DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and SPAC1F5.02

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_592871.1	Gene:	SPAC1F5.02 / 2541460	PomBaseID:	SPAC1F5.02	Length:	492	Species:	Schizosaccharomyces pombe

Alignment Length:	507	Identity:	184/507 - (36%)
Similarity:	295/507 - (58%)	Gaps:	48/507 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ICALFLAAS--YVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYA 67
            :.|.|||.|  :..||||.....:||:        .:||..::.::|:||||||||||||||||.
pombe     6 LLAAFLAFSGGFFCASAEVPKVNKEGL--------NELITADKVLMVKFYAPWCGHCKALAPEYE 62

  Fly    68 KAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV-EYSGGRQAADIIAWVTK 131
            .||.:| ||:. |.|.:||.|.||:|..:|::||||||..|::|..: :|||.|:...::.::.|
pombe    63 SAADEL-EKDG-ISLVEVDCTEEGDLCSEYSIRGYPTLNVFKNGKQISQYSGPRKHDALVKYMRK 125

  Fly   132 KTGPPAKDLTSVADAEQFL-KDNEIAIIGFFKDLESEEAKTFTKVANAL-DSFVFGVSSNADVIA 194
            :..|..|.: |....|.|: |.:::|::.||||.:..:  |:|:||..: |.|||..|.:.::..
pombe   126 QLLPTVKPI-SKDTLENFVEKADDLAVVAFFKDQKLND--TYTEVAEVMKDDFVFAASDDKELAK 187

  Fly   195 KYEAKDNGVVLF---KPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
            ...:...|:|.|   ...|..|.|:.|:.:..::..|..|.|:||:.:.|..:..|.....:...
pombe   188 SLGSNFPGIVAFTKDAAQDSDKLVYTGDWDPASIADFIGVSSIPLLDELNQMTFGKYQQSGLPLG 252

  Fly   257 LLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFG-----MNKE-EVPTI 315
            ::|:.|.|..  ::..|..:.:||||:|.:.|..:     |..|    :|     ||.| :.|..
pombe   253 IIFYNSTESR--DELYDVFQPLAKKYQDTLRFAFL-----DAVR----YGAVAKQMNVESDWPAF 306

  Fly   316 RLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESV 380
            .:..| :.|.||...:.:|:|:.:..|:..|:||||:..:.||.:||  .:..:.|||:.||:.:
pombe   307 VIANL-KSMLKYPFPTTELTAKAMTKFVGDFVDGKLQPKIKSQPIPE--SQEDLVVLVADNFDDI 368

  Fly   381 ALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKY 445
            .:|::|.||||||||||||||.|||.|::|||:|.|:.::|:||:|:|.|:: |:.||.||||.:
pombe   369 VMDETKDVLVEFYAPWCGHCKNLAPTYEKLAEEYSDDSNVVVAKIDATENDI-SVSISGFPTIMF 432

  Fly   446 FRKEDNKV--IDFNLDRTLDDFVKFLDANGEVADSEPVEETEEEEEAPKKDE 495
            |:..| ||  :.:..||||:|...|:|.:   |..||:::.:|...||..::
pombe   433 FKAND-KVNPVRYEGDRTLEDLSAFIDKH---ASFEPIKKEKESVPAPDLED 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	169/460 (37%)
		pdi_dom	33..133	CDD:273454	46/100 (46%)
		PDI_b_family	137..231	CDD:239279	27/98 (28%)
		PDI_b'_family	244..347	CDD:239280	25/108 (23%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	52/102 (51%)
SPAC1F5.02	NP_592871.1	ER_PDI_fam	23..464	CDD:273457	171/472 (36%)
		pdi_dom	27..126	CDD:273454	47/108 (44%)
		PDI_b_family	135..225	CDD:239279	25/91 (27%)
		PDI_b'_family	237..337	CDD:239280	26/111 (23%)
		PDI_a_PDI_a'_C	358..457	CDD:239293	52/100 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	118	1.000	Domainoid score	I1494
eggNOG	1	0.900	-	-		E2759_KOG0190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55495
Inparanoid	1	1.050	289	1.000	Inparanoid score	I641
OMA	1	1.010	-	-		QHG53639
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto100718
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2224
SonicParanoid	1	1.000	-	-		X241
TreeFam	0	0.000	Not matched by this tool.
	11	10.800