DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pdi and PDIA2

DIOPT Version :9

Sequence 1:NP_001287070.1 Gene:Pdi / 39651 FlyBaseID:FBgn0286818 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_006840.2 Gene:PDIA2 / 64714 HGNCID:14180 Length:525 Species:Homo sapiens


Alignment Length:500 Identity:208/500 - (41%)
Similarity:307/500 - (61%) Gaps:32/500 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAK 84
            |.|:..|:|:||.:.......:.::..:||||||||||||:||||||:|||..||.:...:.|||
Human    35 EEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAK 99

  Fly    85 VDATVEGELAEQYAVRGYPTLKFFRSGS---PVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADA 146
            ||...:.||||::.|..||||||||:|:   |.||:|.|.|..|..|:.::.||.|..|...|.|
Human   100 VDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAA 164

  Fly   147 EQFLKDNEIAIIGFFKDLESEEAKTFTKVA-NALDSFVFGVSSNADVIAKYEAKDNGVVLFKPFD 210
            :..:...::.:||||:||:.|:..||..:| :||| ..||::....:..::....:.|||||.||
Human   165 QALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD-MTFGLTDRPRLFQQFGLTKDTVVLFKKFD 228

  Fly   211 DKKSVFEGELNEE------NLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFVSREGGHIE 269
            :.::.|  .::||      :|.:|....|:.|:.:||.::::|||...|.:|||.||::......
Human   229 EGRADF--PVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHR 291

  Fly   270 KYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAKYKP-ESDD 333
            :.:....|.|.::|..:|||.:.. ..|:..:.::||:..|..||:||:.| |...||.| :...
Human   292 ELLAGFGEAAPRFRGQVLFVVVDV-AADNEHVLQYFGLKAEAAPTLRLVNL-ETTKKYAPVDGGP 354

  Fly   334 LSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCG 398
            ::|.:|.||....|:|::|.:|||||:|.|||:.|||.||..|||.||.|::|:|.|:||||||.
Human   355 VTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCT 419

  Fly   399 HCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF-RKEDNKVIDFNLDRTL 462
            |||::||.::.|||||:|:|||:||::|:|||||::..:..|||:||| .....|||::...|.|
Human   420 HCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDL 484

  Fly   463 DDFVKFLDANGEVADSEPVEETEEEEEAP-----------KKDEL 496
            :.|.|||| ||.|.   |.||..||..||           .|:||
Human   485 ETFSKFLD-NGGVL---PTEEPPEEPAAPFPEPPANSTMGSKEEL 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PdiNP_001287070.1 ER_PDI_fam 27..474 CDD:273457 193/458 (42%)
pdi_dom 33..133 CDD:273454 50/102 (49%)
PDI_b_family 137..231 CDD:239279 31/100 (31%)
PDI_b'_family 244..347 CDD:239280 32/103 (31%)
PDI_a_PDI_a'_C 368..469 CDD:239293 55/101 (54%)
PDIA2NP_006840.2 ER_PDI_fam 42..497 CDD:273457 194/460 (42%)
Thioredoxin_like 62..151 CDD:294274 50/88 (57%)
PDI_b_family 157..254 CDD:239279 30/99 (30%)
PDI_b'_family 259..368 CDD:239280 34/110 (31%)
PDI_a_PDI_a'_C 389..491 CDD:239293 55/101 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..525 12/36 (33%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 522..525 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156371
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0190
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53639
OrthoDB 1 1.010 - - D222522at33208
OrthoFinder 1 1.000 - - FOG0000292
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18929
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X241
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.820

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