DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDIL1-4

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_851234.1	Gene:	PDIL1-4 / 836185	AraportID:	AT5G60640	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	503	Identity:	189/503 - (37%)
Similarity:	278/503 - (55%)	Gaps:	39/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVE 90
            |:.|:|....||..:|.:|::|||||||||||||::||||||.||.:|  ||..:.|||:|||.|
plant   102 EKDVVVIKERNFTDVIENNQYVLVEFYAPWCGHCQSLAPEYAAAATEL--KEDGVVLAKIDATEE 164

  Fly    91 GELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEI 155
            .|||::|.|:|:|||.||..|....|:|||....|:.||.||.||...:||::.|||:.|.....
plant   165 NELAQEYRVQGFPTLLFFVDGEHKPYTGGRTKETIVTWVKKKIGPGVYNLTTLDDAEKVLTSGNK 229

  Fly   156 AIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKY----EAKDNGVVLFKPFDDKKSVF 216
            .::|:...|...|.......:.|.|...|..:.|.||...:    |:|...:||.|..::|.|.|
plant   230 VVLGYLNSLVGVEHDQLNAASKAEDDVNFYQTVNPDVAKMFHLDPESKRPALVLVKKEEEKISHF 294

  Fly   217 EGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKK 281
            :||..:..|..|.....|.|:..|..|:|.:||..:||..||.||::  ...||.:...:|.||.
plant   295 DGEFVKSALVSFVSANKLALVSVFTRETAPEIFESAIKKQLLLFVTK--NESEKVLTEFQEAAKS 357

  Fly   282 YRDDILFVTISSDEEDHTR-IFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKK 345
            ::..::||::..|.||:.: :.|:||::... |.:......||..||..:. ::.::.|:.|.:.
plant   358 FKGKLIFVSVDLDNEDYGKPVAEYFGVSGNG-PKLIGYTGNEDPKKYFFDG-EIQSDKIKIFGED 420

  Fly   346 FLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQL 410
            ||:.|||....|..:||..|:: ||::|..||:.:.||.||.||:|.||||||||:.|.|:|::|
plant   421 FLNDKLKPFYKSDPIPEKNDED-VKIVVGDNFDEIVLDDSKDVLLEVYAPWCGHCQALEPMYNKL 484

  Fly   411 AEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF--RKEDNKVIDFNLDRTLDDFVKFLDANG 473
            |:..:..:.:||.|||.|.||....|...||||.:|  ..:.::.|..:.|||:..|.|||..:.
plant   485 AKHLRSIDSLVITKMDGTTNEHPKAKAEGFPTILFFPAGNKTSEPITVDTDRTVVAFYKFLRKHA 549

  Fly   474 EV---------------ADSEPVEETEEEEEAP----------KKDEL 496
            .:               |:|.|..||.|.:|:|          .||||
plant   550 TIPFKLEKPASTESPKTAESTPKVETTETKESPDSTTKSSQSDSKDEL 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	176/453 (39%)
		pdi_dom	33..133	CDD:273454	55/99 (56%)
		PDI_b_family	137..231	CDD:239279	27/97 (28%)
		PDI_b'_family	244..347	CDD:239280	29/103 (28%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	45/102 (44%)
PDIL1-4	NP_851234.1	ER_PDI_fam	103..557	CDD:273457	176/460 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I1934
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55495
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		otm3176
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790