DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and p4hb

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_998529.3	Gene:	p4hb / 406673	ZFINID:	ZDB-GENE-080610-1	Length:	509	Species:	Danio rerio

Alignment Length:	499	Identity:	272/499 - (54%)
Similarity:	363/499 - (72%)	Gaps:	14/499 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFLI-CALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAP 64
            :|||| |||       ||.:.||:..||.|||....||::.:..:..||||||||||||||||||
Zfish     2 LKFLIVCAL-------AAMSAAEIAEEEDVLVLKKSNFEEALKAHPNVLVEFYAPWCGHCKALAP 59

  Fly    65 EYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFR---SGSPVEYSGGRQAADII 126
            ||:|||..|..:.|.|:|||||||.|.|||:::.||||||:|||:   .|:|.|||.||||.||:
Zfish    60 EYSKAAGMLKAEGSDIRLAKVDATEESELAQEFGVRGYPTIKFFKGGEKGNPKEYSAGRQAEDIV 124

  Fly   127 AWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNAD 191
            :|:.|:|||.|..|..|..||..:.|||:|:||||||:|||::|.|.|.|.|:|...||::|:..
Zfish   125 SWLKKRTGPAATTLNDVMQAESIIADNEVAVIGFFKDVESEDSKAFIKTAEAVDDIPFGITSDDS 189

  Fly   192 VIAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
            |.||:|...:.|||||.||:.::.|:||:::|:|..|.:...|||:::|..::|.|||||.||||
Zfish   190 VFAKFEVAKDSVVLFKKFDEGRNTFDGEVSKESLLNFIKANQLPLVIEFTEQTAPKIFGGDIKSH 254

  Fly   257 LLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLE 321
            :|.||.:.....:..:|..|:.|:.::..|||:.|.||.:|:.||.||||:.|||.|.||||.||
Zfish   255 ILMFVPKAAKDFQDKMDQFKKAAEGFKGKILFIFIDSDVDDNQRILEFFGLKKEECPVIRLITLE 319

  Fly   322 EDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSK 386
            |:|.||||||.:::||.|.:|...|::|.||.||:||::|||||||||||||..|||.||.:.:.
Zfish   320 EEMTKYKPESSEITAENIISFCTSFVEGTLKPHLMSQDIPEDWDKNPVKVLVGKNFEEVAFNPAN 384

  Fly   387 SVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF-RKED 450
            :|.|||||||||||||||||:|||.||:|||.:||:|||||||||:|::|:.||||:|:| ..::
Zfish   385 NVFVEFYAPWCGHCKQLAPIWDQLGEKFKDNANIVVAKMDSTANEIEAVKVHSFPTLKFFPAGDE 449

  Fly   451 NKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKD 494
            .||||:|.:||||.|.|||::.|:...: ||.: ||:|||...|
Zfish   450 RKVIDYNGERTLDGFTKFLESGGKEGGA-PVGD-EEDEEADDLD 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	251/450 (56%)
		pdi_dom	33..133	CDD:273454	61/102 (60%)
		PDI_b_family	137..231	CDD:239279	44/93 (47%)
		PDI_b'_family	244..347	CDD:239280	51/102 (50%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	67/101 (66%)
p4hb	NP_998529.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591985
Domainoid	1	1.000	185	1.000	Domainoid score	I3322
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55495
Inparanoid	1	1.050	546	1.000	Inparanoid score	I1121
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto39094
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910