DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDIA3

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_005304.3	Gene:	PDIA3 / 2923	HGNCID:	4606	Length:	505	Species:	Homo sapiens

Alignment Length:	529	Identity:	182/529 - (34%)
Similarity:	272/529 - (51%)	Gaps:	86/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADN---EFVLVEFYAPWCGHCKALAPEYAK 68
            ||.|||:.:||:::        ||..|.|||:..|:|.   ..:||||:||||||||.|||||..
Human    13 ALLLAAARLAAASD--------VLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69

  Fly    69 AAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV-EYSGGRQAADIIAWVTKK 132
            ||.:|   :..:.|||||.|.......:|.|.||||||.||.|... .|.|.|.|..|::.:.|:
Human    70 AATRL---KGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131

  Fly   133 TGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVA-NALDSFVFGVSSNADVIAKY 196
            .||.:..|.:..:.::|:.|.:.:|:|||.|..||....|.|.| |..|::.|..::...::.:|
Human   132 AGPASVPLRTEEEFKKFISDKDASIVGFFDDSFSEAHSEFLKAASNLRDNYRFAHTNVESLVNEY 196

  Fly   197 EAKDNGVVLFKP------FDDKKSVF-EGELNEENLKKFAQ-----------------VQSLPLI 237
            :....|::||:|      |:||...: |.::....:|||.|                 :|...|:
Human   197 DDNGEGIILFRPSHLTNKFEDKTVAYTEQKMTSGKIKKFIQENIFGICPHMTEDNKDLIQGKDLL 261

  Fly   238 V---DFNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRD---DILFVTISSDEE 296
            :   |.::|..:|   ||                ..:.:.:..:|||:.|   .:.|...|....
Human   262 IAYYDVDYEKNAK---GS----------------NYWRNRVMMVAKKFLDAGHKLNFAVASRKTF 307

  Fly   297 DHTRIFEFFGMNKE--EVP--TIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLS 357
            .|.  ...||:...  |:|  .||..|.|:.:.:   |......:.:|.||:.:.||.||::|.|
Human   308 SHE--LSDFGLESTAGEIPVVAIRTAKGEKFVMQ---EEFSRDGKALERFLQDYFDGNLKRYLKS 367

  Fly   358 QELPEDWDKNPVKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVI 422
            :.:||..| .||||:|:.||:.:..:::|.||:|||||||||||.|.|.|.:|.||...:.:|||
Human   368 EPIPESND-GPVKVVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVI 431

  Fly   423 AKMDSTANELES-IKISSFPTIKYFRKEDNKV--IDFNLDRTLDDFVKFLDANGEVADSEPVEET 484
            ||||:|||::.| .::..|||| ||...:.|:  ..:...|.|.||:.:|...   |.:.||
Human   432 AKMDATANDVPSPYEVRGFPTI-YFSPANKKLNPKKYEGGRELSDFISYLQRE---ATNPPV--- 489

  Fly   485 EEEEEAPKK 493
             .:||.|||
Human   490 -IQEEKPKK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	167/488 (34%)
		pdi_dom	33..133	CDD:273454	49/103 (48%)
		PDI_b_family	137..231	CDD:239279	29/118 (25%)
		PDI_b'_family	244..347	CDD:239280	22/109 (20%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	49/103 (48%)
PDIA3	NP_005304.3	YbbN	25..487	CDD:331940	168/501 (34%)
PDIA3	NP_005304.3	ER retention motif	502..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.690