Protein Alignment Msh6 and msh3

DIOPT Version :9

• Sequence 1: NP_648755.1
• Gene: Msh6 / 39654
• FlyBaseID: FBgn0036486
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_002942407.2
• Gene: msh3 / 100486354
• XenbaseID: XB-GENE-1014070
• Length: 1077
• Species: Xenopus tropicalis
• Alignment Length: 1186
• Identity: 292/1186 - (24%)
• Similarity: 503/1186 - (42%)
• Gaps: 244/1186 - (20%)

  Fly   117 YEPDENEASDDSVSSG--AEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLESTI 179
            :.|.|.:.|....||.  .:....:..|.|..|..|.|.|.||     ...||    .:...||:
 Frog    23 FRPKEGDGSQPCTSSAFFPKHSRCNSRDDSPHSEEPTKKRAKS-----GEGNE----SIASTSTV 78

  Fly   180 QLAE------GATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQP-DKIKDKE 237
            :.|:      .:....|||...|...|        :|::.:.|.:.      |.||| ...||..
 Frog    79 RAADPNKPLISSQTLHKLKEFCSETGQ--------SNSNAVFENIP------ECLQPWSSFKDFA 129

  Fly   238 GRRPDHPDYDKSTLHVPEKFLNGLSPGVR------------------------QWWVLKSDNYDC 278
            |::...|:...|......:.:.|.|..::                        |:..:||.:.|.
 Frog   130 GKQEITPENGGSHSSFGLENVKGRSSSLKNSENPGEMKMPCRRTKSIYTPLEEQYMEIKSHHTDA 194

  Fly   279 VLFFKVGKFYELYHMDADVGVNELG-FTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTE 342
            :|..:.|..|..:..||::...||. :.:|...|..:..|..........||.:|:||..|:|||
 Frog   195 ILCVECGYKYRFFGEDAEIASRELNIYCHMDHNFMTASIPAHRLFVHVRRLVAKGYKVGVVKQTE 259

  Fly   343 TPDMMTERCKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQP----------------- 390
            |..:  :.....|::.|           |.:.|.::.....||.:..|
 Frog   260 TAAL--KAAGESKSSLF-----------TRQLTALYTKSTLIGEDVSPLINIDDSLEVECIMADV 311

  Fly   391 --NYMLAIVEKDEGTCSR------YGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLN 447
              :|:|.|.|..:.|.::      :|:..:..|.|:.....|.|.|:.:.|.|.:....||..|
 Frog   312 PSSYLLCIFENIDRTKNKKSADAVFGLVAVQPSTGEVMYDRFHDTKSRTELETRILRLQPVEIL- 375

  Fly   448 EKSALSQRTQQIVRTVLGGILKEP----VPGNGKHACSAEKTLKLLAERY----YAGPGSDDNWP 504
            ..|.:|..|::::.::....|::.    :....|......:..:|::|.|    :...||..
 Frog   376 LPSDISDCTERLISSLTSASLRDDDRIRIERMDKSHFEYSQAFQLISEFYGQEQHISAGSQK--- 437

  Fly   505 LVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPA 569
             :...:..|            |..:.:|...|.::.:..|| |:              |.::...
 Frog   438 -LTEILTFD------------KSVICSLAATIKYLKEFHLE-KI--------------LYNSSNF 474

  Fly   570 VASTLRRSHMVLDATTLSNLRIIGEE------HSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVI 628
            ...:.:...:.::.|||.||.|:..:      .||:..|||..|.||:|.:..|:..|..:...|
 Frog   475 TQMSSKNECLRMNGTTLKNLEILQNQTDLKTKGSLIWVLDHTRTCFGRRKIKQWVTQPLVNTREI 539

  Fly   629 KERQDAIGELIRMPTEL-QEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYN 692
            ..|.:|:.|::...:.: .:||:.|:.:||.||.:..|:                        :.
 Frog   540 NARLEAVSEVLLSDSSVFTQVRSHLSKLPDLERGVCSIY------------------------HK 580

  Fly   693 KQKLQGFMAVLKGFNDLTK-----LPTMFHQCKTTLLKRITQLPESGGSFPDLSKELQYFATAFD 752
            |...|.|..::....:::.     :|.:..|.|:.||:.|.      ...|.:.:.:..|....:
 Frog   581 KCSTQEFFLIVSTLCNISNNMEALIPAIKSQVKSPLLQTIF------AEIPQMLEPMHKFLNVLN 639

  Fly   753 HDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKR---LKTYLVEQERHFGCRITYFGSDKKRYQLD 814
            ..||        :.|...|....:....::..|   ::..|::.|.|.|        |.::...:
 Frog   640 ESAA--------RTGNKTELFKDLTDFPKISARKLEIQEMLLKLEAHLG--------DIRKILKN 688

  Fly   815 VPESHASKANKSYTLEGQTK--GKKPSRRYTTAETRA--------LLKDMQHAEDTRNMVLKDLA 869
            ...|:.|...:.:.:|.:..  ...|....|.:.|:|        ::::.:|....|..::.|..
 Frog   689 PAASYTSVYGQEFLIEVKNSLGSVVPPDWITVSSTKAVSRFHSPFIVENYRHLNQLREKLVLDCN 753

  Fly   870 R---RLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYAGQQMVICVPELVSDADQPFIQLEEGYHP 931
            .   ...:||..:|....:.|:.:|..|.:.||||.| :|...|.| .|.|:....| ::.|.||
 Frog   754 TEWLHFLDKFGENYHSVCKSINHLATADCIFSLAEVA-KQDGYCRP-AVHDSGSEII-IKNGRHP 815

  Fly   932 CAN-----ASTYIPNGLELGTASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRL 991
            ..:     .|.::||...| .|.:..:.::|||||||||:.:::|.|:.||||||:::||.:..:
 Frog   816 VIDLLLEEQSQFVPNSTSL-MADKERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEAVTV 879

  Fly   992 SLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVV 1056
            .:||.||||:||.|:|..|.|||:.||.:|:.|||:||..|||:||||||||:|:||.|||.|.:
 Frog   880 GIVDGIFTRMGAADNIYKGRSTFMDELLDTAEILKNATPRSLVILDELGRGTSTHDGIAIAYSTL 944

  Fly  1057 NF-LANLKCRTLFSTHYHNLIDFFHNDK----RITLGHMACMVENEDNADPTQET------VTFL 1110
            .: :.::...|||.|||.:|.:.   :|    ::...|||..|:.|::.|...|:      ||||
 Frog   945 EYIIKSVTSLTLFVTHYPSLCEL---EKAYAEQVGNYHMAFFVDEEEDTDSGAESLQQPQHVTFL 1006

  Fly  1111 YKYTAGACPKSYGFNAAKLAGMPQGIIKRAYELSKKV-EAIALQRKITAKIVA-ATAGNEDTKKE 1173
            |:.|.|...:|||.|.||||.:|..::.||...||.: |.:.::||   |:.| .:|.|
 Frog  1007 YQITQGIAARSYGLNVAKLADIPHSVVTRAACKSKALEELVEMKRK---KLKAFQSAWN------ 1062

  Fly  1174 KINALKDLLKQLKMCQ 1189
             ||:.::|.:.|::.|
 Frog  1063 -INSSEELKEWLEIIQ 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	11/40 (28%)
		MutS	261..1186	CDD:223327	255/1028 (25%)
		MutS_I	263..375	CDD:279898	27/136 (20%)
		MutS_II	391..508	CDD:282973	26/130 (20%)
		MutS_III	584..>667	CDD:282977	29/89 (33%)
		MutS_IV	767..859	CDD:282975	16/104 (15%)
		ABC_MSH6_euk	924..1140	CDD:213253	98/231 (42%)
msh3	XP_002942407.2	MutS	178..1072	CDD:223327	254/1001 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138168at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010