DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdi and pdi-2

DIOPT Version :9

Sequence 1:	NP_001287070.1	Gene:	Pdi / 39651	FlyBaseID:	FBgn0286818	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_508778.1	Gene:	pdi-2 / 180724	WormBaseID:	WBGene00003963	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	263/496 - (53%)
Similarity:	351/496 - (70%)	Gaps:	6/496 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYA 67
            |.:..||.   .|..::.|.::.||.|:|.|.|||.::|..|||:|||||||||||||:||||||
Worm     2 FRLVGLFF---LVLGASAAVIEEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEYA 63

  Fly    68 KAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSGSPVEYSGGRQAADIIAWVTKK 132
            |||.||.|:.|.|||.|:||||.||::.::.||||||||.||:|.|.||:|||....||||:.||
Worm    64 KAATQLKEEGSDIKLGKLDATVHGEVSSKFEVRGYPTLKLFRNGKPQEYNGGRDHDSIIAWLKKK 128

  Fly   133 TGPPAKDLTSVADAEQFLKDN-EIAIIGFFKDLESEEAKTFTKVANALDSFVFGVSSNADVIAKY 196
            |||.||.|.. |||.:.|::: ::.:||:|||..|::||||.:||..:|...||:|:...|.::.
Worm   129 TGPVAKPLAD-ADAVKELQESADVVVIGYFKDTTSDDAKTFLEVAAGIDDVPFGISTEDAVKSEI 192

  Fly   197 EAKDNGVVLFKPFDDKKSVFEGELNEENLKKFAQVQSLPLIVDFNHESASKIFGGSIKSHLLFFV 261
            |.|..|:||||.|||.:..|:.:|.::.||.:.|...|.|:.:|..|:||.||||.||||.|.||
Worm   193 ELKGEGIVLFKKFDDGRVAFDEKLTQDGLKTWIQANRLALVSEFTQETASVIFGGEIKSHNLLFV 257

  Fly   262 SREGGHIEKYVDPLKEIAKKYRDDILFVTISSDEEDHTRIFEFFGMNKEEVPTIRLIKLEEDMAK 326
            |:|.....|.....|..||:::..:|||.|::|.|::.||.||||:.|:|:|.||||.|||||.|
Worm   258 SKESSEFAKLEQEFKNAAKQFKGKVLFVYINTDVEENARIMEFFGLKKDELPAIRLISLEEDMTK 322

  Fly   327 YKPESDDLSAETIEAFLKKFLDGKLKQHLLSQELPEDWDKNPVKVLVSSNFESVALDKSKSVLVE 391
            :||:.::::.|.|..|.:.:|||.:|.||:|:::||||||||||:||..|||.||.|.:|:||||
Worm   323 FKPDFEEITTENISKFTQNYLDGSVKPHLMSEDIPEDWDKNPVKILVGKNFEQVARDNTKNVLVE 387

  Fly   392 FYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDNKVIDF 456
            ||||||||||||||.:|:|.||:.|:|.|||||||||.||:|.:||.||||||:|....|||:|:
Worm   388 FYAPWCGHCKQLAPTWDKLGEKFADDESIVIAKMDSTLNEVEDVKIQSFPTIKFFPAGSNKVVDY 452

  Fly   457 NLDRTLDDFVKFLDANG-EVADSEPVEETEEEEEAPKKDEL 496
            ..|||::.|.|||:.|| |.|.:...|:.|||.:.....||
Worm   453 TGDRTIEGFTKFLETNGKEGAGASEEEKAEEEADEEGHTEL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdi	NP_001287070.1	ER_PDI_fam	27..474	CDD:273457	249/448 (56%)
		pdi_dom	33..133	CDD:273454	66/99 (67%)
		PDI_b_family	137..231	CDD:239279	38/94 (40%)
		PDI_b'_family	244..347	CDD:239280	49/102 (48%)
		PDI_a_PDI_a'_C	368..469	CDD:239293	66/100 (66%)
pdi-2	NP_508778.1	ER_PDI_fam	23..471	CDD:273457	249/448 (56%)
		pdi_dom	28..129	CDD:273454	66/100 (66%)
		PDI_b_family	133..228	CDD:239279	39/95 (41%)
		PDI_b'_family	240..343	CDD:239280	49/102 (48%)
		PDI_a_PDI_a'_C	364..465	CDD:239293	66/100 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166728
Domainoid	1	1.000	170	1.000	Domainoid score	I2279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55495
Inparanoid	1	1.050	531	1.000	Inparanoid score	I660
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53639
OrthoDB	1	1.010	-	-		D222522at33208
OrthoFinder	1	1.000	-	-		FOG0000292
OrthoInspector	1	1.000	-	-		oto17226
orthoMCL	1	0.900	-	-		OOG6_100478
Panther	1	1.100	-	-	LDO	PTHR18929
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X241
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910