DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pdi and TMX3

DIOPT Version :9

Sequence 1:NP_001287070.1 Gene:Pdi / 39651 FlyBaseID:FBgn0286818 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_061895.3 Gene:TMX3 / 54495 HGNCID:24718 Length:454 Species:Homo sapiens


Alignment Length:376 Identity:93/376 - (24%)
Similarity:166/376 - (44%) Gaps:69/376 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 ALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQ 71
            ||.|.|:.|.    .::.|.:|.:....::||: ..:::..||:||||||||||.|.|.:.:...
Human     9 ALRLCATVVV----LDMVVCKGFVEDLDESFKE-NRNDDIWLVDFYAPWCGHCKKLEPIWNEVGL 68

  Fly    72 QLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKKTGPP 136
            ::....||:|:.|:|||....:|.::.||||||:|..:......|.|.|...|||.:..:.:|..
Human    69 EMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGAL 133

  Fly   137 AKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKYEAKDN 201
            .:.|.|....|...|.:.:..:  :...||...:.:...|:.|..:.:..|::.:|:.:|.....
Human   134 IRPLPSQQMFEHMQKRHRVFFV--YVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKE 196

  Fly   202 --GVVLFKPFDDKKSVF----EGEL----NEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
              .|::||  |:...|:    :|:|    |.|..:.:..:....|     :|     .|.:.|..
Human   197 MPAVLVFK--DETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLL-----YE-----LGDTGKLV 249

  Fly   257 LLFFVSREGGHIE--KYVDPLKEIAKKYRD----DILFVTISSDEEDHTRIFEFFGMNKEEVPTI 315
            .|..:..:...:|  :....::|:|:.|||    |..|..:..::..:|.:     |::..|||:
Human   250 ALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLL-----MDELTVPTV 309

  Fly   316 --------------RLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLK 352
                          |.||..|||.:               |:...|||.::
Human   310 VVLNTSNQQYFLLDRQIKNVEDMVQ---------------FINNILDGTVE 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PdiNP_001287070.1 ER_PDI_fam 27..474 CDD:273457 87/356 (24%)
pdi_dom 33..133 CDD:273454 37/99 (37%)
PDI_b_family 137..231 CDD:239279 20/103 (19%)
PDI_b'_family 244..347 CDD:239280 23/122 (19%)
PDI_a_PDI_a'_C 368..469 CDD:239293
TMX3NP_061895.3 PDI_a_TMX3 27..130 CDD:239298 37/103 (36%)
ER_PDI_fam 29..>346 CDD:273457 86/352 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 412..454
Di-lysine motif 451..454
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156368
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.