DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDIL1-1

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_173594.1	Gene:	PDIL1-1 / 838779	AraportID:	AT1G21750	Length:	501	Species:	Arabidopsis thaliana

Alignment Length:	512	Identity:	196/512 - (38%)
Similarity:	293/512 - (57%)	Gaps:	37/512 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYA 67
            |.|..|.|.||.: .|.|.|.|  |.||.....||...|..::|::||||||||||||.|||||.
plant     9 FSILVLSLCASSI-RSEETETK--EFVLTLDHTNFTDTINKHDFIVVEFYAPWCGHCKQLAPEYE 70

  Fly    68 KAAQQLAEKESPIKLAKVDATVE--GELAEQYAVRGYPTLKFFRSGSPV--EYSGGRQAADIIAW 128
            |||..|:....|:.|||:||:.|  .|.|.||.|:|:||:|.||:|...  ||:|.|:|..|:.:
plant    71 KAASALSSNVPPVVLAKIDASEETNREFATQYEVQGFPTIKIFRNGGKAVQEYNGPREAEGIVTY 135

  Fly   129 VTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFV-FGVSSNADV 192
            :.|::||.:.::.|..||.:.:.|.::.::|.|..|...|..:|..:|..|.|.: |..:|:|.:
plant   136 LKKQSGPASAEIKSADDASEVVSDKKVVVVGIFPKLSGSEFDSFMAIAEKLRSELDFAHTSDAKL 200

  Fly   193 IAKYEAKDNGVV--LFKPFD----DKKSVFEGELNEENLKKFAQVQSLPLIVDF-----NHESAS 246
            :.:.|:...|.|  ||||||    |.|. |:||.    |:||.:..|:|||..|     ||....
plant   201 LPRGESSVTGPVVRLFKPFDEQFVDSKD-FDGEA----LEKFVKESSIPLITVFDKDPNNHPYVI 260

  Fly   247 KIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEE 311
            |.| .|..:..:.|::..|...|......:|:|...:...|...: .|.|:....|::||:.:.:
plant   261 KFF-ESTNTKAMLFINFTGEGAESLKSKYREVATSNKGQGLSFLL-GDAENSQGAFQYFGLEESQ 323

  Fly   312 VPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSN 376
            ||.| :|:..:|....|   .::..:.||:::|.|.|||:..|..||.:|.: :..||||:||.:
plant   324 VPLI-IIQTADDKKYLK---TNVEVDQIESWVKDFKDGKIAPHKKSQPIPAE-NNEPVKVVVSDS 383

  Fly   377 FESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANEL--ESIKISS 439
            .:.:.|:..|:||:||||||||||::||||.|::|..|:.:..:||||:|:|||:.  ::..:..
plant   384 LDDIVLNSGKNVLLEFYAPWCGHCQKLAPILDEVAVSYQSDSSVVIAKLDATANDFPKDTFDVKG 448

  Fly   440 FPTIKYFRKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDEL 496
            |||| ||:.....|:.:..|||.:||:.|:|.|.:.. .||.:|.|..||.  ||||
plant   449 FPTI-YFKSASGNVVVYEGDRTKEDFISFVDKNKDTV-GEPKKEEETTEEV--KDEL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	176/464 (38%)
		pdi_dom	33..133	CDD:273454	51/103 (50%)
		PDI_b_family	137..231	CDD:239279	32/100 (32%)
		PDI_b'_family	244..347	CDD:239280	23/102 (23%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	47/102 (46%)
PDIL1-1	NP_173594.1	ER_PDI_fam	30..481	CDD:273457	175/463 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I719
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.780