DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and pdia2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001011281.1	Gene:	pdia2 / 496734	XenbaseID:	XB-GENE-5770794	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	519	Identity:	203/519 - (39%)
Similarity:	321/519 - (61%)	Gaps:	29/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEA------------EVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWC 56
            |:|..:..|....|::|.            |:..|:.|||....||.:.:...:::|||||||||
Frog    11 LLCTFYTVALGQNATSEEPTKNSSEEETSDELLEEDNVLVLNKKNFDKALETYKYLLVEFYAPWC 75

  Fly    57 GHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGS---PVEYSG 118
            |||:.|||:|||||:.|.:|...::|||||||||.||:.::.|.||||||||:.|:   .::|.|
Frog    76 GHCQELAPKYAKAAEILKDKSEEVRLAKVDATVESELSMEFNVNGYPTLKFFKGGNRTGHIDYGG 140

  Fly   119 GRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFV 183
            .|....::.|:.::.||.|..|..|..||:|....|..:|||||:.|..:.|.|.:.|...:.|.
Frog   141 KRDQDGLVKWMLRRLGPAAIVLDKVESAEKFTSSQESPVIGFFKNPEDADIKIFYEAAELNEDFT 205

  Fly   184 FGVSSNADVIAKYEAKDNGVVLFKPFDDKKSVFEGE---LNEENLKKFAQVQSLPLIVDFNHESA 245
            |.::.:|.:..|:...::.|:.||..::|......|   |:::.|.||.::.::.|:.:::.|::
Frog   206 FALAHDAKLFEKFGVTEDTVIFFKNSEEKPEFKVDEDLGLDKDELSKFLKINNIDLVTEYSAETS 270

  Fly   246 SKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKE 310
            .|||...|.:|||.|:::........::..::.|..::..||||.|.|| ...:.:.|:||:...
Frog   271 DKIFAAQIPNHLLLFINKTEDSQLALLEHFRKAATHFKGKILFVFIDSD-GGFSSVLEYFGLKSS 334

  Fly   311 EVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSS 375
            :|||:|.|.| |.:.||..::.:::.:||:.|.:..|:|.:||:|:|:|:|.|||||||||||..
Frog   335 DVPTLRFINL-ESVKKYAFDAPEITEDTIQTFCRTVLEGNVKQNLMSEEIPADWDKNPVKVLVGK 398

  Fly   376 NFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSF 440
            |||.||.|:||||.||||||||.|||:|.|::::|.|||||:|.::|||||:||||::.:::..|
Frog   399 NFEEVAYDESKSVFVEFYAPWCSHCKELEPVWEELGEKYKDHESVIIAKMDATANEIDGLRVRGF 463

  Fly   441 PTIKYF-RKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPK-------KDEL 496
            |.:::| .....|:|::..:||::.|..|:|:.| |...|.||:..|.||:.:       ||||
Frog   464 PNLRFFPAGPGRKMIEYTKERTVELFSAFIDSGG-VLPEEQVEKDAEAEESKEVAEEDKGKDEL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	184/453 (41%)
		pdi_dom	33..133	CDD:273454	49/102 (48%)
		PDI_b_family	137..231	CDD:239279	29/96 (30%)
		PDI_b'_family	244..347	CDD:239280	31/102 (30%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	53/101 (52%)
pdia2	NP_001011281.1	YbbN	46..502	CDD:331940	186/458 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4577
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.110