVAPKAKKIASMFTRMEVHN 207

  Fly   492 RYYAGPGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQL 556
            :....|.|  .|..|:.::..|........|:|.|       :|:..:|....:       .|.:
 Worm   208 KQQLKPKS--QWSDVIESVHLDYKDEAEKQNENIK-------ECLQILHSNAAD-------EYSI 256

  Fly   557 YVPPDQLADAKPAVASTLRRSHMVLDATTLSNLRII---------GEEHSLLSTLDHCCTKFGKR 612
                    ..|.::.:.....:|::|:..:..|.:.         ....:|.:.|:.|.|..|::
 Worm   257 --------SEKYSIFNYGTHGNMLIDSCAVEALELFQLNYNYLEKSNNLTLYNVLNKCKTLPGEK 313

  Fly   613 LLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVR-ALLAPMPDFERNLAQIHLFGNKQIKQM 676
            ||..||..|.|.:..|.||.|.:..|....|..|::| ::||.|||..: ||:            
 Worm   314 LLRDWLSRPLCQIDHINERLDIVEALFENQTIRQKLRDSILARMPDCSQ-LAR------------ 365

  Fly   677 DHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQCKT---TLLKRITQLPESGGSFP 738
                        :|..|..||          ||.:    |:|..|   |:..::.||.|:....|
 Worm   366 ------------RLMRKCTLQ----------DLNR----FYQAATLLETVEMQLIQLSEAEQFAP 404

  Fly   739 DLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITY 803
            .:::.|:                               ..|.|:.|:::.:.|..:..|.  ..|
 Worm   405 SINRLLK-------------------------------SEITEILKKVERFQVLCDEFFD--FDY 436

  Fly   804 FGSDKK-RYQLD-VPESH------------ASKANKSYTLEGQTKGKKPSR--------RYTTAE 846
            ...:|: |.::| |||..            |.|..|.|:.:.:....|..:        |.|..|
 Worm   437 EKENKEIRVRVDFVPEIQEISEKLEQMERVAEKLRKKYSAKFECDNLKLDKNSQYGFYFRVTLKE 501

  Fly   847 TRAL-LKDMQHAEDTRNMVLKDLARRL------FEKFSNHYDQWKQCI----------------- 887
            .::: .||:...|.|:...:|.....|      |.:|...|.:.::.:                 
 Worm   502 EKSIRKKDVHILETTKGSGVKFSVGELSDINDEFLEFHLKYTRAEEEVISMLCKKAEEFIPLIPA 566

  Fly   888 --DCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHPCANAST---YIPNGLELGT 947
              ..:|.|||..||:.:|.....|.....:.......::|::..||....::   :|||.:.|  
 Worm   567 MAQLIATLDVFVSLSTFAATSSGIYTRPNLLPLGSKRLELKQCRHPVIEGNSEKPFIPNDVVL-- 629

  Fly   948 ASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHS 1012
             .:..|.:|||.|||||||.:|...|.:::||||:.:|.:|..:|:||.||||:||.|....|.|
 Worm   630 -DKCRLIILTGANMGGKSTYLRSAALSILLAQIGSFVPCSSATISVVDGIFTRVGASDKQSQGIS 693

  Fly  1013 TFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLAN-LKCRTLFSTHYHNLI 1076
            ||:.|:.:.|.||:.||.:|.|::|||||||:|:||..||:::...:.| ::|.::|:||:|.:.
 Worm   694 TFMAEMLDCSAILQRATKNSFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMG 758

  Fly  1077 DFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGIIKRAY 1141
            ........:.| .|...:||.:        :..|||...|....|:|...||:.|:.:.:|.:|.
 Worm   759 KLAEQPGAVAL-QMGVQIENNE--------IHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAA 814

  Fly  1142 ELSKKVEAIALQRKITAKIVAATAGNEDTKKEK 1174
            :|.:     .|::|:..          |:||:|
 Worm   815 QLLE-----GLEKKLVI----------DSKKKK 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Msh6NP_648755.1 MttA_Hcf106 <44..156 CDD:294511
MutS 261..1186 CDD:223327 228/1008 (23%)
MutS_I 263..375 CDD:279898 27/133 (20%)
MutS_II 391..508 CDD:282973 20/123 (16%)
MutS_III 584..>667 CDD:282977 27/92 (29%)
MutS_IV 767..859 CDD:282975 22/114 (19%)
ABC_MSH6_euk 924..1140 CDD:213253 80/219 (37%)
msh-2NP_491202.1 MutS 17..847 CDD:223327 228/1007 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0249
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D122599at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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