DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FucTA and FUT6

DIOPT Version :9

Sequence 1:	NP_001261872.1	Gene:	FucTA / 39653	FlyBaseID:	FBgn0036485	Length:	503	Species:	Drosophila melanogaster
Sequence 2:	NP_000141.1	Gene:	FUT6 / 2528	HGNCID:	4017	Length:	359	Species:	Homo sapiens

Alignment Length:	285	Identity:	104/285 - (36%)
Similarity:	141/285 - (49%)	Gaps:	34/285 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 CELTANRDLASTADMILYKDH---YIPTG--IRRPSNSKQVSMLYYLECPYHTQNVKVPDA-INW 263
            |.:||:|.:...||.::....   |.|:.  .|.|....|..:.:.:|.|.|...:|..|. .|.
Human    90 CNITADRKVYPQADAVIVHHREVMYNPSAQLPRSPRRQGQRWIWFSMESPSHCWQLKAMDGYFNL 154

  Fly   264 TATYRRDSTIVAPY---EKWQYYDTKVQQQEQDINYSVNKTKKVAWFVSNCGARNGRLQYAHELQ 325
            |.:||.||.|..||   |.|     ..|.....:|.|. ||:.|||.|||.|..:.|::|...||
Human   155 TMSYRSDSDIFTPYGWLEPW-----SGQPAHPPLNLSA-KTELVAWAVSNWGPNSARVRYYQSLQ 213

  Fly   326 KYIEVDIYGACGNFKCSRS----TADKCFEILDNDYKFYLAFENSNCKDYITEKFFVNALNRRVL 386
            .:::||:||        ||    ......|.|.. ||||||||||...||||||.:.|||....:
Human   214 AHLKVDVYG--------RSHKPLPQGTMMETLSR-YKFYLAFENSLHPDYITEKLWRNALEAWAV 269

  Fly   387 PIVMGARPEDYEVSAPRRSYIHVDEFSSPKELAEYLRILDHDDELYNSYFKWKGT---GEFINTY 448
            |:|:|....:||...|..::||||:|.|||:||.||:.||.|...|.|||:|:.|   ..|....
Human   270 PVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWAL 334

  Fly   449 YWCRVCATLHNEEQLRK---PRWYT 470
            .:|:.|..|..|.:.:.   ..|:|
Human   335 AFCKACWKLQEESRYQTRGIAAWFT 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FucTA	NP_001261872.1	Glyco_tran_10_N	173..277	CDD:293644	23/77 (30%)
FucTA	NP_001261872.1	Glyco_transf_10	300..473	CDD:279224	74/181 (41%)
FUT6	NP_000141.1	Glyco_tran_10_N	62..169	CDD:407214	24/78 (31%)
		determines site-specific fucosylation. /evidence=ECO:0000269\|PubMed:17604274	73..112		6/21 (29%)
		Glyco_transf_10	188..351	CDD:395683	72/171 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5576
eggNOG	1	0.900	-	-		E1_KOG2619
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34780
Inparanoid	1	1.050	148	1.000	Inparanoid score	I4402
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394490at33208
OrthoFinder	1	1.000	-	-		FOG0000215
OrthoInspector	1	1.000	-	-		mtm8516
orthoMCL	1	0.900	-	-		OOG6_100170
Panther	1	1.100	-	-	O	PTHR11929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.870