DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Pdilt

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_082219.1	Gene:	Pdilt / 71830	MGIID:	1919080	Length:	588	Species:	Mus musculus

Alignment Length:	511	Identity:	143/511 - (27%)
Similarity:	262/511 - (51%)	Gaps:	24/511 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFLICALFLAA---SYVAASAEAEVKV----------EEGVLVATVDNFKQLIADNEFVLVEFY 52
            |:.|...|.|.|   |.|..|.|.:..:          :..::|.|.....|.:.:..|::|.|:
Mouse     1 MELLWTPLLLVAACLSEVLGSPEIDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFH 65

  Fly    53 APWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGS---PV 114
            .|.....:.||.|..|||:...:.::.:...|||.|.|.||.:::.:...|.||.|..|:   |:
Mouse    66 NPSLKQSRKLAKELGKAAEIFGKGKNGLGFGKVDITKETELQQEFDITHAPELKLFFEGNRLKPI 130

  Fly   115 EYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANAL 179
            ......::..::.|:.::....|....:..:...|:|...:.|:|||:|||.|.|:.|.......
Mouse   131 SCKDVVESTALVVWLRRQISKKALLFNNSDEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDF 195

  Fly   180 DSFVFGVSSNADVIAKYEAKDNGVVLFK--PFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNH 242
            ....||.....:...::....:.|::||  ....::.:.....|:::|.:..:.|....:::.|.
Mouse   196 PELTFGAIQIKNSFGRFHVILDSVLVFKKGKIVKRQELINDSTNKDHLNQVIKQQLTGFVIELNP 260

  Fly   243 ESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGM 307
            |:...|:..:|.:|:|.|:|:............::|||::::.||||.:::||..:.||||:|.:
Mouse   261 ENKDLIYELNILNHMLLFISKSSEPYSTISRHYRQIAKEFQNKILFVLVNADEPKNKRIFEYFQI 325

  Fly   308 NKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVL 372
            ::..||:::::.|..| .:||..:||::.|:::.|...||....|:|..|:|:|:.||:.|||.|
Mouse   326 SRVNVPSVQILNLSSD-GRYKMPTDDINFESLKKFCNSFLSKTAKKHKASEEIPKYWDQGPVKKL 389

  Fly   373 VSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKI 437
            |..||..|.|||.|.|.|.|||||...|:.|.|:.::|..||:::..::|||:|.|||:::....
Mouse   390 VGKNFNVVVLDKEKDVFVMFYAPWSEKCRVLLPLLEELGIKYQNHSTVIIAKIDITANDIQLANP 454

  Fly   438 SSFPTIKYFRKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEP-----VEETEEEE 488
            ..:|..:.|..:..:.:.:..:.|:..|..||:::.:|...|.     :|:.||||
Mouse   455 EQYPFFRLFPTDSQEAVMYKGEHTMKGFCDFLESHVKVRIEEEDELLYIEQNEEEE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	127/451 (28%)
		pdi_dom	33..133	CDD:273454	26/102 (25%)
		PDI_b_family	137..231	CDD:239279	20/95 (21%)
		PDI_b'_family	244..347	CDD:239280	30/102 (29%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	36/100 (36%)
Pdilt	NP_082219.1	ER_PDI_fam	44..498	CDD:273457	129/454 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..588
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	585..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810