DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and PDIL1-5

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_175636.2	Gene:	PDIL1-5 / 841656	AraportID:	AT1G52260	Length:	537	Species:	Arabidopsis thaliana

Alignment Length:	492	Identity:	142/492 - (28%)
Similarity:	247/492 - (50%)	Gaps:	33/492 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIK 81
            :.||...|.:..||....|..|::|..||||:|..|||||.....|.|.:|:||..|.|..|.:.
plant    67 SEAETVSKAQRIVLELNGDYTKRVIDGNEFVMVLGYAPWCARSAELMPRFAEAATALKEIGSSVL 131

  Fly    82 LAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADA 146
            :||:|.....::|.:..::|:|||..|.:|:.:.|:||..|.||:.||.||||.|...|.:|.:|
plant   132 MAKIDGDRYSKIASELEIKGFPTLLLFVNGTSLTYNGGSSAEDIVIWVQKKTGAPIITLNTVDEA 196

  Fly   147 EQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKY---EAKDNGVV--LF 206
            .:||......::|.|:..|..|...|.|.|.:.|...|..:.::|| ||.   :.|.|.|.  |.
plant   197 PRFLDKYHTFVLGLFEKFEGSEHNEFVKAAKSDDEIQFIETRDSDV-AKLLFPDLKSNNVFIGLV 260

  Fly   207 KPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKY 271
            ||..::.:|::|....|.:.:|......||.......:...::...:|..::.|  .:....:|.
plant   261 KPEAERYTVYDGSYKMEKILEFLGSNKFPLFTKLTETNTVWVYSSPVKLQVMLF--SKADDFQKL 323

  Fly   272 VDPLKEIAKKYRDDILFVTISSDEEDHTRIF-EFFGM---NKEEVPTIRLIKLEEDM-AKYKPES 331
            ..||::||:|::..::|:.:....|:....| ..||:   ||..|..     .:.:: :||..||
plant   324 AQPLEDIARKFKSKLMFIYVDITNENLAMPFLILFGIEAGNKTVVAA-----FDNNLNSKYLLES 383

  Fly   332 DDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPW 396
            |. |..:||.|......|.:.::..|:.:|::.:.:.|.| |...|:.:.|:..::||:|.:.||
plant   384 DP-SPNSIEEFCSGLAHGTVSRYYRSEPVPDNENASIVTV-VGKTFDGLVLNSRENVLLEVHTPW 446

  Fly   397 CGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKI-SSFPTIKYFRK-EDNKVIDFNLD 459
            |.:|:.|:...::||:.:|..|::|.|::|::|||...::: ..:|.|..::. |..|.:..:..
plant   447 CVNCEALSKQIEKLAKHFKGFENLVFARIDASANEHTKLQVDDKYPIILLYKSGEKEKPLKLSTK 511

  Fly   460 RTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDEL 496
            .:..|...|::           ||..:.:....||||
plant   512 LSAKDIAVFIN-----------EELLKPKNGSAKDEL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	133/458 (29%)
		pdi_dom	33..133	CDD:273454	40/99 (40%)
		PDI_b_family	137..231	CDD:239279	28/98 (29%)
		PDI_b'_family	244..347	CDD:239280	25/107 (23%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	28/102 (27%)
PDIL1-5	NP_175636.2	ER_PDI_fam	79..524	CDD:273457	133/465 (29%)
		PDI_a_family	80..179	CDD:239259	38/98 (39%)
		PDI_b_family	187..286	CDD:239279	28/99 (28%)
		PDI_b'_family	303..394	CDD:239280	24/98 (24%)
		PDI_a_PDI_a'_C	418..521	CDD:239293	28/103 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3267
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890