DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and pdia3

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001186666.1	Gene:	pdia3 / 378851	ZFINID:	ZDB-GENE-031002-9	Length:	494	Species:	Danio rerio

Alignment Length:	520	Identity:	184/520 - (35%)
Similarity:	285/520 - (54%)	Gaps:	54/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAK 68
            ::..|||.|...||.|       ..||..|.|:|...|.|::.:||||:||||||||.|||||..
Zfish     2 MLALLFLVAFAAAARA-------SDVLEYTDDDFDSRIGDHDLILVEFFAPWCGHCKRLAPEYEA 59

  Fly    69 AAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV-EYSGGRQAADIIAWVTKK 132
            ||.:|   :..:.|||||.|...::..:|.|.||||||.||.|... .|.|.|.|..|::.:.|:
Zfish    60 AATRL---KGIVPLAKVDCTANSKVCGKYGVSGYPTLKIFRDGEDSGGYDGPRTADGIVSHLKKQ 121

  Fly   133 TGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANAL-DSFVFGVSSNADVIAKY 196
            .||.:.:|.:.||.|:::.|.:.:::|||.|..|.....|.|.|:|| :|:.|..::|.|::.|:
Zfish   122 AGPASVELKNEADFEKYIGDRDASVVGFFADGGSAAQGEFLKAASALRESYRFAHTNNEDLLKKH 186

  Fly   197 EAKDNGVVLFK------PFDDKKSVF-EGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIK 254
            .....|::||:      .|:|...:| |.:.....:|||.|.....:......::..::.|   |
Zfish   187 GIDGEGIILFRSPQLSNKFEDSSVLFTEDKFTSAKIKKFIQDNIFGICAHMTEDNKDQLKG---K 248

  Fly   255 SHLLFFVSREGGHIEK-------YVDPLKEIAKKYRDD---ILFVTISSDEEDHTRIFEFFGM-- 307
            ..|:.:...:   .||       :.:.:.::||.:.|.   :.|...:.:...|. :.| .|:
Zfish   249 DLLVAYYDVD---YEKNPKGSNYWRNRVMKVAKGFLDQGKKLSFAVANKNRFSHD-VSE-LGLDG 308

  Fly   308 NKEEVPTIRLIKLEEDMAKYKPE-SDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKV 371
            :..|:|.:.:...:.|....|.| |.|  .:.:|.||:.:.||.||::|.|:.:||:.| .||||
Zfish   309 SSGELPLVGIRTAKGDKYVMKEEFSRD--GKALERFLQDYFDGNLKRYLKSEPVPENND-GPVKV 370

  Fly   372 LVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELES-I 435
            ||:.||:|:..|.||.||:|||||||||||.|.|.|.:|.||..::.:|||||||:|||::.| .
Zfish   371 LVAENFDSIVNDDSKDVLIEFYAPWCGHCKSLEPKYKELGEKLSEDPNIVIAKMDATANDVPSPY 435

  Fly   436 KISSFPTIKYF----RKEDNKVIDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDEL 496
            ::|.|||| ||    ||::.|  .:...|.:.||:.:|  ..|..::..|:| ::::...||.||
Zfish   436 EVSGFPTI-YFSPAGRKQNPK--KYEGGREVSDFISYL--KREATNTVVVQE-DKKKSKKKKSEL 494

Fly 497 496
Zfish 495 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	170/473 (36%)
		pdi_dom	33..133	CDD:273454	48/100 (48%)
		PDI_b_family	137..231	CDD:239279	30/101 (30%)
		PDI_b'_family	244..347	CDD:239280	22/115 (19%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	55/105 (52%)
pdia3	NP_001186666.1	ER_PDI_fam	18..475	CDD:273457	171/475 (36%)
		Thioredoxin_like	19..116	CDD:294274	49/99 (49%)
		PDI_b_ERp57	125..230	CDD:239367	31/104 (30%)
		PDI_b'_ERp72_ERp57	234..347	CDD:239371	22/122 (18%)
		PDI_a_PDI_a'_C	367..470	CDD:239293	55/105 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760