DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and Erp27

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001100095.1	Gene:	Erp27 / 297698	RGDID:	1565381	Length:	272	Species:	Rattus norvegicus

Alignment Length:	240	Identity:	56/240 - (23%)
Similarity:	121/240 - (50%)	Gaps:	12/240 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 GPPAKD--LTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKY 196
            |.|.:.  ||.:....:.:...|:|:||||:|||......|..:|.......||:|::::|:..|
  Rat    35 GTPREPRWLTDIPATVELIAAAEVAVIGFFQDLEIPIVSIFRSMAQQFQDVSFGISNHSEVLTHY 99

  Fly   197 EAKDNGVVLFKPFDDKKSVFEGE----LNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHL 257
            ....|.:.||:..|:|:...:.|    |:...|.:|..:.:|..:.:::....:.:|...:::||
  Rat   100 NVTSNSICLFRLVDNKQLRLDAEDIDDLDAAKLSRFIHLNNLHWVTEYSPMIGAGLFNTMVQTHL 164

  Fly   258 LFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEE 322
            |..:::.....|:.:...::.||.::..||||.:.|.:.::.::..:|.:.:.::|.:.:.:..:
  Rat   165 LLIMNKASPEYEESLRSYQKAAKLFQGQILFVLVDSGKRENGKVIAYFRLKESQLPALAIYESVD 229

  Fly   323 DMAKYKPES-DDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDK 366
            |  |:...: .:::.|.:::|...||.|.|   |..|:...|..|
  Rat   230 D--KWDALTITEVTVEKVQSFCNGFLKGML---LRDQKAENDSGK 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	56/240 (23%)
		pdi_dom	33..133	CDD:273454
		PDI_b_family	137..231	CDD:239279	27/99 (27%)
		PDI_b'_family	244..347	CDD:239280	18/103 (17%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
Erp27	NP_001100095.1	PDI_b_family	43..139	CDD:239279	27/95 (28%)
		Thioredoxin_6	64..250	CDD:290560	39/187 (21%)
		PDI_b'_family	156..253	CDD:239280	18/98 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D462118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.910