DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Tmx3

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_938037.2	Gene:	Tmx3 / 67988	MGIID:	2442418	Length:	456	Species:	Mus musculus

Alignment Length:	364	Identity:	89/364 - (24%)
Similarity:	156/364 - (42%)	Gaps:	71/364 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AEVKVEEGVLVATVDNFKQLIADN---EFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKL 82
            |.:.::..|....|::..:...||   :..||:||||||||||.|.|.:.:...::....||:|:
Mouse    18 AVILLDLAVCKGFVEDLNESFKDNRKDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKV 82

  Fly    83 AKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAE 147
            .|:|||....:|.::.||||||:|..:......|.|.|...|||.:..:.:|...:.|.|....:
Mouse    83 GKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFD 147

  Fly   148 QFLKDNEIAIIGFFKDL--ESEEAKTFTKVANALDSFVFGVSSNADVIAKYEAKDN--GVVLFKP 208
            ...|.:.:    ||..:  ||...:.:...|:.|..:.:..|::.||:.:|.....  .|::||
Mouse   148 HVRKRHRV----FFVYIGGESPLKEKYIDAASELIVYTYFFSASEDVVPEYVTLKEMPAVLVFK- 207

  Fly   209 FDDKKSVF----EGEL----NEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREG 265
             ||...|:    :|:|    :.|..:.:..:....|     :|     .|.:.|...:..:..:.
Mouse   208 -DDTYFVYDEYEDGDLSSWISRERFQNYLTMDGFLL-----YE-----LGDTGKLVAIAVIDEKN 261

  Fly   266 GHIE--KYVDPLKEIAKKYRD----DILFVTISSDEEDHTRIFEFFGMNKEEVPTI--------- 315
            ..:|  :....::|:|:.:||    |..|..:..::..:|.:     |::..||||
Mouse   262 TSLEHTRLKSIIQEVARDFRDHFHRDFQFGHMDGNDYINTLL-----MDELTVPTIVVLNTSNQQ 321

  Fly   316 -----RLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDG 349
                 |.||...||.:               |:...|||
Mouse   322 YFLLDRHIKDASDMVQ---------------FINSILDG 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	88/358 (25%)
		pdi_dom	33..133	CDD:273454	38/102 (37%)
		PDI_b_family	137..231	CDD:239279	22/105 (21%)
		PDI_b'_family	244..347	CDD:239280	21/122 (17%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
Tmx3	NP_938037.2	PDI_a_TMX3	30..133	CDD:239298	38/102 (37%)
		Thioredoxin_6	163..340	CDD:290560	40/208 (19%)
		Thioredoxin_like	260..343	CDD:294274	19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..456
		Di-lysine motif	453..456
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846770
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840