DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex3 and PEX3

DIOPT Version :9

Sequence 1:	NP_001261871.1	Gene:	Pex3 / 39652	FlyBaseID:	FBgn0036484	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_003621.1	Gene:	PEX3 / 8504	HGNCID:	8858	Length:	373	Species:	Homo sapiens

Alignment Length:	411	Identity:	138/411 - (33%)
Similarity:	212/411 - (51%)	Gaps:	71/411 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSRLQDFLSRHRRKFIVTGVLVGGTIFAARYAQRRFVEFQEKQAREFFERTRRTTHFESTEKTC 65
            ||..:.:||.||::|.|..|.::||.....:|.|::..|.||::|.|:..:.||..||||.::||
Human     1 MLRSVWNFLKRHKKKCIFLGTVLGGVYILGKYGQKKIREIQEREAAEYIAQARRQYHFESNQRTC 65

  Fly    66 NQVILGMGEEMCQAVLRECSTDELLEQLRQNPKNKLELWEDMKIVAFTRLATYVYASSMLVIALR 130
            |..:|.|...:.:|::::.:::.|...|:..|.||||:|||:||::|||....||::.|||:.||
Human    66 NMTVLSMLPTLREALMQQLNSESLTALLKNRPSNKLEIWEDLKIISFTRSTVAVYSTCMLVVLLR 130

  Fly   131 VQLNLLGGYIYRDIMTEQKQVT-----DELKQQYLSLIRHFITDSGIRDLARYIRTQVIAVTKTI 190
            ||||::|||||.|.....|..|     .:::|||||.|:|.:.| |:.:|...|:..|..|..::
Human   131 VQLNIIGGYIYLDNAAVGKNGTTILAPPDVQQQYLSSIQHLLGD-GLTELITVIKQAVQKVLGSV 194

  Fly   191 PLSEQLSLSDLEQLFWSLQMAINADTRRDPNSRMSK---------YLLPSQNPSHSPLLQ----- 241
            .|...|||.||||   .|:...|...:...:|.::|         |::|.:   .:||..
Human   195 SLKHSLSLLDLEQ---KLKEIRNLVEQHKSSSWINKDGSKPLLCHYMMPDE---ETPLAVQACGL 253

  Fly   242 --------KMVNETLDLLESEDAVGVCSHNVSRGFVLACDAIAESMGETLQHLPQAKVQTQQEQS 298
                    |::|||.|:|||.|...|.:..::|||....|.:||....|.|.|
Human   254 SPRDITTIKLLNETRDMLESPDFSTVLNTCLNRGFSRLLDNMAEFFRPTEQDL------------ 306

  Fly   299 VKFNQAGSLGASTSKSQNGLENNNLLNINRVLLALAKLIPIISGLTSRGFDTTSRPHNLPTQLLT 363
                            |:|   |::.:::.|.|.|||:|||::|........|  |.:....|||
Human   307 ----------------QHG---NSMNSLSSVSLPLAKIIPIVNGQIHSVCSET--PSHFVQDLLT 350

  Fly   364 FYVVAEKTKTLGANVYESFSS 384
            .    |:.|...|||||:||:
Human   351 M----EQVKDFAANVYEAFST 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex3	NP_001261871.1	Peroxin-3	11..268	CDD:282706	100/283 (35%)
PEX3	NP_003621.1	Targeting to peroxisomes. /evidence=ECO:0000269\|PubMed:11390669	1..45		16/43 (37%)
		Peroxin-3	11..362	CDD:309834	129/394 (33%)
		Interaction with PEX19. /evidence=ECO:0000269\|PubMed:11390669	120..136		10/15 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9395
eggNOG	1	0.900	-	-		E1_KOG4444
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2691
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3807
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56127
OrthoDB	1	1.010	-	-		D381303at33208
OrthoFinder	1	1.000	-	-		FOG0004280
OrthoInspector	1	1.000	-	-		oto89181
orthoMCL	1	0.900	-	-		OOG6_103586
Panther	1	1.100	-	-	LDO	PTHR28080
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3683
SonicParanoid	1	1.000	-	-		X4649
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870