DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and txndc16

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_685017.4	Gene:	txndc16 / 556973	ZFINID:	ZDB-GENE-100712-1	Length:	804	Species:	Danio rerio

Alignment Length:	440	Identity:	93/440 - (21%)
Similarity:	149/440 - (33%)	Gaps:	148/440 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 TVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWV--------TKKTGPPAKDLTSVA 144
            |.|..|.:.|..||...|:.|...:..:.:.      |::.|        ......||:    :.
Zfish    88 TGEKLLTKAYLFRGSEVLRSFDIDTVFDVNA------IVSHVLFSVLFNEVLYVHTPAE----LL 142

  Fly   145 DAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKYE---------AKD 200
            ..|...|.|...::|....|...|.:...:.|     ||:|        .||:         .|.
Zfish   143 GVESAAKQNSDIVVGHIPVLGLPEHRALMETA-----FVYG--------TKYQFVQTTGSLVLKR 194

  Fly   201 NGVVLFKPFDDK--------KSV-----------FEGELNEENLKKFAQVQSLPLI--------- 237
            .|||  .|...:        |||           ....:|..|:..|.|:...||:
Zfish   195 MGVV--NPSSSQARLWFLHCKSVSLQSDPCPSTAMSKPINTINIHTFLQLMEAPLVTEAVTDPSE 257

  Fly   238 VDFNHESAS----KIFGGSIKSHL-----------------LFFVSREGGHIEKYVDPLKEIAKK 281
            ||..|...|    .:|......||                 :..:.|:.   .|...|||..| .
Zfish   258 VDVVHIHLSVPVLYLFSQPQTQHLDRDTAQTVALQLRGEVGVVLIHRDN---PKVKTPLKYNA-A 318

  Fly   282 YR---DDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIK---LEEDMAKYKPESDDLSAETIE 340
            ||   :|:.:.|:|:.||                 .::|.|   |::|..:.:.|.|:..::
Zfish   319 YRLPQEDVKYFTLSAPEE-----------------VVKLFKETLLQKDKTEDEEEDDEHWSD--- 363

  Fly   341 AFLKKFLDGKLKQHLLSQELPED--------WDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWC 397
                  ||      :|..|:.|.        .|..||..|.:..|:: |:.:::..:|.||..|.
Zfish   364 ------LD------ILDDEVSESVYRDRDLMLDLEPVTELTADTFQT-AIKQNEITVVLFYFKWD 415

  Fly   398 GHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESI----KISSFPTI 443
            ..|......|.::||..:|...:.:|.:|  ..|...|    .|:||||:
Zfish   416 AVCMAFIQSYVEVAEAVEDVNGVELAAVD--CGEWTDICRDQNITSFPTV 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	93/440 (21%)
		pdi_dom	33..133	CDD:273454	10/52 (19%)
		PDI_b_family	137..231	CDD:239279	24/121 (20%)
		PDI_b'_family	244..347	CDD:239280	23/129 (18%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	23/80 (29%)
txndc16	XP_685017.4	PDI_a_family	389..489	CDD:239259	21/78 (27%)
txndc16	XP_685017.4	Thioredoxin_6	530..722	CDD:290560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910