Protein Alignment Pdi and txndc5

DIOPT Version :10

• Sequence 1: NP_524079.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_998181.2
• Gene: txndc5 / 406289
• ZFINID: ZDB-GENE-040426-1951
• Length: 403
• Species: Danio rerio
• Alignment Length: 472
• Identity: 118/472 - (25%)
• Similarity: 187/472 - (39%)
• Gaps: 128/472 - (27%)

  Fly     3 FLICALFLAASYVAASAEAEVKVEEGVL-VATVDNFKQLIAD-NEFVLVEFYAPWCGHCKALAPE 65
            ||...::||......|.:.:.:.:|... ..||:.|...|:. ..||:  |:|||||||:.|...
Zfish     4 FLTSFIYLALLCSRLSCDNDTEEDEHAKHTYTVEMFNDAISTAPHFVM--FFAPWCGHCQRLQGT 66

  Fly    66 YAKAAQQLAEKES-PIKLAKVDATVEGELAE-QYAVRGYPTLKFFR-SGSPVEYSGGRQAADIIA 127
            :.:.|.:....|: |..:.|||.|.:.:... ::.:|||||||.|: ....|:|.|.|....:..
Zfish    67 WNELADKYNSMEAPPAYVVKVDCTKDTKFCSIEHGIRGYPTLKLFKPEQEAVKYQGPRDLQALEN 131

  Fly   128 WVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADV 192
            |:.|......::..|                      |.|..|.
Zfish   132 WMLKTLQEEPEEPQS----------------------EPEPPKV--------------------- 153

  Fly   193 IAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHL 257
                           | :.|:.::  ||...|.|                   |.|..|   ||.
Zfish   154 ---------------P-EPKQGLY--ELTATNFK-------------------SHIAKG---SHF 178

  Fly   258 LFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNK-EEVPTIRLIKLE 321
            :.|.:...||.:......:::|..:...   .:|...:.|.|:.:|....|: ...||:......
Zfish   179 VKFFAPWCGHCKAMAPTWEQLASSFEHS---DSIKISKVDCTQHYEVCSDNQVRGYPTLLFFTDG 240

  Fly   322 EDMAKYKPESDDLSAETIEAFLKKFLDGKLK------------QHLLSQEL-----PEDWDKNPV 369
            |.:.:||.:.|      :::| |:|:|..:|            :|  :.|:     ||..:.| |
Zfish   241 EKIDQYKGKRD------LDSF-KEFVDNHVKAAESKDEPEKEEEH--THEIPPSAEPEKQESN-V 295

  Fly   370 KVLVSSNF-ESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEK-YKDNEDIVIAKMDSTANE- 431
            .||..||| |:||...|   .::||||||||||.|||.:|.|::| :....|:.|||:|.|...
Zfish   296 LVLTESNFDETVAKGLS---FIKFYAPWCGHCKNLAPTWDDLSQKEFPGLTDVKIAKVDCTVERT 357

  Fly   432 -LESIKISSFPTIKYFR 447
             .....:..:||:..||
Zfish   358 LCNRFSVRGYPTLLMFR 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_524079.1	ER_PDI_fam	27..474	CDD:273457	113/448 (25%)
txndc5	NP_998181.2	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	34..133	CDD:469754	34/100 (34%)
		PDI_a_ERp46	159..259	CDD:239303	26/133 (20%)
		PDI_a_ERp46	294..395	CDD:239303	37/85 (44%)