DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and Txndc2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001139474.1	Gene:	Txndc2 / 213272	MGIID:	2389312	Length:	550	Species:	Mus musculus

Alignment Length:	349	Identity:	82/349 - (23%)
Similarity:	131/349 - (37%)	Gaps:	109/349 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 KKTGPPAKDLTSVADAE----QFLKDNEIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNAD 191
            ||...|.....||...|    :.|||:          ::|:|    |||.          .|..|
Mouse   294 KKEDRPKSSEDSVQSKEGEVHKPLKDS----------IQSKE----TKVP----------KSPQD 334

  Fly   192 VIAKYEAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSH 256
            .|...|.|.:     :|..|.   .:.:.:||.......:||       ..:...|....||.
Mouse   335 SIQSKEDKTH-----RPLKDS---VQSKESEEPKSSHESIQS-------KEDKIHKPLKDSIP-- 382

  Fly   257 LLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLE 321
                 |:||           :|.|...|     ||.|.||  ....|...:..:|..||:  ..|
Mouse   383 -----SKEG-----------DIPKSPED-----TIQSQEE--ITASEEDTIQSQEGNTIK--SSE 422

  Fly   322 EDMAKYKPESDDLSA--ETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDK 384
            ||:...:.:...|.|  ||:|..|.:.:..|                        ..||.|..|.
Mouse   423 EDVQLSESKLLGLGAEIETLEEGLVRVIKDK------------------------EEFEEVLKDA 463

  Fly   385 -SKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANE--LESIKISSFPTIKYF 446
             .|.|.|:|.|.|||.|:.:.|::..|:.|:   ||::..::|:...|  ::..:|...||.:::
Mouse   464 GEKLVAVDFSAAWCGPCRMMKPLFHSLSLKH---EDVIFLEVDTEDCEQLVQDCEIFHLPTFQFY 525

  Fly   447 RKEDNKVIDFN------LDRTLDD 464
            :.|: ||.:|:      |:|::.:
Mouse   526 KNEE-KVGEFSGALVGKLERSISE 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	82/349 (23%)
		pdi_dom	33..133	CDD:273454	1/1 (100%)
		PDI_b_family	137..231	CDD:239279	20/97 (21%)
		PDI_b'_family	244..347	CDD:239280	27/104 (26%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	29/106 (27%)
Txndc2	NP_001139474.1	TRX_family	454..546	CDD:239245	29/95 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910