DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Erp44

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001008318.1	Gene:	Erp44 / 298066	RGDID:	1309176	Length:	406	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	93/391 - (23%)
Similarity:	168/391 - (42%)	Gaps:	80/391 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEGVLVATVD--NFKQLIADNEFVLVEFYAPWCGHCKALAPEY 66
            |.|:|.|..:.:.|...||        :|::|  |..:::.:.:..||.|||.||...:.|.|.:
  Rat    12 LRCSLLLLVTSIFAPITAE--------IASLDSENIDEILNNADVALVNFYADWCRFSQMLHPIF 68

  Fly    67 AKAAQQLAEK---ESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV--EYSGGRQAADII 126
            .:|:..:.|:   ::.:..|:||.....::|::|.:..|||||.||:|..:  ||.|.|....:.
  Rat    69 EEASDVIKEEYPDKNQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALA 133

  Fly   127 AWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNAD 191
            .::.::...|..::.|: |....|..::..|||:|:..:|:..:.|.:||:.|......:|:..|
  Rat   134 DYIRQQKSNPVHEIQSL-DEVTNLDRSKRNIIGYFEQKDSDNYRVFERVASILHDDCAFLSAFGD 197

  Fly   192 VIAKYEAKDNGVVLFKP----------------FD-------DKKSVFEGELNEENLKKFAQVQS 233
             ::|.|......:::||                ||       ||......|:..||.::..: :.
  Rat   198 -LSKPERYSGDNLIYKPPGRSVPDMVYLGSMTNFDVTFNWIQDKCVPLVREITFENGEELTE-EG 260

  Fly   234 LPLIVDFNHE---SASKIFGGSIKSHLLFFVSREG------GHIEKYVDPLKEIAKKYRDDILFV 289
            ||.::.|:.:   .:.:||...:...|   :|.:|      ...:|:..||..|.|...|   ..
  Rat   261 LPFLILFHMKEDTESLEIFQNEVARQL---ISEKGTINFLHADCDKFRHPLLHIQKTPAD---CP 319

  Fly   290 TISSDEEDHTRIFEFF------GMNKEEVPTIRLIKL------------------EEDMAKYKPE 330
            .|:.|...|..:|..|      |..|:.|..:...||                  ::|:|...||
  Rat   320 VIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQDQDVASSPPE 384

  Fly   331 S 331
            |
  Rat   385 S 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	86/368 (23%)
		pdi_dom	33..133	CDD:273454	30/106 (28%)
		PDI_b_family	137..231	CDD:239279	25/116 (22%)
		PDI_b'_family	244..347	CDD:239280	26/118 (22%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
Erp44	NP_001008318.1	PDI_a_ERp44	29..136	CDD:239294	33/114 (29%)
		PDI_b_ERp44	144..234	CDD:239368	20/91 (22%)
		Thioredoxin_6	167..350	CDD:290560	41/190 (22%)
		PDI_b'_ERp44	245..355	CDD:239370	25/116 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910