DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and msh-6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_491163.1	Gene:	msh-6 / 171914	WormBaseID:	WBGene00003422	Length:	1186	Species:	Caenorhabditis elegans

Alignment Length:	1238	Identity:	433/1238 - (34%)
Similarity:	666/1238 - (53%)	Gaps:	105/1238 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKKLNTSVGGTPTNTLLNYFSKSPAFDKKKLTPSVKTDPDASKSEKENLQNQQPKV-KDGKKEA 64
            |||:         .::|:::|:|:|..:|.:  ..||   :.|..|.::|:|..||: .|.:|:.
Worm     1 MSKR---------QSSLMSFFTKTPKSEKPE--EEVK---EKSVEEPKSLKNDTPKISNDSEKKV 51

  Fly    65 SKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDS- 128
            .|.:..:.:......|.:..::.|.:|...|:.|        :||..:.....|.:|:|:||:|
Worm    52 LKRSNSKTVSSPVKTPRNASKRPKVVVCSSSEGE--------DDDGDEDFEMKEAEEHESSDESE 108

  Fly   129 VSSGAEEVSPSENDMSVDSPTPKKSRKK--SKILNNNNNNEPSSKKV--KLESTIQLAEGATFQE 189
            ....|.:....|:..|....|||:..||  ||.|...|.  |.|.|:  |.:..|...|..:...
Worm   109 ADENASDCEVVESPESTPQSTPKRGGKKKISKPLLAENT--PKSVKMAGKSKKVIPDGEAVSMAG 171

  Fly   190 KLKNLQSNAKQDASYDDIVTNTSNLDEPVV-------WPHQKLEFLQPDKIKDKEGRRPDHPDYD 247
            .|..:......:.....||..|:......|       :.|:..:||:||||:|...|....|:||
Worm   172 VLDKMDKIMDGEGERKRIVEKTTGAKNKAVELEPAERFDHESFDFLKPDKIRDGFKRPMSDPEYD 236

  Fly   248 KSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFA 312
            ..||.||..|....:||.||||.:||.::|.:|.||||||||.|||||...|..|...:|||.:|
Worm   237 PKTLWVPPDFHQKQTPGHRQWWTMKSQHFDTILLFKVGKFYETYHMDAVEVVRALNIAFMRGSYA 301

  Fly   313 HSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRIKATKFDKVVAREICQITNRGTQV 377
            |:||||.:..|.:..|::.|:||||:||||||.|:.||.::.| || :|||.||:|::|:.||:.
Worm   302 HAGFPEHAASKFADQLMNHGYKVARIEQTETPQMLEERNQKTK-TK-EKVVRREVCRVTSNGTRT 364

  Fly   378 FG---------SQCKIGPNHQPNYMLAIVE--KDEGTCSRYGVCFIDTSIGDFHLGEFEDDKNCS 431
            :|         :...:.|.  ..::|||.|  ..|...|.||||.|||:.....:|:||||...|
Worm   365 YGVLDGVDLGSASSTLDPT--AKHLLAIKEFHNPETGKSSYGVCMIDTTTAHIRIGQFEDDDYRS 427

  Fly   432 RLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGI-LKEPVPGNGKHACSAEKTLKLLA-ERYY 494
            :|.||:::.:.|..:.|:.::|..|:.|:..:|..: ::..:|  .|...:||..::::: |.||
Worm   428 QLRTLLANVIVVQAIVERGSISSTTKSIINGILFSVPVEHLLP--KKQFMTAEDVVRIVSNEDYY 490

  Fly   495 AGPGSD-DNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYV 558
               ||| ..||.||:.|..|...|. .|:.:::|||.|.|...:::....::..:|.|....:|.
Worm   491 ---GSDASEWPEVLKGMLEDSSILP-KPSTDWQLALSAFGAIFWYLRDSLIDVDMLSMRNVTIYN 551

  Fly   559 PPDQLADAKPAVASTLRRSHMVLDATTLSNLRII---GEEH--SLLSTLDHCCTKFGKRLLHHWL 618
            ......|.|..... ....:::||.|.|.||.|:   .:.|  ||...::.|.|.||:|||..||
Worm   552 SNSMENDQKKEKID-WNGKNLILDGTALENLNIVPNGRDSHLTSLYYVINKCSTPFGRRLLRSWL 615

  Fly   619 CAPSCDVSVIKERQDAIGELIRMPTE--LQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDS 681
            ..|:||...:::||.||..|:.....  :....|.|..:||.:|.|.:||..|.| .:...||||
Worm   616 LQPTCDPKKLEQRQKAIKWLVSPDASSFMTTATATLKKIPDLDRLLQKIHTIGLK-YRSEKHPDS 679

  Fly   682 RAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMF-------HQCKTTLLKRITQLPESGGSFPD 739
            |||.|:....|::|:...:|.:.||....||...:       ..|:.     :.:|..:.....:
Worm   680 RAIFFDTIKTNQKKIAELLAAIDGFKLCNKLRKEYIKVQKEGEGCEL-----LDELLGNEQEMEE 739

  Fly   740 LSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCRITYF 804
            :.:.:.:|...||...|.|.|.|.|.||.|.|||.|::.:.|....|..|.....:.:.|.|.:.
Worm   740 VDENIYFFEKMFDRSTAMKDGKIVPNAGCDEEYDEALNRVKEALNELNDYKDSVAKKYSCSIKFV 804

  Fly   805 GSDKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLA 869
            .|.|.:|.|::||:  :|.:.|:.|:.:.||   ..||:|.::..|:..:...|..::.:..|..
Worm   805 DSGKVKYLLEMPEN--TKVSSSFELKSRRKG---FIRYSTPDSEQLVAALDAVEKEKSKLGDDAT 864

  Fly   870 RRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA-GQQMVICVPELVSDADQPFIQLEEGYHPC- 932
            ||:||:|.:....|.:.:..|::.|||.|||.:| .....:|:||...:|..|::.:::|.|||
Worm   865 RRVFEQFGHKNPIWLETVKLVSSFDVLTSLALFAKSSPFEMCMPEFDFNATDPYLIVDKGVHPCL 929

  Fly   933 --------ANASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASC 989
                    ...:::|.|...:| ||||.:.|||||||||||||||:..:|.|:|.||:.:||.|.
Worm   930 ALQSRNEVTQTTSFIANSTTMG-ASEAAVMLLTGPNMGGKSTLMRQTAVLAILAHIGSMVPAFSM 993

  Fly   990 RLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAAS 1054
            ||:.:||||||:||.|.|:.|.|||.:||.||.::||:||.|||:|:|||||||:|:||||||::
Worm   994 RLTPIDRIFTRIGANDRIMCGESTFFIELKETDIMLKNATKHSLLLVDELGRGTSTFDGTAIASA 1058

  Fly  1055 VVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGAC 1118
            |:..:: :|.|||.||||||::.|.|.|...:.|.||.|:|:.|:|.|||.|.|||||:..:|.|
Worm  1059 VLQKISDDLACRTFFSTHYHSICDSFTNHPNVRLAHMKCVVDKENNEDPTMEDVTFLYELESGIC 1123

  Fly  1119 PKSYGFNAAKLAGMPQGIIKRAY-ELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLL 1182
            ||||||.||||||:...:::.|| |.:|....:.:..||...:..|...|.|     :..||.::
Worm  1124 PKSYGFYAAKLAGIDHQVVRNAYLESNKFASNLIIDPKIRHLVECARDDNFD-----VGELKRMI 1183

  Fly  1183 KQL 1185
            :.:
Worm  1184 EAI 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	27/113 (24%)
		MutS	261..1186	CDD:223327	361/965 (37%)
		MutS_I	263..375	CDD:279898	60/111 (54%)
		MutS_II	391..508	CDD:282973	41/121 (34%)
		MutS_III	584..>667	CDD:282977	32/89 (36%)
		MutS_IV	767..859	CDD:282975	26/91 (29%)
		ABC_MSH6_euk	924..1140	CDD:213253	120/225 (53%)
msh-6	NP_491163.1	MutS	251..1145	CDD:223327	350/916 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166514
Domainoid	1	1.000	233	1.000	Domainoid score	I1362
eggNOG	1	0.900	-	-		E1_COG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	666	1.000	Inparanoid score	I389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto19791
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R750
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800