DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDIL1-2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_177875.1	Gene:	PDIL1-2 / 844087	AraportID:	AT1G77510	Length:	508	Species:	Arabidopsis thaliana

Alignment Length:	517	Identity:	180/517 - (34%)
Similarity:	290/517 - (56%)	Gaps:	37/517 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYA 67
            |...::.|..|...:|..:| :.:|.||.....||.:.|:.::|::|||||||||||:.|||||.
plant     6 FACFSILLLLSLFVSSIRSE-ETKEFVLTLDHSNFTETISKHDFIVVEFYAPWCGHCQKLAPEYE 69

  Fly    68 KAAQQLAEKESPIKLAKVDATVEG--ELAEQYAVRGYPTLKFFRSG--SPVEYSGGRQAADIIAW 128
            |||.:|:....|:.|||:||:.|.  |.|.:|.::|:||||..|:|  |..:|:|.|:|..|:.:
plant    70 KAASELSSHNPPLALAKIDASEEANKEFANEYKIQGFPTLKILRNGGKSVQDYNGPREAEGIVTY 134

  Fly   129 VTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDS-FVFGVSSNADV 192
            :.|::||.:.::.|...|.:.:.:..:..:|.|..|..:|..:|..:|..|.: :.|..:.:|..
plant   135 LKKQSGPASVEIKSADSATEVVGEKNVVAVGVFPKLSGDEFDSFMALAEKLRADYDFAHTLDAKF 199

  Fly   193 IAKYEAKDNGVV-LFKPFD----DKKSVFEGELNEENLKKFAQVQSLPLIVDF-----NHESASK 247
            :.:.|:.:...| ||||||    |.|     :.|.|.|:||.:..|:||:..|     ||...:|
plant   200 LPRGESVEGPAVRLFKPFDELFVDSK-----DFNGEALEKFVKESSIPLVTVFDSDPNNHPYVAK 259

  Fly   248 IFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEV 312
            .| .|..:..:.||:..|...|......:|:|...:|..|...: .|.|.....|::||:.:.:|
plant   260 FF-ESPATKAMMFVNFTGATAEALKSKYREVATSNKDQSLAFLV-GDAESSQGAFQYFGLEESQV 322

  Fly   313 PTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNF 377
            |.|  |....|..||.  ..::..:.||::.|.|.|||:..|..||.:|.: :..||||:|:.:.
plant   323 PLI--IIQTPDNKKYL--KVNVEVDQIESWFKDFQDGKVAVHKKSQPIPAE-NNEPVKVVVAESL 382

  Fly   378 ESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANEL--ESIKISSF 440
            :.:.....|:||:||||||||||::||||.|::|..::::..::|||:|:|||::  ::..:..|
plant   383 DDIVFKSGKNVLIEFYAPWCGHCQKLAPILDEVALSFQNDPSVIIAKLDATANDIPSDTFDVKGF 447

  Fly   441 PTIKYFRKEDNKVIDFNLDRTLDDFVKFLDANGEV------ADSEPVEETEEEEEAPKKDEL 496
            ||| |||.....|:.:..|||.:||:.|::.|.|.      .:|...||.::.||...||||
plant   448 PTI-YFRSASGNVVVYEGDRTKEDFINFVEKNSEKKPTSHGEESTKSEEPKKTEETAAKDEL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	165/463 (36%)
		pdi_dom	33..133	CDD:273454	48/103 (47%)
		PDI_b_family	137..231	CDD:239279	26/99 (26%)
		PDI_b'_family	244..347	CDD:239280	26/102 (25%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	44/102 (43%)
PDIL1-2	NP_177875.1	ER_PDI_fam	29..481	CDD:273457	165/464 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I719
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.780