DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDIL1-3

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_191056.2	Gene:	PDIL1-3 / 824661	AraportID:	AT3G54960	Length:	579	Species:	Arabidopsis thaliana

Alignment Length:	491	Identity:	174/491 - (35%)
Similarity:	266/491 - (54%)	Gaps:	29/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 EEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVE 90
            |:.|.|.|.|||.:.:.:|.|.:|||||||||.|:||.||||.||.:|   :....|||:|||.|
plant    98 EKDVAVLTKDNFTEFVGNNSFAMVEFYAPWCGACQALTPEYAAAATEL---KGLAALAKIDATEE 159

  Fly    91 GELAEQYAVRGYPTLKFFRSGSPVE-YSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNE 154
            |:||::|.::|:||:..|..|...: |.|.|....|:.|:.||..|...::|:..:||:.|....
plant   160 GDLAQKYEIQGFPTVFLFVDGEMRKTYEGERTKDGIVTWLKKKASPSIHNITTKEEAERVLSAEP 224

  Fly   155 IAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKYE----AKDNGVVLFKPFDDKKSV 215
            ..:.||...|...|::.....:...|...|..:::.|:...:|    .|...:||.|..::|.:.
plant   225 KLVFGFLNSLVGSESEELAAASRLEDDLSFYQTASPDIAKLFEIETQVKRPALVLLKKEEEKLAR 289

  Fly   216 FEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAK 280
            |:|...:..:.:|.....:||:::|..|.||.||..|:|:.|:.|.  :....||::..|:|:||
plant   290 FDGNFTKTAIAEFVSANKVPLVINFTREGASLIFESSVKNQLILFA--KANESEKHLPTLREVAK 352

  Fly   281 KYRDDILFVTISSDEEDH-TRIFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLK 344
            .::...:||.:..|.||: ..:..|||:. ...|.:.:....|||.|:..:. :|:...|:...:
plant   353 SFKGKFVFVYVQMDNEDYGEAVSGFFGVT-GAAPKVLVYTGNEDMRKFILDG-ELTVNNIKTLAE 415

  Fly   345 KFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQ 409
            .||..|||....|..|||:.| ..|||:|.:||:.:.||:||.||:|.||||||||:...|||::
plant   416 DFLADKLKPFYKSDPLPENND-GDVKVIVGNNFDEIVLDESKDVLLEIYAPWCGHCQSFEPIYNK 479

  Fly   410 LAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDNKVID---FNLDRTLDDFVKFLDA 471
            |.:..|..:.:|:||||.|:||....|...||||.:| ...||..|   .::|||:.:..|||..
plant   480 LGKYLKGIDSLVVAKMDGTSNEHPRAKADGFPTILFF-PGGNKSFDPIAVDVDRTVVELYKFLKK 543

  Fly   472 NGEV-------ADSEPVEETEEEEEA----PKKDEL 496
            :..:       |..|||..|.:.:|.    ..||||
plant   544 HASIPFKLEKPATPEPVISTMKSDEKIEGDSSKDEL 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	163/455 (36%)
		pdi_dom	33..133	CDD:273454	47/100 (47%)
		PDI_b_family	137..231	CDD:239279	20/97 (21%)
		PDI_b'_family	244..347	CDD:239280	29/103 (28%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	47/103 (46%)
PDIL1-3	NP_191056.2	ER_PDI_fam	99..553	CDD:273457	163/462 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I1934
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55495
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		otm3176
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790