DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and P4hb

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_037130.2	Gene:	P4hb / 25506	RGDID:	3244	Length:	509	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	270/507 - (53%)
Similarity:	356/507 - (70%)	Gaps:	17/507 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAK 68
            |:|.....|:.|.|.|..|   |:.|||....||.:.:|.:.::|||||||||||||||||||||
  Rat     6 LLCLALAWAARVGADALEE---EDNVLVLKKSNFAEALAAHNYLLVEFYAPWCGHCKALAPEYAK 67

  Fly    69 AAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG---SPVEYSGGRQAADIIAWVT 130
            ||.:|..:.|.|:|||||||.|.:||:||.||||||:|||::|   ||.||:.||:|.||:.|:.
  Rat    68 AAAKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFKNGDTASPKEYTAGREADDIVNWLK 132

  Fly   131 KKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAK 195
            |:|||.|..|:..|.||..:..:|:.:||||||..|:.||.|...|.|:|...||::||:||.:|
  Rat   133 KRTGPAATTLSDTAAAESLVDSSEVTVIGFFKDAGSDSAKQFLLAAEAVDDIPFGITSNSDVFSK 197

  Fly   196 YEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFF 260
            |:...:||||||.||:.::.||||:.:|.|..|.:...|||:::|..::|.|||||.||:|:|.|
  Rat   198 YQLDKDGVVLFKKFDEGRNNFEGEITKEKLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLF 262

  Fly   261 VSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMA 325
            :.:.....:..:...|:.|:.::..|||:.|.||..|:.||.||||:.|||.|.:|||.|||:|.
  Rat   263 LPKSVSDYDGKLSNFKKAAEGFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMT 327

  Fly   326 KYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLV 390
            |||||||:|:||.|..|...||:||:|.||:||||||||||.||||||..|||.||.|:.|:|.|
  Rat   328 KYKPESDELTAEKITQFCHHFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEEVAFDEKKNVFV 392

  Fly   391 EFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYF-RKEDNKVI 454
            ||||||||||||||||:|:|.|.|||:|:||||||||||||:|::|:.||||:|:| ...|..||
  Rat   393 EFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVI 457

  Fly   455 DFNLDRTLDDFVKFLDANGE--VADS------EPVEETEEEEEAPK--KDEL 496
            |:|.:||||.|.|||::.|:  ..|:      |.:|...||::..|  ||||
  Rat   458 DYNGERTLDGFKKFLESGGQDGAGDNDDLDLEEALEPDMEEDDDQKAVKDEL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	251/450 (56%)
		pdi_dom	33..133	CDD:273454	62/102 (61%)
		PDI_b_family	137..231	CDD:239279	42/93 (45%)
		PDI_b'_family	244..347	CDD:239280	49/102 (48%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	69/101 (68%)
P4hb	NP_037130.2	ER_PDI_fam	26..476	CDD:273457	251/449 (56%)
P4hb	NP_037130.2	Prevents secretion from ER	506..509		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350305
Domainoid	1	1.000	179	1.000	Domainoid score	I3444
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55495
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1171
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto96014
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770