DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Erp27

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_081259.1	Gene:	Erp27 / 69187	MGIID:	1916437	Length:	272	Species:	Mus musculus

Alignment Length:	312	Identity:	69/312 - (22%)
Similarity:	131/312 - (41%)	Gaps:	69/312 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRS 110
            ||||      ||....:..:..:|...|:..:.||.|..|.||||
Mouse    13 FVLV------CGLVPEVTADVEEATDGLSTTQEPIWLTDVPATVE-------------------- 51

  Fly   111 GSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKV 175
                                         |.:.|         |:|:||||:|||......|..:
Mouse    52 -----------------------------LIAAA---------EVAVIGFFQDLEIPIVSVFRSM 78

  Fly   176 ANALDSFVFGVSSNADVIAKYEAKDNGVVLFKPFDDKKSVFEGE----LNEENLKKFAQVQSLPL 236
            |.......||:|::::|:..|....|.:.||:..||::.....|    |:...|.:|..|.:|..
Mouse    79 ARQFQDVSFGISNHSEVLTHYNVTSNSICLFRLVDDQQLHLNAEDIENLDAAKLSRFIHVNNLHW 143

  Fly   237 IVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRI 301
            :.:::...|:.:|...:::|||..:.:.....|:.:...:|.||.::..||||.:.|.:.::.::
Mouse   144 VTEYSPMIAAGLFNTMVQTHLLLMMKKTSPEYEESMRRYREAAKLFQGQILFVLVDSGKRENGKV 208

  Fly   302 FEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQ 353
            ..:|.:.:.::|.:.:.:..:|.....|.: :::.|.:..|.:.||.|.|::
Mouse   209 MSYFKLKESQLPALAIYESVDDKWDTLPIA-EVTVEKVRGFCEGFLKGLLQR 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	69/312 (22%)
		pdi_dom	33..133	CDD:273454	16/86 (19%)
		PDI_b_family	137..231	CDD:239279	27/97 (28%)
		PDI_b'_family	244..347	CDD:239280	20/102 (20%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
Erp27	NP_081259.1	Thioredoxin_6	64..250	CDD:372755	42/186 (23%)
		PDIA3-binding site. /evidence=ECO:0000250\|UniProtKB:Q96DN0	230..233		1/2 (50%)
		Prevents secretion from ER. /evidence=ECO:0000250\|UniProtKB:Q96DN0	269..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.910