DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and TMX4

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_066979.2	Gene:	TMX4 / 56255	HGNCID:	25237	Length:	349	Species:	Homo sapiens

Alignment Length:	346	Identity:	74/346 - (21%)
Similarity:	126/346 - (36%)	Gaps:	84/346 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEG-VLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPE-- 65
            |:.|...|.:..|...||.:..|:. |...|..|: .|:.:.|::| :||||||..|:....|
Human    13 LLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNW-TLVMEGEWML-KFYAPWCPSCQQTDSEWE 75

  Fly    66 -YAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWV 129
             :||..:.|     .|.:.|||...|..|:.::.|...|.....:.|....|.|.....|:..::
Human    76 AFAKNGEIL-----QISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDGIFRRYRGPGIFEDLQNYI 135

  Fly   130 TKKTGPPAKDLT---SVADAEQFLKDNEIAIIGFFKDLESEEAKTF------TKVANALDSFVFG 185
            .:|.....:.||   |.|...........:|.|....|.:....|.      :.|...:.:.|||
Human   136 LEKKWQSVEPLTGWKSPASLTMSGMAGLFSISGKIWHLHNYFTVTLGIPAWCSYVFFVIATLVFG 200

  Fly   186 VSSNADVIAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFG 250
            :.....::...|.      .:.|.....|    |.:|:|.:
Human   201 LFMGLVLVVISEC------FYVPLPRHLS----ERSEQNRR------------------------ 231

  Fly   251 GSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTI 315
                       |.|....|:..|     |::.:||      |::||:...:.:    ::||...:
Human   232 -----------SEEAHRAEQLQD-----AEEEKDD------SNEEENKDSLVD----DEEEKEDL 270

  Fly   316 RLIKLEEDMAKYKPESDDLSA 336
            .    :||.|:.:.|.|:|:|
Human   271 G----DEDEAEEEEEEDNLAA 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	67/323 (21%)
		pdi_dom	33..133	CDD:273454	28/102 (27%)
		PDI_b_family	137..231	CDD:239279	18/102 (18%)
		PDI_b'_family	244..347	CDD:239280	19/93 (20%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
TMX4	NP_066979.2	PDI_a_TMX	37..137	CDD:239292	29/106 (27%)
TMX4	NP_066979.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..349		21/117 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156382
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840