DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and pdia2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001307463.1	Gene:	pdia2 / 394023	ZFINID:	ZDB-GENE-040426-705	Length:	555	Species:	Danio rerio

Alignment Length:	546	Identity:	218/546 - (39%)
Similarity:	323/546 - (59%)	Gaps:	55/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEG---------------------VLVATVDNFKQLIADNEFV 47
            |:|.|...|.......::|.|||:.                     ||:....||.:.:::|:::
Zfish    12 LVCGLCARADEENTEEKSEEKVEDNSEEDTEPEKPEKTDEITEDKDVLILHSVNFDRALSENKYL 76

  Fly    48 LVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG- 111
            ||||||||||||::|.|.||:.|.||....|.::||||||..|.|||.:::|..:||||||:.|
Zfish    77 LVEFYAPWCGHCRSLEPIYAEVAGQLKNASSEVRLAKVDAIEEKELASEFSVDSFPTLKFFKEGN 141

  Fly   112 --SPVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTK 174
              :...:.|.|....|..|:.|.|.|.|..|..|..||..|:.||:.::|||||||.|:||||..
Zfish   142 RQNATTFFGKRTLKGIKRWLEKHTAPSATVLNDVKSAEALLEANEVLVVGFFKDLEGEKAKTFYD 206

  Fly   175 VANALDSFVFGVSSNADVIAKYEAKDNGVVLFKPFDDKKSVF----EGELNEENLKKFAQVQSLP 235
            |........||::|:.::..|||.|.:.:||||.||::::..    |.:|::..:..|....|:.
Zfish   207 VTLIAVDVNFGITSDPELFKKYEVKTDSLVLFKKFDERRADMPLSDETKLDKGEMISFIHSNSMR 271

  Fly   236 LIVDFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTR 300
            |:|.||.|:|.:||...::.|||.|::.........|:..:|:|.::::.::|:|:....|....
Zfish   272 LVVPFNEENAEQIFNSKVRKHLLLFLNTTVDSQNALVEEFREVASEFKEKVIFITVDVTAEKVNH 336

  Fly   301 IFEFFGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWD 365
            :.::|.:::::|||||||. .||:..|..:...::.:|:..|.:...||.:|.:|.|||:|||||
Zfish   337 VLKYFSISEDDVPTIRLIN-TEDVVTYAMDGSTINKDTLRTFCQGVFDGTVKPYLKSQEIPEDWD 400

  Fly   366 KNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTAN 430
            ||||||||..||..||.|:||:|.|||||||||||:||||::|:|.|||||.|:|:|||||:|.|
Zfish   401 KNPVKVLVGKNFNEVAFDESKNVFVEFYAPWCGHCQQLAPVWDELGEKYKDQENIIIAKMDATEN 465

  Fly   431 ELESIKISSFPTIKYF-RKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEE------- 487
            ::|.:.|..||||||| ...:.|::|::.:|.|:.|.|||| ||.|...|..:|.|::
Zfish   466 DVEDLTIQGFPTIKYFPAGTEKKIVDYDGNRDLETFSKFLD-NGGVLPKEESKEDEDDDDDDNDD 529

  Fly   488 -----------EEAPK------KDEL 496
                       ||:||      ||||
Zfish   530 DDEDKPTDESKEESPKATNETDKDEL 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	197/475 (41%)
		pdi_dom	33..133	CDD:273454	46/102 (45%)
		PDI_b_family	137..231	CDD:239279	37/97 (38%)
		PDI_b'_family	244..347	CDD:239280	26/102 (25%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	60/101 (59%)
pdia2	NP_001307463.1	ER_PDI_fam	56..512	CDD:273457	199/457 (44%)
		PDI_a_family	65..161	CDD:239259	44/95 (46%)
		PDI_b_family	169..268	CDD:239279	37/98 (38%)
		PDI_b'_family	280..382	CDD:239280	26/102 (25%)
		PDI_a_PDI_a'_C	403..505	CDD:239293	60/101 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591990
Domainoid	1	1.000	148	1.000	Domainoid score	I4421
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820