Protein Alignment Pdi and TXNDC11

DIOPT Version :9

• Sequence 1: NP_001287070.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_011520817.1
• Gene: TXNDC11 / 51061
• HGNCID: 28030
• Length: 998
• Species: Homo sapiens
• Alignment Length: 769
• Identity: 138/769 - (17%)
• Similarity: 242/769 - (31%)
• Gaps: 295/769 - (38%)

  Fly     6 CALFLAASYVAASAEAEV----------KVEEGVL---VATVDNFKQLIADNEFVLVEFYAPWCG 57
            |||.||..:..:.|:..:          .:...||   ...:|..:.:..|:|.||:.|||||||
Human    74 CALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCG 138

  Fly    58 HCKALAPEYAKAAQQLAEKESPIKLAKVDA-TVEGELAEQYAVRGYPTLKFF-RSGSPVEYSGGR 120
            ...|...|..:||.:|:::   :....::. ..:|:..:|.....:|.:..: ||..|:||.|..
Human   139 QSIAARAEIEQAASRLSDQ---VLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPM 200

  Fly   121 QAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTF-TKVANALDSF-- 182
            .|..|..:| ::...|...:.|.::...||.:.|..::|:|:...|.:...: |...:||.|.
Human   201 SAVYIEKFV-RRVMKPLLYIPSQSELLDFLSNYEPGVLGYFEFSGSPQPPGYLTFFTSALHSLKK 264

  Fly   183 -----------------------------VFGVSSNAD------------VIAKYEAK------D 200
                                         |.|||..|.            :..|:.||      .
Human   265 VETGFHRFRQHRLDPRPRDPPTSASQSAGVTGVSQRARPDDYLGTVRFGVITNKHLAKLVSLVHS 329

  Fly   201 NGVVLFKPFDDKKSVFEGEL---NEENLKKFAQVQSLPLIVDFN----HESASKIFGGSIK---S 255
            ..|.|.:.| :...||..|:   ..||:.|:|......|   |.    |...|.:....:|   :
Human   330 GSVYLHRHF-NTSLVFPREVLNYTAENICKWALENQETL---FRWLRPHGGKSLLLNNELKKGPA 390

  Fly   256 HLLFFVSREGGHIEKYVDPLKEIAKKYR----DDIL----------------------------- 287
            ..||............:|.:.|:|.:|.    |.::
Human   391 LFLFIPFNPLAESHPLIDEITEVALEYNNCHGDQVVERLLQHLRRVDAPVLESLALEVPAQLPDP 455

  Fly   288 ----------------------------------------------------------------- 287
                                                                             
Human   456 PTITASPCCNTVVLPQWHSFSRTHNVCELCVNQTSGGMKPSSVSVPQCSFFEMAAALDSFYLKEQ 520

  Fly   288 -FVTISSDEEDHTRI------FEFFG-------------MNKE----EVPTIRLIKLE------- 321
             |..::||..:.:..      |.::.             ::.|    |.||:....||
Human   521 TFYHVASDSIECSNFLTSYSPFSYYTACCRTISRGVSGFIDSEQGVFEAPTVAFSSLEKKCEVDA 585

  Fly   322 -------EDMAKYKPESD----------------------------------------------- 332
                   |:.....||.|
Human   586 PSSVPHIEENRYLFPEVDMTSTNFTGLSCRTNKTLNIYLLDSNLFWLYAERLGAPSSTQVKEFAA 650

  Fly   333 --DLSAE--------------TIEAFLKKF--LDGKLKQHLLSQELPEDWDKNPVKVLVSSNFES 379
              |:..|              |:|:|::.|  |...||:||:.....:...::.:..:.:..|..
Human   651 IVDVKEESHYILDPKQALMKLTLESFIQNFSVLYSPLKRHLIGSGSAQFPSQHLITEVTTDTFWE 715

  Fly   380 VALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELE-SIKISSFPTI 443
            |.|.| :.||:.:||||||.|..|..|:.|||... ..:...:|::|.:.|:|. ...:...||:
Human   716 VVLQK-QDVLLLYYAPWCGFCPSLNHIFIQLARNL-PMDTFTVARIDVSQNDLPWEFMVDRLPTV 778

  Fly   444 KYF---RKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKD 494
            .:|   ||:.:.....::..||.:.::|:     :..|:|....:....:|.|:
Human   779 LFFPCNRKDLSVKYPEDVPITLPNLLRFI-----LHHSDPASSPQNVANSPTKE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	128/716 (18%)
		pdi_dom	33..133	CDD:273454	29/101 (29%)
		PDI_b_family	137..231	CDD:239279	29/146 (20%)
		PDI_b'_family	244..347	CDD:239280	29/306 (9%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	29/104 (28%)
TXNDC11	XP_011520817.1	PDI_a_EFP1_N	97..209	CDD:239304	30/114 (26%)
		PDI_a_PDI_a'_C	705..807	CDD:239293	29/103 (28%)
		RILP-like	<843..928	CDD:304877

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810