DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and ERP44

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_055866.1	Gene:	ERP44 / 23071	HGNCID:	18311	Length:	406	Species:	Homo sapiens

Alignment Length:	389	Identity:	92/389 - (23%)
Similarity:	165/389 - (42%)	Gaps:	76/389 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAK 68
            |.|:|.|..::|......|:...:      .:|..:::.:.:..||.|||.||...:.|.|.:.:
Human    12 LRCSLLLLVTWVFTPVTTEITSLD------TENIDEILNNADVALVNFYADWCRFSQMLHPIFEE 70

  Fly    69 AAQQLAEK---ESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPV--EYSGGRQAADIIAW 128
            |:..:.|:   |:.:..|:||.....::|::|.:..|||||.||:|..:  ||.|.|....:..:
Human    71 ASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADY 135

  Fly   129 VTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVI 193
            :.::...|.:::..:|:... |..::..|||:|:..:|:..:.|.:|||.|......:|:..||
Human   136 IRQQKSDPIQEIRDLAEITT-LDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDV- 198

  Fly   194 AKYEAKDNGVVLFKP----------------FD-------DKKSVFEGELNEENLKKFAQVQSLP 235
            :|.|......:::||                ||       ||......|:..||.::..: :.||
Human   199 SKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTE-EGLP 262

  Fly   236 LIVDFNHE---SASKIFGGSIKSHLLFFVSREG------GHIEKYVDPLKEIAKKYRDDILFVTI 291
            .::.|:.:   .:.:||...:...|   :|.:|      ...:|:..||..|.|...|   ...|
Human   263 FLILFHMKEDTESLEIFQNEVARQL---ISEKGTINFLHADCDKFRHPLLHIQKTPAD---CPVI 321

  Fly   292 SSDEEDHTRIFEFF------GMNKEEVPTIRLIKLE------------------EDMAKYKPES 331
            :.|...|..:|..|      |..|:.|..:...||.                  :|:|...|||
Human   322 AIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPES 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	86/366 (23%)
		pdi_dom	33..133	CDD:273454	30/104 (29%)
		PDI_b_family	137..231	CDD:239279	26/116 (22%)
		PDI_b'_family	244..347	CDD:239280	26/118 (22%)
		PDI_a_PDI_a'_C	368..469	CDD:239293
ERP44	NP_055866.1	PDI_a_ERp44	29..136	CDD:239294	31/112 (28%)
		PDI_b_ERp44	144..234	CDD:239368	21/91 (23%)
		Interaction with ITPR1. /evidence=ECO:0000250	236..285		10/49 (20%)
		PDI_b'_ERp44	245..355	CDD:239370	25/116 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..387		5/26 (19%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	403..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910