DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and Pdia5

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001014147.1	Gene:	Pdia5 / 360722	RGDID:	1359236	Length:	517	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	113/507 - (22%)
Similarity:	189/507 - (37%)	Gaps:	172/507 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EAEVKVEEGVLVATVDNFKQLIADNEF-VLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLA 83
            |.:...::.|.:.:..:|::|:...|. :|:.||||||..||.:.|.:.|||.|:   .....||
  Rat   143 EEDPGAKDVVHIDSEKDFRRLLKKEEKPLLMMFYAPWCSMCKRIMPHFQKAATQV---RGHTVLA 204

  Fly    84 KVDA-TVEGE-LAEQYAVRGYPTLKFFRSGSPV-EYSG-GRQAADIIAWVTKKTGPPAKDLTSV- 143
            .::. ..|.| :.|:|.||||||:.:|..|..: :|.. |..|.||:.|: |...||...:...
  Rat   205 GMNVYPPEFENIKEEYNVRGYPTICYFEKGRFLFQYENYGSTAEDIVEWL-KNPQPPQPQVPETP 268

  Fly   144 -------------ADAEQFLKDNEIAII-------GFFKDLESEEAKTFTKVANALDSFVFGVSS 188
                         .|.:||:|::...::       |..|.::.|    |...|..|..
  Rat   269 WADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPE----FESAAEVLHG------- 322

  Fly   189 NADVIAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSI 253
                    :|:.:||:         :..:..:||...::| .:.:.|.:
  Rat   323 --------DAESSGVL---------AAVDATINEALAERF-HISAFPTL---------------- 353

  Fly   254 KSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLI 318
                                       ||                     |....::.||.:|.
  Rat   354 ---------------------------KY---------------------FKNGEQQAVPALRT- 369

  Fly   319 KLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELP----EDWDKNPVKV--LVSSNF 377
                                    .|||:     :.:.:.|.|    ..|::....|  ||..||
  Rat   370 ------------------------KKKFI-----EWMQNPEAPPPPEPTWEEQQTSVLHLVGDNF 405

  Fly   378 ESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTAN------ELESIK 436
            .. .|.|.|..||.||||||.|||::.|.:...|:.:||:..|..|.:|...:      :.||:|
  Rat   406 RE-TLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQESVK 469

  Fly   437 ISSFPTIKYFRKEDNKVID-FNLDRTLDDFVKFLDANGEVADSEPVEETEEE 487
              ::||..|:..  .|::: :..|||...|..|:....| .|.:.:|:..|:
  Rat   470 --AYPTFHYYHY--GKLVEKYESDRTELGFTSFIRTLRE-GDLKRLEKRRED 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	108/485 (22%)
		pdi_dom	33..133	CDD:273454	38/104 (37%)
		PDI_b_family	137..231	CDD:239279	16/114 (14%)
		PDI_b'_family	244..347	CDD:239280	8/102 (8%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	37/109 (34%)
Pdia5	NP_001014147.1	PDI_b_PDIR_N	26..137	CDD:239365
		PDI_a_PDIR	150..254	CDD:239295	37/106 (35%)
		ER_PDI_fam	166..501	CDD:273457	105/466 (23%)
		PDI_a_PDIR	275..377	CDD:239295	26/224 (12%)
		PDI_a_PDIR	396..499	CDD:239295	37/107 (35%)
		Prevents secretion from ER. /evidence=ECO:0000255	514..517		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910