DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msh6 and Msh6

DIOPT Version :9

Sequence 1:	NP_648755.1	Gene:	Msh6 / 39654	FlyBaseID:	FBgn0036486	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_038968982.1	Gene:	Msh6 / 100360342	RGDID:	2322311	Length:	1368	Species:	Rattus norvegicus

Alignment Length:	1193	Identity:	514/1193 - (43%)
Similarity:	720/1193 - (60%)	Gaps:	99/1193 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ASKSEKENLQNQQPKVKDGKKEASKPAAKRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKS 106
            :.|||:||        :|..:|.::|.|:      ....:|.|.|::|::   ||         |
  Rat   226 SDKSEEEN--------QDESEEETQPNAQ------GPRRSSRQVKKRRVI---SD---------S 264

  Fly   107 EDDFSDCASDYEPD-ENEASDDSVSSGAEEVSPSENDMSVDSPTPKKSRK-------KSKILNNN 163
            |.|......:::|| :.|.|.|.||||..: |.||...|.....||:.|.       |.|.|...
  Rat   265 ESDIGGSDVEFKPDSKQEGSSDEVSSGVGD-SDSEGLGSFGKGAPKRKRTVAAHGGLKRKSLKKE 328

  Fly   164 NNNEPSSKKVKLESTIQLAEGATFQEKLKNLQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFL 228
            ..:...:.::..|:...|:.....|           ...|...:....::...|.:|.|:.||:|
  Rat   329 TGSAKQATRILSETKSTLSAFCAPQ-----------NSESQTHVCGGGNDSSGPTIWYHETLEWL 382

  Fly   229 QPDKIKDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHM 293
            :|:|.:|:..||||||||:.|||:|||.|||..:||:|:||..||.|:|.|:|:|||||||||||
  Rat   383 KPEKRRDENRRRPDHPDYNSSTLYVPEDFLNSCTPGMRRWWQFKSQNFDLVIFYKVGKFYELYHM 447

  Fly   294 DADVGVNELGFTYMRGEFAHSGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTERCKRI-KAT 357
            ||.:||:|||..:|:|.:||||||||:|.:.|..||.:|:|||||||||||:||..||::: ..:
  Rat   448 DAVIGVSELGLIFMKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVS 512

  Fly   358 KFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEKDE---GTCSRYGVCFIDTSIGDF 419
            |||:||.||||:|..:|||.:.........:...|:|::.||:|   |....|||||:|||:|.|
  Rat   513 KFDRVVRREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEDSSGHMRAYGVCFVDTSLGKF 577

  Fly   420 HLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQIVRTVLGGILKEP-VPGNGKHACSAE 483
            .||:|.||::||||.|||:|:.||..|.||..||..|:.:::..|...|:|. :||:  ....|.
  Rat   578 FLGQFSDDRHCSRLRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGS--QFWDAT 640

  Fly   484 KTLKLLAE-RYYAG-PGSDDNWPLVLRTMQSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEP 546
            |||:.|.| .|:.| .||....|.||:.|.|:.|.:||||.:..:|:|.|||.|:|::.||.::.
  Rat   641 KTLRTLLEGGYFTGNEGSGAELPPVLKAMTSESDSVGLTPGEESELSLSALGGCVFYLKKCLIDQ 705

  Fly   547 KVLPMARYQLYVP--PDQLADAKPAVASTLRRSHMVLDATTLSNLRII------GEEHSLLSTLD 603
            ::|.||.::.|.|  .|.:...||....|.....|||||.|||||.|.      ..|.:||..||
  Rat   706 ELLSMANFEEYFPLDSDMVGTVKPGAVFTKASQRMVLDAVTLSNLEIFLNGTNGSTEGTLLERLD 770

  Fly   604 HCCTKFGKRLLHHWLCAPSCDVSVIKERQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLF 668
            .|.|.||||||..|||||.|..|.|.:|.|||.:|:.:|.::.||..||..:||.||.|::||..
  Rat   771 TCHTPFGKRLLKQWLCAPLCSPSAISDRLDAIEDLMAVPDKVAEVADLLKKLPDLERLLSKIHNV 835

  Fly   669 GNKQIKQMDHPDSRAILFEEKLYNKQKLQGFMAVLKGFNDLTKLPTMFHQC----KTTLLKRITQ 729
            |: .:|..:|||:|||::||..|:|:|:..|::.|:||..:.|:..:....    |:..||::..
  Rat   836 GS-PLKSQNHPDTRAIMYEETTYSKKKIIDFLSALEGFKVMCKITRLMEDVADGFKSKTLKQVVT 899

  Fly   730 LPESG--GSFPDLSKELQYFATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVE 792
            |....  |.||||:.||..:.|||||:.|.|||:|.|:||.|::||.|:..|.|.|:.|..||.:
  Rat   900 LQTKSPKGRFPDLTAELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDK 964

  Fly   793 QERHFGCR-ITYFGSDKKRYQLDVPESHASK-ANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQ 855
            |....||| |.|:|..:.||||::||:.|:: ..:.|.|:...||.|   ||.|......|.::.
  Rat   965 QRSRIGCRNIVYWGIGRNRYQLEIPENFATRNLPEEYELKSTKKGCK---RYWTKVIEKKLSNLI 1026

  Fly   856 HAEDTRNMVLKDLARRLFEKFSNHYDQWKQCIDCVANLDVLGSLAEYA-GQQMVICVPELV--SD 917
            :||:.|:..|||..||||..|..::..|:..::|.|.||||..||.|: |....:|.|.|:  .:
  Rat  1027 NAEERRDASLKDCMRRLFYNFDKNHKDWQSAVECTAVLDVLLCLASYSQGGDGPMCRPVLLLPGE 1091

  Fly   918 ADQPFIQLEEGYHPCAN----ASTYIPNGLELGTASEAPLS------LLTGPNMGGKSTLMREVG 972
            ...||::|:...|||..    ...:|||.:.:|...:|...      |:|||||||||||:|:.|
  Rat  1092 DTHPFLELKGSRHPCITKTFFGDDFIPNDILIGCEEDAEADGKAYCVLVTGPNMGGKSTLIRQAG 1156

  Fly   973 LLVIMAQIGAHIPAASCRLSLVDRIFTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLD 1037
            ||.:|||:|.::||..|||:.|||:||||||.|.|::|.|||.|||:||:.||:|||.|||||:|
  Rat  1157 LLAVMAQMGCYVPAELCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATAHSLVLVD 1221

  Fly  1038 ELGRGTATYDGTAIAASVVNFLA-NLKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNAD 1101
            ||||||||:||||||::||..|| .:|||||||||||:|::.:..:..:.|||||||||||.. |
  Rat  1222 ELGRGTATFDGTAIASAVVKELAETIKCRTLFSTHYHSLVEDYSKNVCVRLGHMACMVENECE-D 1285

  Fly  1102 PTQETVTFLYKYTAGACPKSYGFNAAKLAGMPQGII----KRAYELSKKVEAIALQRKITAKIVA 1162
            |:|||:|||||:..||||||||||||:||.:|:.:|    ::|.|..:..:|:.|.|:     |.
  Rat  1286 PSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFERMNQALQLFRE-----VC 1345

  Fly  1163 ATAGNEDTKKEKINALKDLLKQL 1185
            ..:.......|.|:.|..|:.||
  Rat  1346 LASERPTVNSEAIHRLLALVNQL 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	34/119 (29%)
		MutS	261..1186	CDD:223327	447/966 (46%)
		MutS_I	263..375	CDD:279898	69/112 (62%)
		MutS_II	391..508	CDD:282973	54/122 (44%)
		MutS_III	584..>667	CDD:282977	43/88 (49%)
		MutS_IV	767..859	CDD:282975	35/93 (38%)
		ABC_MSH6_euk	924..1140	CDD:213253	132/230 (57%)
Msh6	XP_038968982.1	MSH6_like	93..200	CDD:99898
Msh6	XP_038968982.1	MutS	416..1344	CDD:223327	459/968 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352976
Domainoid	1	1.000	258	1.000	Domainoid score	I1940
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	880	1.000	Inparanoid score	I386
OMA	1	1.010	-	-		QHG53698
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto98225
orthoMCL	1	0.900	-	-		OOG6_100652
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910