Protein Alignment Pdi and Erp27

DIOPT Version :10

• Sequence 1: NP_524079.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_081259.1
• Gene: Erp27 / 69187
• MGIID: 1916437
• Length: 272
• Species: Mus musculus
• Alignment Length: 310
• Identity: 69/310 - (22%)
• Similarity: 99/310 - (31%)
• Gaps: 85/310 - (27%)

  Fly   280 IVPDLG--KRDIYMAYLPLAHILELAAESVMATIGSAIGYGSPLTLTDTSNKIK--KGTKGDVTA 340
            ::.||.  |:..|...|.|..:.|.....:..|:.|.|    ||. .|...:::  :|.:..|..
Mouse   150 LIEDLSLVKKVYYEPMLKLDIMTESELGQIFGTLDSLI----PLH-EDLLVRLEGLRGAEKTVQE 209

  Fly   341 LKPTIMTAVPAILDRVRDGVRKKVDAKGGLSKKLFDFAYARRLSAINGSWFGAWGLEKL-LWDVL 404
            :.||:|...|. |:........:|.||..|.:|..|....:.|.....|.|.    .|| ||:.|
Mouse   210 VGPTMMDWFPC-LEAYITYCCNQVGAKALLDQKKQDKRVEQFLRLCQESSFS----RKLDLWNFL 269

  Fly   405 VFRKIRAVLGGQIRYLLSGGAPLSGD-----------TQRFI---NICVGAPIGQGY--GLTET- 452
            ...:.|.|....:...:....||...           .||.|   |:..|....|.|  ||...
Mouse   270 DLPRSRLVKYPLLLKEIQKSTPLDHPDEDALPQAMELIQRIITEVNLKTGEAECQFYRRGLCYAE 334

  Fly   453 ---------------CAGGTFSE---------FE-------DTSVGRVG--------APLPCSFV 478
                           |.|...|.         ||       ..:..|.|        .|:|.:.:
Mouse   335 DSQRVAEIQASRFLYCHGELKSTKGQKLHVFLFELVLVLTRPVAQDREGPVQFQVYRQPMPAAHL 399

  Fly   479 KLVDWAEGGYLTSDKPMPRGEIVIGGSNITLGYFKNEEKTKEVYKVDEKG 528
            .|.|            :|.||....||  ..|.|...:|.|..::|...|
Mouse   400 HLED------------LPDGEPSSSGS--FRGAFTGNDKVKNCFRVSTTG 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_524079.1	ER_PDI_fam	27..474	CDD:273457	55/254 (22%)
Erp27	NP_081259.1	Thioredoxin_6	64..250	CDD:463999	26/105 (25%)
		PDIA3-binding site. /evidence=ECO:0000250|UniProtKB:Q96DN0	230..233		0/2 (0%)
		Prevents secretion from ER. /evidence=ECO:0000250|UniProtKB:Q96DN0	269..272		1/2 (50%)