Protein Alignment Pdi and P4hb

DIOPT Version :10

• Sequence 1: NP_524079.1
• Gene: Pdi / 39651
• FlyBaseID: FBgn0286818
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_037130.2
• Gene: P4hb / 25506
• RGDID: 3244
• Length: 509
• Species: Rattus norvegicus
• Alignment Length: 507
• Identity: 270/507 - (53%)
• Similarity: 356/507 - (70%)
• Gaps: 17/507 - (3%)

  Fly     4 LICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAK 68
            |:|.....|:.|.|.|..|   |:.|||....||.:.:|.:.::|||||||||||||||||||||
  Rat     6 LLCLALAWAARVGADALEE---EDNVLVLKKSNFAEALAAHNYLLVEFYAPWCGHCKALAPEYAK 67

  Fly    69 AAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG---SPVEYSGGRQAADIIAWVT 130
            ||.:|..:.|.|:|||||||.|.:||:||.||||||:|||::|   ||.||:.||:|.||:.|:.
  Rat    68 AAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLK 132

  Fly   131 KKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAK 195
            |:|||.|..|:..|.||..:..:|:.:||||||..|:.||.|...|.|:|...||::||:||.:|
  Rat   133 KRTGPAATTLSDTAAAESLVDSSEVTVIGFFKDAGSDSAKQFLLAAEAVDDIPFGITSNSDVFSK 197

  Fly   196 YEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFF 260
            |:...:||||||.||:.::.||||:.:|.|..|.:...|||:::|..::|.|||||.||:|:|.|
  Rat   198 YQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLF 262

  Fly   261 VSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMA 325
            :.:.....:..:...|:.|:.::..|||:.|.||..|:.||.||||:.|||.|.:|||.|||:|.
  Rat   263 LPKSVSDYDGKLSNFKKAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMT 327

  Fly   326 KYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLV 390
            |||||||:|:||.|..|...||:||:|.||:||||||||||.||||||..|||.||.|:.|:|.|
  Rat   328 KYKPESDELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFV 392

  Fly   391 EFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF-RKEDNKVI 454
            ||||||||||||||||:|:|.|.|||:|:||||||||||||:|::|:.||||:|:| ...|..||
  Rat   393 EFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVI 457

  Fly   455 DFNLDRTLDDFVKFLDANGE--VADS------EPVEETEEEEEAPK--KDEL 496
            |:|.:||||.|.|||::.|:  ..|:      |.:|...||::..|  ||||
  Rat   458 DYNGERTLDGFKKFLESGGQDGAGDNDDLDLEEALEPDMEEDDDQKAVKDEL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_524079.1	ER_PDI_fam	27..474	CDD:273457	251/450 (56%)
P4hb	NP_037130.2	ER_PDI_fam	26..476	CDD:273457	251/449 (56%)
		Prevents secretion from ER	506..509		2/2 (100%)