DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDI1

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_009887.1	Gene:	PDI1 / 850314	SGDID:	S000000548	Length:	522	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	173/542 - (31%)
Similarity:	270/542 - (49%)	Gaps:	87/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKF-----LICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCK 60
            |||     |..:..|.||.|.|..||....:..|:....|:|.:.|..::.||.||:||||||||
Yeast     1 MKFSAGAVLSWSSLLLASSVFAQQEAVAPEDSAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCK 65

  Fly    61 ALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRS---GSPVEYSGGRQA 122
            .:||||.|||:.|.||.  |.||::|.|...:|..::.:.|:|:||.|::   .:.::|.|.|.|
Yeast    66 NMAPEYVKAAETLVEKN--ITLAQIDCTENQDLCMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTA 128

  Fly   123 ADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIA--IIGFFKDLESEEAKTFTKVANA-LDSFVF 184
            ..|:.::.|::.|.   :..|||...:|.:....  :|.....::::...||..:||. .:.:.|
Yeast   129 EAIVQFMIKQSQPA---VAVVADLPAYLANETFVTPVIVQSGKIDADFNATFYSMANKHFNDYDF 190

  Fly   185 GVSSNADVIAKY-----EAKDNGVVLFKPFDDKKS------VFEGELNEENLKKFAQVQSLPLIV 238
            ..:.|||...|.     .|.|..||    ::.||:      |||         |:.||::||
Yeast   191 VSAENADDDFKLSIYLPSAMDEPVV----YNGKKADIADADVFE---------KWLQVEALP--- 239

  Fly   239 DFNHESASKIFGGSIKSHL----LFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHT 299
             :..|....:|...::|.|    ||:...|  .:|:|.....|:|||.|..:.||:|.:.:
Yeast   240 -YFGEIDGSVFAQYVESGLPLGYLFYNDEE--ELEEYKPLFTELAKKNRGLMNFVSIDARK---- 297

  Fly   300 RIFEFFGMN------KEEVPTIRLIKLEEDMAKYKPE-----SDDLS------AETIEAFLKKFL 347
                 ||.:      ||:.|...:..:.||:....|:     .|:||      ::.||:.:|.||
Yeast   298 -----FGRHAGNLNMKEQFPLFAIHDMTEDLKYGLPQLSEEAFDELSDKIVLESKAIESLVKDFL 357

  Fly   348 DGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAE 412
            .|.....:.|||:.|:.|.: |..||..|.:.:..|..|.|||.:|||||||||:|||.|.:||:
Yeast   358 KGDASPIVKSQEIFENQDSS-VFQLVGKNHDEIVNDPKKDVLVLYYAPWCGHCKRLAPTYQELAD 421

  Fly   413 KYKD-NEDIVIAKMDSTANELESIKISSFPTIKYF--RKEDNKVIDFNLDRTLD---DFVK---F 468
            .|.: ..|::|||:|.|.|::..:.|..:|||..:  .|:...|: :...|:||   ||:|   .
Yeast   422 TYANATSDVLIAKLDHTENDVRGVVIEGYPTIVLYPGGKKSESVV-YQGSRSLDSLFDFIKENGH 485

  Fly   469 LDANGEVADSEPVEETEEEEEA 490
            .|.:|:....|..|:..||.:|
Yeast   486 FDVDGKALYEEAQEKAAEEADA 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	156/493 (32%)
		pdi_dom	33..133	CDD:273454	42/102 (41%)
		PDI_b_family	137..231	CDD:239279	24/107 (22%)
		PDI_b'_family	244..347	CDD:239280	30/123 (24%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	44/109 (40%)
PDI1	NP_009887.1	ER_PDI_fam	32..492	CDD:273457	157/494 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I1819
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55495
Inparanoid	1	1.050	213	1.000	Inparanoid score	I801
Isobase	1	0.950	-	0	Normalized mean entropy	S1096
OMA	1	1.010	-	-		QHG53639
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		mtm9187
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
TreeFam	1	0.960	-	-
	13	12.710