DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and zgc:136472

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001035331.1	Gene:	zgc:136472 / 678514	ZFINID:	ZDB-GENE-060421-2552	Length:	510	Species:	Danio rerio

Alignment Length:	507	Identity:	162/507 - (31%)
Similarity:	283/507 - (55%)	Gaps:	14/507 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPE 65
            ::.::| |||..: :|.|....:..::.|||.|..||.:.:..:|.:||.||||..|.......|
Zfish     7 LRLIVC-LFLHQT-LAESQSNSIVEDKDVLVLTKSNFHRALKQHEQLLVHFYAPLSGQSLGSILE 69

  Fly    66 YAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG---SPVEYSGGRQAADIIA 127
            :.:||..|.|.:|.:||..||...|.||||...:...|:::.:.||   :||.....:.:|.|:.
Zfish    70 FREAAGALKEADSDVKLGGVDVKKEKELAESLNITTLPSIRLYLSGDKNNPVYCPVLKSSASILT 134

  Fly   128 WVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADV 192
            |:.::.||.|..:::|...|.||:.:|:.::..|||||....|.|.:.|..:....|||:.:.:|
Zfish   135 WLKRRAGPSADIISNVTQLENFLRRDELVVLALFKDLEEGAVKVFYETAADVADLPFGVTRHHEV 199

  Fly   193 IAKYE-AKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
            .:|:| ::|:.:::.|...|::...|....:.:|..|.::..:.|:.::|..:||||....|.:|
Zfish   200 FSKFEISRDSVLLIRKSKLDQQFEMESSTVKTDLVHFIRLYEMELVTEYNGVTASKILNSVILNH 264

  Fly   257 LLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLE 321
            ||.|:|:..|..|:..:..:..|:::|..:|||.|...|..:.|:.|:|.:..||.|.:|::.|.
Zfish   265 LLLFISKTEGGFEEIYNAYETTAERFRGKVLFVLIDVSELRNGRMMEYFHVRSEEAPQVRMVNLS 329

  Fly   322 EDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSK 386
            .:: :|:..||.....|:..|...:||||:|..:.|:.:|.:||..|||.||..|||.||.:.:.
Zfish   330 NNL-QYQLPSDQFDTHTLMEFCLNYLDGKVKPKMQSEPVPANWDTQPVKELVGMNFEKVAFNHNN 393

  Fly   387 SVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF-RKED 450
            :|:|.|||||...|:.|.|::::||:.:...:|:|:||:|.|||::.......:|:||.| ....
Zfish   394 NVIVLFYAPWNSECRALFPLWEELADHFSQTQDVVVAKIDITANDIHLHLGEKYPSIKLFPALYS 458

  Fly   451 NKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETE------EEEEAPKKDEL 496
            .:||.::..|.|...|.|:....|.|.::..:|.:      |:::|.:|:||
Zfish   459 ERVIPYSGKRKLKPIVTFMKIEIEKAKTDKAKEEQRRKKYLEDQKAAQKEEL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	148/451 (33%)
		pdi_dom	33..133	CDD:273454	34/102 (33%)
		PDI_b_family	137..231	CDD:239279	26/94 (28%)
		PDI_b'_family	244..347	CDD:239280	32/102 (31%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	39/101 (39%)
zgc:136472	NP_001035331.1	ER_PDI_fam	31..478	CDD:273457	148/447 (33%)
		PDI_a_family	34..122	CDD:239259	32/87 (37%)
		PDI_b_family	147..240	CDD:239279	25/92 (27%)
		PDI_b'_family	252..354	CDD:239280	32/102 (31%)
		PDI_a_PDI_a'_C	375..477	CDD:239293	39/101 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591989
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.810