Protein Alignment Pdi and Pdia3

DIOPT Version :10

• Sequence 1: NP_524079.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_063139286.1
• Gene: Pdia3 / 29468
• RGDID: 68430
• Length: 558
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 163/496 - (32%)
• Similarity: 257/496 - (51%)
• Gaps: 72/496 - (14%)

  Fly     1 MKFLICALFLAASYVAAS---AEAEVKVEEGVLVATVDNFKQLIADN---EFVLVEFYAPWCGHC 59
            |:|...||....:.:.||   |.|.:.....||..|.:||:..::|.   ..:||||:|||||||
  Rat     1 MRFSCLALLPGVALLLASALLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHC 65

  Fly    60 KALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV-EYSGGRQAA 123
            |.|||||..||.:|   :..:.|||||.|.......:|.|.||||||.||.|... .|.|.|.|.
  Rat    66 KRLAPEYEAAATRL---KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTAD 127

  Fly   124 DIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVA-NALDSFVFGVS 187
            .|::.:.|:.||.:..|.:..:.::|:.|.:.:::|||:||.|:....|.|.| |..|::.|..:
  Rat   128 GIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHT 192

  Fly   188 SNADVIAKYEAKDNGVVLFKP------FDDKKSVF-EGELNEENLKKFAQ--------------- 230
            :...::.:|:....|:.:|:|      |:||...: |.::....:|||.|
  Rat   193 NVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNK 257

  Fly   231 --VQSLPLIV---DFNHESASKIFGGSIKSHLLFFVSR---EGGHIEKYVDPLKEIAKKYRDDIL 287
              :|...|:.   |.::|..:|  |.:...:.:..|::   :.||...:.     :|.:
  Rat   258 DLIQGKDLLTAYYDVDYEKNTK--GSNYWRNRVMMVAKTFLDAGHKLNFA-----VASR------ 309

  Fly   288 FVTISSDEEDHTRIFEFFGMNKE--EVP--TIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLD 348
             .|.|.:..|       ||:...  |:|  .||..|.|:.:.:   |......:.:|.||:::.|
  Rat   310 -KTFSHELSD-------FGLESTTGEIPVVAIRTAKGEKFVMQ---EEFSRDGKALERFLQEYFD 363

  Fly   349 GKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEK 413
            |.||::|.|:.:||. ::.||||:|:.:|:.:...:.|.||:|||||||||||.|.|.|.:|.||
  Rat   364 GNLKRYLKSEPIPET-NEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEK 427

  Fly   414 YKDNEDIVIAKMDSTANELES-IKISSFPTIKYFRKEDNKV 453
            ...:.:|||||||:|||::.| .::..|||| ||...:.|:
  Rat   428 LSKDPNIVIAKMDATANDVPSPYEVKGFPTI-YFSPANKKL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_524079.1	ER_PDI_fam	27..474	CDD:273457	155/467 (33%)
Pdia3	XP_063139286.1	None