DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdi and PDILT

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_777584.1	Gene:	PDILT / 204474	HGNCID:	27338	Length:	584	Species:	Homo sapiens

Alignment Length:	525	Identity:	151/525 - (28%)
Similarity:	267/525 - (50%)	Gaps:	35/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKFLICALFLAASYVAA---SAEAEVKV-------------EEGVLVATVDNFKQLIADNEFVLV 49
            |..|...|.|.|:.|:|   |.|....|             |..:||.|.....|::....|::|
Human     1 MDLLWMPLLLVAACVSAVHSSPEVNAGVSSIHITKPVHILEERSLLVLTPAGLTQMLNQTRFLMV 65

  Fly    50 EFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGS-- 112
            .|:.|.....:.||.|..||.:.:.:.::.|...|||.|:|.||.:::.:...|.||.|..|:
Human    66 LFHNPSSKQSRNLAEELGKAVEIMGKGKNGIGFGKVDITIEKELQQEFGITKAPELKLFFEGNRS 130

  Fly   113 -PVEYSGGRQAADIIAWVTKKTGPPAKDLTSVADAEQFLKDNEIAIIGFFKDLESEEAKTFTKVA 176
             |:...|..::|.::.|:.::....|....|.....:|:....:.|:|||:|||.|.|:.|..|.
Human   131 EPISCKGVVESAALVVWLRRQISQKAFLFNSSEQVAEFVISRPLVIVGFFQDLEEEVAELFYDVI 195

  Fly   177 NALDSFVFGVSSNADVIAKYEAKDNGVVLFK--PFDDKKSVFEGELNEENLKKFAQVQSLPLIVD 239
            .......|||.:..:||.::....:.|::||  ...:::.:.....|::.|.:..:......:::
Human   196 KDFPELTFGVITIGNVIGRFHVTLDSVLVFKKGKIVNRQKLINDSTNKQELNRVIKQHLTDFVIE 260

  Fly   240 FNHESASKIFGGSIKSHLLFFVSREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEF 304
            :|.|:...|....|.||:|.|||:........:...|..:|::::.|||:.:.:||..:.|:|::
Human   261 YNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNGRVFKY 325

  Fly   305 FGMNKEEVPTIRLIKLEEDMAKYKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPV 369
            |.:.:.::|:::::.|..| |:||..|||::.|:::.|.:.||.....:|..|:|:|:.||:..|
Human   326 FRVTEVDIPSVQILNLSSD-ARYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWDQGLV 389

  Fly   370 KVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELES 434
            |.||..||..|..||.|.|.|.|||||...||.|.|:.::|..||:::..|:|||:|.|||:::.
Human   390 KQLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTANDIQL 454

  Fly   435 IKISSFPTIKYFRKEDNKVIDFNLDRTLDDFVKFLDANGE-----------VADSEPVEE--TEE 486
            :.:..:|..:.|.....:.:.:..:.||..|..||:::.:           |..:|.:||  ..|
Human   455 MYLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVEQNEVIEEEVLAE 519

  Fly   487 EEEAP 491
            |:|.|
Human   520 EKEVP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	132/451 (29%)
		pdi_dom	33..133	CDD:273454	28/102 (27%)
		PDI_b_family	137..231	CDD:239279	24/95 (25%)
		PDI_b'_family	244..347	CDD:239280	29/102 (28%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	37/100 (37%)
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	132/455 (29%)
PDILT	NP_777584.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	581..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156384
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.910