DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and Pdilt

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_038963539.1	Gene:	Pdilt / 293544	RGDID:	1307822	Length:	615	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	144/524 - (27%)
Similarity:	267/524 - (50%)	Gaps:	36/524 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFLAA--SYVAASAEAEVKV----------EEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCK 60
            |.|||  |.|..|.|.:..:          :..::|.|.....|.:.:..|::|.|:.|.....:
  Rat    34 LLLAACLSEVLGSPEMDTGINISQPLHILEDHNLMVLTPAGLTQTLNETRFLMVIFHNPTLKQSR 98

  Fly    61 ALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGS---PVEYSGGRQA 122
            .||.|..|||:...:.::.:...|||.|:|.||.:::.:...|.||.|..|:   |:......::
  Rat    99 KLAKELGKAAEIFGKGKNGLGFGKVDITMETELKQEFDITHAPELKLFYEGNRLEPISCKDVVES 163

  Fly   123 ADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVS 187
            ..::.|:.::....|....:..:...|:|...:.|:|||:|||.|.|:.|...........||..
  Rat   164 TALVVWLRRQISKKALLFNNSNEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAI 228

  Fly   188 SNADVIAKYEAKDNGVVLFKP--FDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFG 250
            ...:...::....:.|::||.  ...::.:.....|::.|.:..:.|....:::||.|:...|:.
  Rat   229 QIKNSFGRFHVILDSVLVFKKGRVVKRQELINDSTNKDYLNQVIKQQLTGFVIEFNPENKDLIYE 293

  Fly   251 GSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTI 315
            .:|.:|:|.|:|:........:...::|:|::::.||||.::|||..:.||||:|.:::..||::
  Rat   294 MNILNHMLLFISKNSEPYSTIIRHYRQISKEFQNKILFVLVNSDEPKNKRIFEYFQISRVNVPSV 358

  Fly   316 RLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESV 380
            :::.|..| |:||..:|:::.|:::.|...||....|:|..|:|:|:.||:.|||.||..||..|
  Rat   359 QILNLSSD-ARYKMPTDNITFESLKKFCNSFLSRTAKKHKSSEEIPKYWDQEPVKKLVGKNFNVV 422

  Fly   381 ALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKY 445
            ..||.|.|.|.|||||...|:.|.|:.::|..||:::..::|||:|.|||:::......:|..:.
  Rat   423 VFDKEKDVFVMFYAPWSEKCRVLLPLLEELGIKYQNHSTVIIAKIDITANDIQLANPEQYPFFRL 487

  Fly   446 FRKEDNKVIDFNLDRTLDDFVKFLDAN----------------GEVADSEPVEETEEE--EEAPK 492
            |..:..:.:.:..:.|:..|..||:::                .|||:.|.:.|.|.:  ::.|:
  Rat   488 FPTDSQEAVMYKGEHTMKGFCDFLESHVKVRIEEDDELLYIEQNEVAEEEVLAEPEMQHIDKLPE 552

  Fly   493 KDEL 496
            |..|
  Rat   553 KPPL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	127/467 (27%)
		pdi_dom	33..133	CDD:273454	26/102 (25%)
		PDI_b_family	137..231	CDD:239279	20/95 (21%)
		PDI_b'_family	244..347	CDD:239280	30/102 (29%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	35/100 (35%)
Pdilt	XP_038963539.1	ER_PDI_fam	69..523	CDD:273457	127/454 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810