Protein Alignment Msh6 and msh6

DIOPT Version :9

• Sequence 1: NP_648755.1
• Gene: Msh6 / 39654
• FlyBaseID: FBgn0036486
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_002935421.3
• Gene: msh6 / 100145639
• XenbaseID: XB-GENE-986638
• Length: 1338
• Species: Xenopus tropicalis
• Alignment Length: 1230
• Identity: 520/1230 - (42%)
• Similarity: 753/1230 - (61%)
• Gaps: 105/1230 - (8%)

  Fly    20 YFSKSP-------------AFDK-KKLTPSVKTDPDASKSEKENLQNQQPKVKDGKKEASKPAA- 69
            :||..|             |.|| |:|..:|..:|..|:.:.|        ::|....||...|
 Frog   151 FFSTKPEIRKAIKMADDAMAQDKQKRLELAVCMEPSDSEEDME--------LEDEGSSASHDEAE 207

  Fly    70 --KRKLPISDDEPASGQRKRKRIVQPESDSEPEMEVTKSEDDFSDCASDYEPDENEASDDSVSSG 132
              |::.|:.:.: .:|:.||:||. .||||:.|    .|:|:|.        .|:.||.|..|||
 Frog   208 DVKKRQPVRESK-KNGKPKRRRIT-IESDSDNE----GSDDEFK--------PEDSASSDEASSG 258

  Fly   133 AEEVSPSENDMSVDSPTPKKSRKKSKILNNNNNNEPSSKKVKLE----STIQLAEGATFQEKLKN 193
            .:|...||.|...:..:|.|...|.|   ..|.::|:..|.:|:    .|.:.|...:.:.|||.
 Frog   259 VDEAKLSEPDSETEEDSPVKVPLKRK---RGNPDKPTGPKKRLQDELSETPKRASNVSAEAKLKL 320

  Fly   194 LQSNAKQDASYDDIVTNTSNLDEPVVWPHQKLEFLQPDKIKDKEGRRPDHPDYDKSTLHVPEKFL 258
            ...:|.:  |::. .||........||.|:|.::||..:.||.:.::.:..|||.|||:||:.||
 Frog   321 SSFSAPE--SFES-QTNAGGTGSVSVWDHEKFDWLQDGRRKDLKRKKQNDADYDPSTLYVPDDFL 382

  Fly   259 NGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHMDADVGVNELGFTYMRGEFAHSGFPEISFDK 323
            |..:||:|:||.|||.|:|.|:|:|||||||||||||.:||||||.|:|:|.:||||||||:|.:
 Frog   383 NKCTPGMRKWWQLKSQNFDTVIFYKVGKFYELYHMDAVIGVNELGLTFMKGAWAHSGFPEIAFGR 447

  Fly   324 MSTILVDRGFKVARVEQTETPDMMTERCKRIK-ATKFDKVVAREICQITNRGTQVFGSQCKIGPN 387
            .|.:||.:|:|||||||||||:||..|||.:. .:|||:||.||||:|..:|||.:.........
 Frog   448 FSDVLVQKGYKVARVEQTETPEMMEVRCKSMSHPSKFDRVVRREICRIITKGTQTYSVLDGNPSE 512

  Fly   388 HQPNYMLAIVEK-DEGTCSR--YGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEK 449
            ....|:|...|| |:.:..|  |||.|:|||:|.||:|:||||::|||..|||:|..|:..|.||
 Frog   513 SHSKYLLCFKEKMDDSSGQRRIYGVSFVDTSVGKFHVGQFEDDRHCSRFRTLVAHFPPIQILFEK 577

  Fly   450 SALSQRTQQIVRTVLGGILKEPVPGNGKHACSAEKTLKLLAERYY----AGPGSDDNWPLVLRTM 510
            ...|..|::::::.|...::|.:....:. ..|.||||.|||..|    ..||| .|.|.||:.:
 Frog   578 GNPSSDTKKVLKSCLSTSIQESLQPTSQF-WDAFKTLKTLAEEAYFEKDFQPGS-GNLPTVLKNL 640

  Fly   511 QSDMDHLGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLR 575
            .|:.|.|.|||.:..:|||.|||.||:::.||.::.::|.||.::.|:|.|...:...|.:|...
 Frog   641 TSENDSLALTPGEKSELALSALGACIYYLKKCLIDQELLSMANFEEYIPVDTGIEKAQASSSFFA 705

  Fly   576 RS--HMVLDATTLSNLRII------GEEHSLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKERQ 632
            ::  .||||..||:||.|:      ..|.:||..||.|.|.||||||..|||||.|:...|.:|.
 Frog   706 KTSQRMVLDGVTLTNLEILQNGTNGSTEGTLLEKLDTCSTPFGKRLLKQWLCAPLCNPFSINDRL 770

  Fly   633 DAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKLYNKQKLQ 697
            :|:.:|:.:|.::.||..||..:||.||.|::||..|: .:|..:||||||:::||..|:|:|:.
 Frog   771 NAVEDLMDLPDKVSEVSDLLKKLPDLERLLSKIHSIGS-PLKSQNHPDSRAVMYEEIAYSKKKIA 834

  Fly   698 GFMAVLKGFNDLTKLPTMFHQC----KTTLLKRITQL----PESGGSFPDLSKELQYFATAFDHD 754
            .|::.|:||..:.::.::....    |:::||:|..:    |:  |.|||||.||:.:.|:|||:
 Frog   835 DFLSALEGFKVMREVISILEDAAANFKSSILKQIVSIKGKTPQ--GHFPDLSAELKRWDTSFDHE 897

  Fly   755 AAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHFGCR-ITYFGSDKKRYQLDVPES 818
            .|.|||||.|:.|.|.:||.|:..|...|:.|..||.:|.:...|: :.|:|:.|.|||:::|||
 Frog   898 KARKTGVITPKVGFDPDYDEALKDIKTTEQDLNEYLDKQRKRLSCKTVVYWGTAKNRYQMEIPES 962

  Fly   819 HASKAN--KSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLKDLARRLFEKFSNHYD 881
             .::.|  :.|.|:...||.|   ||.|.....:..|:.:||:.|:..|||..||||..|..:|.
 Frog   963 -VTERNLPEEYELKSTKKGYK---RYWTKAIEKMFGDLANAEERRDAALKDCMRRLFYNFDKNYK 1023

  Fly   882 QWKQCIDCVANLDVLGSLAEYA-GQQMVICVPELV-SDADQPFIQLEEGYHPCAN----ASTYIP 940
            :|:..::|.|.||||.||::|: |....:|.|.:| .|...||::|:...|||..    ...:||
 Frog  1024 EWQTAVECFAVLDVLISLSQYSQGGDGPVCRPVIVLQDNHLPFLELKGSRHPCITKTFFGDDFIP 1088

  Fly   941 NGLELG--------TASEAPLSLLTGPNMGGKSTLMREVGLLVIMAQIGAHIPAASCRLSLVDRI 997
            |.:.:|        ::.||...|:|||||||||||:|:.||.|:|||:|.::||.||||:.|||:
 Frog  1089 NDILIGCKEEDSDDSSDEAHCVLVTGPNMGGKSTLLRQAGLQVVMAQLGCYVPAESCRLTPVDRV 1153

  Fly   998 FTRLGAQDDILAGHSTFLVELNETSLILKHATCHSLVLLDELGRGTATYDGTAIAASVVNFLA-N 1061
            ||||||.|.|:||.|||.|||:|||.||:|||.|||||||||||||||:||||||::||..|: :
 Frog  1154 FTRLGASDRIMAGESTFFVELSETSSILQHATEHSLVLLDELGRGTATFDGTAIASAVVKELSQS 1218

  Fly  1062 LKCRTLFSTHYHNLIDFFHNDKRITLGHMACMVENEDNADPTQETVTFLYKYTAGACPKSYGFNA 1126
            :|||||||||||:|::.:.:.:.:.|||||||||||.. ||:|||:|||||:..|||||||||||
 Frog  1219 VKCRTLFSTHYHSLVEDYSHSQAVRLGHMACMVENECE-DPSQETITFLYKFIKGACPKSYGFNA 1282

  Fly  1127 AKLAGMPQGIIKRAYELSKKVEAIALQRKITAKIVAATAGNEDTKKEKINALKDLLKQLK 1186
            |:||.:|..||:..::.:::.|:|.:..::..::....    |........|.:|||.|:
 Frog  1283 ARLAHIPDEIIQVGHQKAREFESITVSLRLFRELNLLL----DNPSSDGQVLHNLLKVLQ 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msh6	NP_648755.1	MttA_Hcf106	<44..156	CDD:294511	33/114 (29%)
		MutS	261..1186	CDD:223327	441/966 (46%)
		MutS_I	263..375	CDD:279898	73/112 (65%)
		MutS_II	391..508	CDD:282973	51/123 (41%)
		MutS_III	584..>667	CDD:282977	39/88 (44%)
		MutS_IV	767..859	CDD:282975	32/94 (34%)
		ABC_MSH6_euk	924..1140	CDD:213253	137/228 (60%)
msh6	XP_002935421.3	MSH6_like	74..181	CDD:99898	8/29 (28%)
		MSCRAMM_ClfB	<165..314	CDD:411414	49/173 (28%)
		MutS	386..1304	CDD:223327	434/927 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1943
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H149
Inparanoid	1	1.050	880	1.000	Inparanoid score	I397
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122599at33208
OrthoFinder	1	1.000	-	-		FOG0004305
OrthoInspector	1	1.000	-	-		oto104911
Panther	1	1.100	-	-	LDO	PTHR11361
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3037
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160